{"id":26,"date":"2023-09-04T20:53:50","date_gmt":"2023-09-04T20:53:50","guid":{"rendered":"https:\/\/www.merckconnect.com\/bridion\/?page_id=26"},"modified":"2025-07-29T11:31:29","modified_gmt":"2025-07-29T11:31:29","slug":"mechanism-of-action","status":"publish","type":"page","link":"https:\/\/www.merckconnect.com\/bridion\/mechanism-of-action\/","title":{"rendered":"Mechanism of Action (MoA) for BRIDION\u00ae (sugammadex)"},"content":{"rendered":"<link rel='stylesheet' id='vivid360-heading-css-css' href='https:\/\/www.merckconnect.com\/bridion\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/heading\/css\/style.min.css?ver=1764613072' media='all' \/>\n\n<div class=\"vivid360-heading default-hcp-fontsize default-hcp-tablet-fontsize default-hcp-mobile-fontsize\" id=\"a1bc841a1-b5b0-46bb-86f7-3c9438a7c345\"><h1 class=\"content-width fontWeightRegular\" style=\"--desktopFontSize:var(--h1FontSizeDesktop);--tabletFontSize:var(--h1FontSizeDesktop);--mobileFontSize:var(--h1FontSizeMobile);--desktopLineHeightSize:var(--h1LineHeightDesktop);--tabletLineHeightSize:var(--h1LineHeightDesktop);--mobileLineHeightSize:\" id=\"top\"><strong>Mechanism of Action (MoA) for BRIDION\u00ae (sugammadex)<\/strong><\/h1><\/div>\n\n\n\n<div class=\"vivid360-heading default-hcp-fontsize default-hcp-tablet-fontsize default-hcp-mobile-fontsize\" id=\"ac4e98ba8-1ab1-4e04-9b1b-52e11cf86533\"><h2 class=\"content-width fontWeightRegular\" style=\"--desktopFontSize:var(--h2FontSizeDesktop);--tabletFontSize:var(--h2FontSizeDesktop);--mobileFontSize:var(--h2FontSizeMobile);--desktopLineHeightSize:var(--h2LineHeightDesktop);--tabletLineHeightSize:var(--h2LineHeightDesktop);--mobileLineHeightSize:\" id=\"\"><strong>BRIDION works differently than neostigmine by directly encapsulating, binding, and thus inactivating rocuronium or vecuronium.<sup>1-3<\/sup><\/strong><\/h2><\/div>\n\n\n<style>.vivid360-content-switcher-titles button.has-primary-border { border : 2px solid #333333 !important; color: #333333; border-right: none !important; outline: none !important; text-transform: uppercase; }.vivid360-content-switcher-titles button.has-primary-border.open { background: #333333 !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-primary-border.open:hover { background: #333333 !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-primary-border:not(open) { color: #333333 !important; }.vivid360-content-switcher-titles button.has-primary-border:not(open):hover { background: #333333 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(0,0,0,0.2); border: none !important; padding: 0 22px; }.vivid360-content-switcher-titles button.has-primary-border:not(open):active { background: #333333 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-primary-border:not(open):focus { background: #333333 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-primary-border::selection {display: none; }.vivid360-content-switcher-titles button.has-primary-border:last-of-type { border-right: 2px solid #333333 !important; }.vivid360-content-switcher-titles button.has-primary dark-border { border : 2px solid #333333 !important; color: #333333; border-right: none !important; outline: none !important; text-transform: uppercase; }.vivid360-content-switcher-titles button.has-primary dark-border.open { background: #333333 !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-primary dark-border.open:hover { background: #333333 !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-primary dark-border:not(open) { color: #333333 !important; }.vivid360-content-switcher-titles button.has-primary dark-border:not(open):hover { background: #333333 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(0,0,0,0.2); border: none !important; padding: 0 22px; }.vivid360-content-switcher-titles button.has-primary dark-border:not(open):active { background: #333333 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-primary dark-border:not(open):focus { background: #333333 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-primary dark-border::selection {display: none; }.vivid360-content-switcher-titles button.has-primary dark-border:last-of-type { border-right: 2px solid #333333 !important; }.vivid360-content-switcher-titles button.has-primary light-border { border : 2px solid #f7941c !important; color: #f7941c; border-right: none !important; outline: none !important; text-transform: uppercase; }.vivid360-content-switcher-titles button.has-primary light-border.open { background: #f7941c !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-primary light-border.open:hover { background: #f7941c !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-primary light-border:not(open) { color: #f7941c !important; }.vivid360-content-switcher-titles button.has-primary light-border:not(open):hover { background: #f7941c !