{"id":14,"date":"2023-09-04T20:50:05","date_gmt":"2023-09-04T20:50:05","guid":{"rendered":"https:\/\/www.merckconnect.com\/bridion\/?page_id=14"},"modified":"2025-07-29T09:48:40","modified_gmt":"2025-07-29T09:48:40","slug":"dosing-administration","status":"publish","type":"page","link":"https:\/\/www.merckconnect.com\/bridion\/dosing-administration\/","title":{"rendered":"Dosing for BRIDION\u00ae (sugammadex) | Official Site"},"content":{"rendered":"\n\n
Dosing for BRIDION\u00ae (sugammadex)<\/strong><\/h1><\/div>\n\n\n\n
Dosing based on actual body weight and depth of block<\/strong><\/h2><\/div>\n\n\n\n
Routine co-administration of an anticholinergic agent is not required.<\/h3><\/div>\n\n\n\n
Treatment with anticholinergic agents, such as atropine, should be administered if clinically significant bradycardia is observed.<\/p>\n\n\n\n\n
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The recommended dose of BRIDION does not depend on the anesthetic regimen.<\/li>
Administer BRIDION intravenously as a single bolus injection. The bolus injection may be given over 10 seconds into an existing intravenous line. BRIDION has only been administered as a single bolus injection in clinical trials.<\/li>
BRIDION 100 mg\/mL may be diluted to a concentration of 10 mg\/mL, using 0.9% sodium chloride injection, USP, to increase the accuracy of dosing in the pediatric population. Review the PI for additional instructions on how to dilute BRIDION for pediatric use.<\/li><\/ul><\/div>\n\n\n\n
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No dose adjustments of BRIDION required in these special patient populations<\/strong><\/h2><\/div>\n\n\n\n
Geriatric patients with normal organ function<\/li>
Patients diagnosed with or who have a history of pulmonary complications<\/li>
Patients diagnosed with or who have a history of cardiac disease (eg, patients with ischemic heart disease, chronic heart failure, or arrhythmia)<\/li>
Patients with mild to moderate renal impairment
BRIDION is not recommended for use in patients with severe renal impairment, including those requiring dialysis.<\/li><\/ul><\/li>
Obese patients with a BMI \u226540kg\/m2<\/sup><\/li><\/ul><\/div>\n\n\n\n
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Drug compatibility<\/strong><\/h2><\/div>\n\n\n\n
May inject BRIDION into the intravenous line of a running infusion with the following intravenous solutions:
0.9% sodium chloride<\/li>
5% dextrose<\/li>
0.45% sodium chloride and 2.5% dextrose<\/li>
Ringer\u2019s solution<\/li>
Isolyte P with 5% dextrose<\/li>
Ringer\u2019s lactate solution<\/li>
5% dextrose in 0.9% sodium chloride<\/li><\/ul><\/li>
Ensure the infusion line is adequately flushed (eg, with 0.9% sodium chloride) between administration of BRIDION and other drugs.<\/li>
Do not mix BRIDION with other products except those listed above.<\/li>
BRIDION is physically incompatible with verapamil, ondansetron, and ranitidine.<\/li>
Visually inspect parenteral drug products for particulate matter and discoloration prior to administration, whenever the solution and container permit.<\/li><\/ul><\/div>\n\n\n\n
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Abbreviations<\/strong><\/h2><\/div>\n\n\n\n
BMI = body mass index<\/li>
PTC = post-tetanic count<\/li>
TOF = train-of-four<\/li>
T2<\/sub> = second twitch<\/li><\/ul><\/div>\n\n\n\n
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