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(0,0,0,0.2); border: none !important; padding: 0 22px; }.vivid360-content-switcher-titles button.has-primary light-border:not(open):active { background: #f7941c !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-primary light-border:not(open):focus { background: #f7941c !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-primary light-border::selection {display: none; }.vivid360-content-switcher-titles button.has-primary light-border:last-of-type { border-right: 2px solid #f7941c !important; }.vivid360-content-switcher-titles button.has-primary alternate color-border { border : 2px solid #5450E4 !important; color: #5450E4; border-right: none !important; outline: none !important; text-transform: uppercase; }.vivid360-content-switcher-titles button.has-primary alternate color-border.open { background: #5450E4 !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-primary alternate color-border.open:hover { background: #5450E4 !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-primary alternate color-border:not(open) { color: #5450E4 !important; }.vivid360-content-switcher-titles button.has-primary alternate color-border:not(open):hover { background: #5450E4 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(0,0,0,0.2); border: none !important; padding: 0 22px; }.vivid360-content-switcher-titles button.has-primary alternate color-border:not(open):active { background: #5450E4 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-primary alternate color-border:not(open):focus { background: #5450E4 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-primary alternate color-border::selection {display: none; }.vivid360-content-switcher-titles button.has-primary alternate color-border:last-of-type { border-right: 2px solid #5450E4 !important; }.vivid360-content-switcher-titles button.has-primary alternate color dark-border { border : 2px solid #3A379F !important; color: #3A379F; border-right: none !important; outline: none !important; text-transform: uppercase; }.vivid360-content-switcher-titles button.has-primary alternate color dark-border.open { background: #3A379F !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-primary alternate color dark-border.open:hover { background: #3A379F !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-primary alternate color dark-border:not(open) { color: #3A379F !important; }.vivid360-content-switcher-titles button.has-primary alternate color dark-border:not(open):hover { background: #3A379F !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(0,0,0,0.2); border: none !important; padding: 0 22px; }.vivid360-content-switcher-titles button.has-primary alternate color dark-border:not(open):active { background: #3A379F !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-primary alternate color dark-border:not(open):focus { background: #3A379F !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-primary alternate color dark-border::selection {display: none; }.vivid360-content-switcher-titles button.has-primary alternate color dark-border:last-of-type { border-right: 2px solid #3A379F !important; }.vivid360-content-switcher-titles button.has-primary alternate color light-border { border : 2px solid #C3C1F5 !important; color: #C3C1F5; border-right: none !important; outline: none !important; text-transform: uppercase; }.vivid360-content-switcher-titles button.has-primary alternate color light-border.open { background: #C3C1F5 !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-primary alternate color light-border.open:hover { background: #C3C1F5 !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-primary alternate color light-border:not(open) { color: #C3C1F5 !important; }.vivid360-content-switcher-titles button.has-primary alternate color light-border:not(open):hover { background: #C3C1F5 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(0,0,0,0.2); border: none !important; padding: 0 22px; }.vivid360-content-switcher-titles button.has-primary alternate color light-border:not(open):active { background: #C3C1F5 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-primary alternate color light-border:not(open):focus { background: #C3C1F5 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-primary alternate color light-border::selection {display: none; }.vivid360-content-switcher-titles button.has-primary alternate color light-border:last-of-type { border-right: 2px solid #C3C1F5 !important; }.vivid360-content-switcher-titles button.has-secondary 1-border { border : 2px solid #2b2b2b !important; color: #2b2b2b; border-right: none !important; outline: none !important; text-transform: uppercase; }.vivid360-content-switcher-titles button.has-secondary 1-border.open { background: #2b2b2b !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-secondary 1-border.open:hover { background: #2b2b2b !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-secondary 1-border:not(open) { color: #2b2b2b !important; }.vivid360-content-switcher-titles button.has-secondary 1-border:not(open):hover { background: #2b2b2b !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(0,0,0,0.2); border: none !important; padding: 0 22px; }.vivid360-content-switcher-titles button.has-secondary 1-border:not(open):active { background: #2b2b2b !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-secondary 1-border:not(open):focus { background: #2b2b2b !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-secondary 1-border::selection {display: none; }.vivid360-content-switcher-titles button.has-secondary 1-border:last-of-type { border-right: 2px solid #2b2b2b !important; }.vivid360-content-switcher-titles button.has-secondary 2-border { border : 2px solid #6eceb2 !important; color: #6eceb2; border-right: none !important; outline: none !important; text-transform: uppercase; }.vivid360-content-switcher-titles button.has-secondary 2-border.open { background: #6eceb2 !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-secondary 2-border.open:hover { background: #6eceb2 !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-secondary 2-border:not(open) { color: #6eceb2 !important; }.vivid360-content-switcher-titles button.has-secondary 2-border:not(open):hover { background: #6eceb2 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(0,0,0,0.2); border: none !important; padding: 0 22px; }.vivid360-content-switcher-titles button.has-secondary 2-border:not(open):active { background: #6eceb2 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-secondary 2-border:not(open):focus { background: #6eceb2 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-secondary 2-border::selection {display: none; }.vivid360-content-switcher-titles button.has-secondary 2-border:last-of-type { border-right: 2px solid #6eceb2 !important; }.vivid360-content-switcher-titles button.has-secondary 3-border { border : 2px solid #f7f7f7 !important; color: #f7f7f7; border-right: none !important; outline: none !important; text-transform: uppercase; }.vivid360-content-switcher-titles button.has-secondary 3-border.open { background: #f7f7f7 !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-secondary 3-border.open:hover { background: #f7f7f7 !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-secondary 3-border:not(open) { color: #f7f7f7 !important; }.vivid360-content-switcher-titles button.has-secondary 3-border:not(open):hover { background: #f7f7f7 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(0,0,0,0.2); border: none !important; padding: 0 22px; }.vivid360-content-switcher-titles button.has-secondary 3-border:not(open):active { background: #f7f7f7 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-secondary 3-border:not(open):focus { background: #f7f7f7 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-secondary 3-border::selection {display: none; }.vivid360-content-switcher-titles button.has-secondary 3-border:last-of-type { border-right: 2px solid #f7f7f7 !important; }.vivid360-content-switcher-titles button.has-black-border { border : 2px solid #000 !important; color: #000; border-right: none !important; outline: none !important; text-transform: uppercase; }.vivid360-content-switcher-titles button.has-black-border.open { background: #000 !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-black-border.open:hover { background: #000 !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-black-border:not(open) { color: #000 !important; }.vivid360-content-switcher-titles button.has-black-border:not(open):hover { background: #000 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(0,0,0,0.2); border: none !important; padding: 0 22px; }.vivid360-content-switcher-titles button.has-black-border:not(open):active { background: #000 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-black-border:not(open):focus { background: #000 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-black-border::selection {display: none; }.vivid360-content-switcher-titles button.has-black-border:last-of-type { border-right: 2px solid #000 !important; }.vivid360-content-switcher-titles button.has-dark gray-border { border : 2px solid #555 !important; color: #555; border-right: none !important; outline: none !important; text-transform: uppercase; }.vivid360-content-switcher-titles button.has-dark gray-border.open { background: #555 !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-dark gray-border.open:hover { background: #555 !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-dark gray-border:not(open) { color: #555 !important; }.vivid360-content-switcher-titles button.has-dark gray-border:not(open):hover { background: #555 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(0,0,0,0.2); border: none !important; padding: 0 22px; }.vivid360-content-switcher-titles button.has-dark gray-border:not(open):active { background: #555 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-dark gray-border:not(open):focus { background: #555 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-dark gray-border::selection {display: none; }.vivid360-content-switcher-titles button.has-dark gray-border:last-of-type { border-right: 2px solid #555 !important; }.vivid360-content-switcher-titles button.has-medium gray-border { border : 2px solid #a4a4a4 !important; color: #a4a4a4; border-right: none !important; outline: none !important; text-transform: uppercase; }.vivid360-content-switcher-titles button.has-medium gray-border.open { background: #a4a4a4 !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-medium gray-border.open:hover { background: #a4a4a4 !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-medium gray-border:not(open) { color: #a4a4a4 !important; }.vivid360-content-switcher-titles button.has-medium gray-border:not(open):hover { background: #a4a4a4 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(0,0,0,0.2); border: none !important; padding: 0 22px; }.vivid360-content-switcher-titles button.has-medium gray-border:not(open):active { background: #a4a4a4 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-medium gray-border:not(open):focus { background: #a4a4a4 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-medium gray-border::selection {display: none; }.vivid360-content-switcher-titles button.has-medium gray-border:last-of-type { border-right: 2px solid #a4a4a4 !important; }.vivid360-content-switcher-titles button.has-light gray-border { border : 2px solid #e4e4e4 !important; color: #e4e4e4; border-right: none !important; outline: none !important; text-transform: uppercase; }.vivid360-content-switcher-titles button.has-light gray-border.open { background: #e4e4e4 !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-light gray-border.open:hover { background: #e4e4e4 !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-light gray-border:not(open) { color: #e4e4e4 !important; }.vivid360-content-switcher-titles button.has-light gray-border:not(open):hover { background: #e4e4e4 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(0,0,0,0.2); border: none !important; padding: 0 22px; }.vivid360-content-switcher-titles button.has-light gray-border:not(open):active { background: #e4e4e4 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-light gray-border:not(open):focus { background: #e4e4e4 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-light gray-border::selection {display: none; }.vivid360-content-switcher-titles button.has-light gray-border:last-of-type { border-right: 2px solid #e4e4e4 !important; }.vivid360-content-switcher-titles button.has-ultralight gray-border { border : 2px solid #f4f4f4 !important; color: #f4f4f4; border-right: none !important; outline: none !important; text-transform: uppercase; }.vivid360-content-switcher-titles button.has-ultralight gray-border.open { background: #f4f4f4 !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-ultralight gray-border.open:hover { background: #f4f4f4 !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-ultralight gray-border:not(open) { color: #f4f4f4 !important; }.vivid360-content-switcher-titles button.has-ultralight gray-border:not(open):hover { background: #f4f4f4 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(0,0,0,0.2); border: none !important; padding: 0 22px; }.vivid360-content-switcher-titles button.has-ultralight gray-border:not(open):active { background: #f4f4f4 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-ultralight gray-border:not(open):focus { background: #f4f4f4 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-ultralight gray-border::selection {display: none; }.vivid360-content-switcher-titles button.has-ultralight gray-border:last-of-type { border-right: 2px solid #f4f4f4 !important; }.vivid360-content-switcher-titles button.has-white-border { border : 2px solid #FFF !important; color: #FFF; border-right: none !important; outline: none !important; text-transform: uppercase; }.vivid360-content-switcher-titles button.has-white-border.open { background: #FFF !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-white-border.open:hover { background: #FFF !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-white-border:not(open) { color: #FFF !important; }.vivid360-content-switcher-titles button.has-white-border:not(open):hover { background: #FFF !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(0,0,0,0.2); border: none !important; padding: 0 22px; }.vivid360-content-switcher-titles button.has-white-border:not(open):active { background: #FFF !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-white-border:not(open):focus { background: #FFF !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-white-border::selection {display: none; }.vivid360-content-switcher-titles button.has-white-border:last-of-type { border-right: 2px solid #FFF !important; }.vivid360-content-switcher-titles button.has-dark text-border { border : 2px solid #333 !important; color: #333; border-right: none !important; outline: none !important; text-transform: uppercase; }.vivid360-content-switcher-titles button.has-dark text-border.open { background: #333 !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-dark text-border.open:hover { background: #333 !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-dark text-border:not(open) { color: #333 !important; }.vivid360-content-switcher-titles button.has-dark text-border:not(open):hover { background: #333 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(0,0,0,0.2); border: none !important; padding: 0 22px; }.vivid360-content-switcher-titles button.has-dark text-border:not(open):active { background: #333 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-dark text-border:not(open):focus { background: #333 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-dark text-border::selection {display: none; }.vivid360-content-switcher-titles button.has-dark text-border:last-of-type { border-right: 2px solid #333 !important; }.vivid360-content-switcher-titles button.has-light text-border { border : 2px solid #757575 !important; color: #757575; border-right: none !important; outline: none !important; text-transform: uppercase; }.vivid360-content-switcher-titles button.has-light text-border.open { background: #757575 !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-light text-border.open:hover { background: #757575 !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-light text-border:not(open) { color: #757575 !important; }.vivid360-content-switcher-titles button.has-light text-border:not(open):hover { background: #757575 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(0,0,0,0.2); border: none !important; padding: 0 22px; }.vivid360-content-switcher-titles button.has-light text-border:not(open):active { background: #757575 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-light text-border:not(open):focus { background: #757575 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-light text-border::selection {display: none; }.vivid360-content-switcher-titles button.has-light text-border:last-of-type { border-right: 2px solid #757575 !important; }.vivid360-content-switcher-titles button.has-success system-border { border : 2px solid #008a00 !important; color: #008a00; border-right: none !important; outline: none !important; text-transform: uppercase; }.vivid360-content-switcher-titles button.has-success system-border.open { background: #008a00 !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-success system-border.open:hover { background: #008a00 !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-success system-border:not(open) { color: #008a00 !important; }.vivid360-content-switcher-titles button.has-success system-border:not(open):hover { background: #008a00 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(0,0,0,0.2); border: none !important; padding: 0 22px; }.vivid360-content-switcher-titles button.has-success system-border:not(open):active { background: #008a00 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-success system-border:not(open):focus { background: #008a00 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-success system-border::selection {display: none; }.vivid360-content-switcher-titles button.has-success system-border:last-of-type { border-right: 2px solid #008a00 !important; }.vivid360-content-switcher-titles button.has-error system-border { border : 2px solid #db281a !important; color: #db281a; border-right: none !important; outline: none !important; text-transform: uppercase; }.vivid360-content-switcher-titles button.has-error system-border.open { background: #db281a !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-error system-border.open:hover { background: #db281a !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-error system-border:not(open) { color: #db281a !important; }.vivid360-content-switcher-titles button.has-error system-border:not(open):hover { background: #db281a !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(0,0,0,0.2); border: none !important; padding: 0 22px; }.vivid360-content-switcher-titles button.has-error system-border:not(open):active { background: #db281a !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-error system-border:not(open):focus { background: #db281a !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-error system-border::selection {display: none; }.vivid360-content-switcher-titles button.has-error system-border:last-of-type { border-right: 2px solid #db281a !important; }.vivid360-content-switcher-titles button.has-alert system-border { border : 2px solid #ffab00 !important; color: #ffab00; border-right: none !important; outline: none !important; text-transform: uppercase; }.vivid360-content-switcher-titles button.has-alert system-border.open { background: #ffab00 !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-alert system-border.open:hover { background: #ffab00 !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-alert system-border:not(open) { color: #ffab00 !important; }.vivid360-content-switcher-titles button.has-alert system-border:not(open):hover { background: #ffab00 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(0,0,0,0.2); border: none !important; padding: 0 22px; }.vivid360-content-switcher-titles button.has-alert system-border:not(open):active { background: #ffab00 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-alert system-border:not(open):focus { background: #ffab00 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-alert system-border::selection {display: none; }.vivid360-content-switcher-titles button.has-alert system-border:last-of-type { border-right: 2px solid #ffab00 !important; }.vivid360-content-switcher-titles button.has-neutral system-border { border : 2px solid #5450e4 !important; color: #5450e4; border-right: none !important; outline: none !important; text-transform: uppercase; }.vivid360-content-switcher-titles button.has-neutral system-border.open { background: #5450e4 !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-neutral system-border.open:hover { background: #5450e4 !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-neutral system-border:not(open) { color: #5450e4 !important; }.vivid360-content-switcher-titles button.has-neutral system-border:not(open):hover { background: #5450e4 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(0,0,0,0.2); border: none !important; padding: 0 22px; }.vivid360-content-switcher-titles button.has-neutral system-border:not(open):active { background: #5450e4 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-neutral system-border:not(open):focus { background: #5450e4 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-neutral system-border::selection {display: none; }.vivid360-content-switcher-titles button.has-neutral system-border:last-of-type { border-right: 2px solid #5450e4 !important; }.vivid360-content-switcher-titles button.has-success system (light background)-border { border : 2px solid #e5f4e5 !important; color: #e5f4e5; border-right: none !important; outline: none !important; text-transform: uppercase; }.vivid360-content-switcher-titles button.has-success system (light background)-border.open { background: #e5f4e5 !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-success system (light background)-border.open:hover { background: #e5f4e5 !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-success system (light background)-border:not(open) { color: #e5f4e5 !important; }.vivid360-content-switcher-titles button.has-success system (light background)-border:not(open):hover { background: #e5f4e5 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(0,0,0,0.2); border: none !important; padding: 0 22px; }.vivid360-content-switcher-titles button.has-success system (light background)-border:not(open):active { background: #e5f4e5 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-success system (light background)-border:not(open):focus { background: #e5f4e5 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-success system (light background)-border::selection {display: none; }.vivid360-content-switcher-titles button.has-success system (light background)-border:last-of-type { border-right: 2px solid #e5f4e5 !important; }.vivid360-content-switcher-titles button.has-error system (light background)-border { border : 2px solid #ffe7e6 !important; color: #ffe7e6; border-right: none !important; outline: none !important; text-transform: uppercase; }.vivid360-content-switcher-titles button.has-error system (light background)-border.open { background: #ffe7e6 !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-error system (light background)-border.open:hover { background: #ffe7e6 !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-error system (light background)-border:not(open) { color: #ffe7e6 !important; }.vivid360-content-switcher-titles button.has-error system (light background)-border:not(open):hover { background: #ffe7e6 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(0,0,0,0.2); border: none !important; padding: 0 22px; }.vivid360-content-switcher-titles button.has-error system (light background)-border:not(open):active { background: #ffe7e6 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-error system (light background)-border:not(open):focus { background: #ffe7e6 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-error system (light background)-border::selection {display: none; }.vivid360-content-switcher-titles button.has-error system (light background)-border:last-of-type { border-right: 2px solid #ffe7e6 !important; }.vivid360-content-switcher-titles button.has-alert system (light background)-border { border : 2px solid #fff5c6 !important; color: #fff5c6; border-right: none !important; outline: none !important; text-transform: uppercase; }.vivid360-content-switcher-titles button.has-alert system (light background)-border.open { background: #fff5c6 !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-alert system (light background)-border.open:hover { background: #fff5c6 !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-alert system (light background)-border:not(open) { color: #fff5c6 !important; }.vivid360-content-switcher-titles button.has-alert system (light background)-border:not(open):hover { background: #fff5c6 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(0,0,0,0.2); border: none !important; padding: 0 22px; }.vivid360-content-switcher-titles button.has-alert system (light background)-border:not(open):active { background: #fff5c6 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-alert system (light background)-border:not(open):focus { background: #fff5c6 !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-alert system (light background)-border::selection {display: none; }.vivid360-content-switcher-titles button.has-alert system (light background)-border:last-of-type { border-right: 2px solid #fff5c6 !important; }.vivid360-content-switcher-titles button.has-neutral system (light background)-border { border : 2px solid #ededfc !important; color: #ededfc; border-right: none !important; outline: none !important; text-transform: uppercase; }.vivid360-content-switcher-titles button.has-neutral system (light background)-border.open { background: #ededfc !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-neutral system (light background)-border.open:hover { background: #ededfc !important; color: #fff !important; }.vivid360-content-switcher-titles button.has-neutral system (light background)-border:not(open) { color: #ededfc !important; }.vivid360-content-switcher-titles button.has-neutral system (light background)-border:not(open):hover { background: #ededfc !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(0,0,0,0.2); border: none !important; padding: 0 22px; }.vivid360-content-switcher-titles button.has-neutral system (light background)-border:not(open):active { background: #ededfc !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-neutral system (light background)-border:not(open):focus { background: #ededfc !important; color: #ffffff !important; box-shadow: inset 0 0 99999px rgba(255,255,255,0.2); }.vivid360-content-switcher-titles button.has-neutral system (light background)-border::selection {display: none; }.vivid360-content-switcher-titles button.has-neutral system (light background)-border:last-of-type { border-right: 2px solid #ededfc !important; }<\/style><link rel='stylesheet' id='vivid360-content-switcher-css-css' href='https:\/\/www.merckconnect.com\/bridion\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/content-switcher\/css\/style.min.css?ver=1771502711' media='all' \/>\n\n<div class=\"wp-block-vivid360-content-switcher vivid360-content-switcher full-page-width\"><div class=\"vivid360-content-switcher-titles\" role=\"tablist\" aria-label=\"Content Switcher\" style=\"--activeTitleBgColor:var(--colorPrimary);--activeTitleTextColor:var(--colorWhite);--activeTitleBorderColor:var(--colorPrimary);--inactiveTitleBgColor:var(--colorWhite);--inactiveTitleTextColor:var(--colorPrimary);--inactiveTitleBorderColor:var(--colorPrimary);--inactiveHoverBgColor:var(--colorPrimary);--inactiveHoverTextColor:var(--colorPrimaryDark);justify-content:left\"><span class=\"vivid360-content-switcher-titles-left\"><\/span><button type=\"button\" role=\"tab\" aria-controls=\"tabpanel-1\" data-tab=\"1\" style=\"font-weight:;font-style:\" class=\"btn vivid360-content-switcher-title vivid360-content-switcher-title-1 open\" id=\"mechanism-of-action\" data-design-category=\"content_switcher\" data-event-name=\"content_switcher_click\" data-design-module=\"content_switcher\">See the mechanism of BRIDION in action<div class=\"empty-div\"><\/div><\/button><button type=\"button\" role=\"tab\" aria-controls=\"tabpanel-2\" data-tab=\"2\" style=\"font-weight:;font-style:\" class=\"btn vivid360-content-switcher-title vivid360-content-switcher-title-2\" id=\"encapsulation-in-action\" data-design-category=\"content_switcher\" data-event-name=\"content_switcher_click\" data-design-module=\"content_switcher\">See the BRIDION encapsulation in action<div class=\"empty-div\"><\/div><\/button><span class=\"vivid360-content-switcher-titles-right\"><\/span><\/div><div class=\"vivid360-content-switcher-contents\"><link rel='stylesheet' id='vivid360-switcher-content-css-css' href='https:\/\/www.merckconnect.com\/bridion\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/switcher-content\/css\/style.min.css?ver=1764613072' media='all' \/>\n\n<div class=\"vivid360-content-switcher-content vivid360-content-switcher-content-1 open\">\n<div class=\"wp-block-columns mb-0 is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\"><link rel='stylesheet' id='vivid360-video-module-css-css' href='https:\/\/www.merckconnect.com\/bridion\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/video-module\/css\/style.min.css?ver=1765898918' media='all' \/>\n\n<div id=\"\" class=\"wp-block-vivid360-video-module vivid360-block-video-module video-module-center full-page-width\"><div class=\"video-wrapper\"><div data-tracking-video=\"6218171056001\" class=\"vivid360-block-video-module-video-content\"><div><video id=\"video-block\" data-design-category=\"Video\" data-account=\"1905768940001\" data-player=\"default\" data-embed=\"default\" controls data-video-id=\"6218171056001\" data-playlist-id=\"\" data-application-id=\"\" class=\"vjs-fluid video-js\" aria-labelledby=\"video_label\" aria-describedby=\"video_description\"><\/video><\/div><\/div><div id=\"video_label\" hidden>BrightCove Video<\/div><div id=\"video_description\" aria-live=\"polite\" role=\"caption\" hidden><\/div><figure class=\"text-align-left\"><figcaption><\/figcaption><\/figure><\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"vivid360-content-switcher-content vivid360-content-switcher-content-2\">\n<div class=\"wp-block-columns mb-0 is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<div id=\"\" class=\"wp-block-vivid360-video-module vivid360-block-video-module video-module-center full-page-width\"><div class=\"video-wrapper\"><div data-tracking-video=\"6218170762001\" class=\"vivid360-block-video-module-video-content\"><div><video id=\"video-block\" data-design-category=\"Video\" data-account=\"1905768940001\" data-player=\"default\" data-embed=\"default\" controls data-video-id=\"6218170762001\" data-playlist-id=\"\" data-application-id=\"\" class=\"vjs-fluid video-js\" aria-labelledby=\"video_label\" aria-describedby=\"video_description\"><\/video><\/div><\/div><div id=\"video_label\" hidden>BrightCove Video<\/div><div id=\"video_description\" aria-live=\"polite\" role=\"caption\" hidden><\/div><figure class=\"text-align-left\"><figcaption><\/figcaption><\/figure><\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p>After intravenous injection, BRIDION distributes through the plasma and binds to the neuromuscular blocking agents rocuronium or vecuronium to form a complex.<sup>3<\/sup>&nbsp;BRIDION does not affect the release or breakdown of acetylcholine.<sup>2<\/sup><\/p>\n\n\n<link rel='stylesheet' id='vivid360-list-css-css' href='https:\/\/www.merckconnect.com\/bridion\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/list\/css\/style.min.css?ver=1764613072' media='all' \/>\n\n<div class=\"vivid-block-list content-width  default-list block-56835626-febb-441a-a54e-f09c3f36e7a1\" data-image=\"\" data-image-mobile=\"\" data-image-all=\"\" data-image-all-mobile=\"\" data-icon-color=\"#333\" data-text-color=\"#333\" data-client-id=\"block-56835626-febb-441a-a54e-f09c3f36e7a1\"><ul class=\"first-level\"><li>The reduction of free rocuronium available in the blood plasma creates a concentration gradient with the neuromuscular junction.<sup>2<\/sup><\/li><li>As a result, there is a shift of rocuronium into the plasma, where it is encapsulated by BRIDION.<sup>2<\/sup><\/li><li>This process reduces the amount of neuromuscular blocking agent available to bind to nicotinic cholinergic receptors in the neuromuscular junction, resulting in the reversal of neuromuscular blockade.<\/li><li>The process is similar for vecuronium.<\/li><li>The elimination half-life of BRIDION for adults with normal renal function is approximately 2 hours, with over 90% excreted within 24 hours, primarily in urine.<\/li><\/ul><\/div>\n\n\n<link rel='stylesheet' id='vivid360-spacer-css-css' href='https:\/\/www.merckconnect.com\/bridion\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/spacer\/css\/style.min.css?ver=1764613072' media='all' \/>\n\n<div style=\"background-color:transparent;height:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-16\"><\/div>\n\n\n\n<div class=\"vivid360-heading default-hcp-fontsize default-hcp-tablet-fontsize default-hcp-mobile-fontsize\" id=\"a30b5e5fa-b7a7-4e7f-9cbe-ffd47dddb280\"><h2 class=\"content-width fontWeightRegular\" style=\"--desktopFontSize:var(--h2FontSizeDesktop);--tabletFontSize:var(--h2FontSizeDesktop);--mobileFontSize:var(--h2FontSizeMobile);--desktopLineHeightSize:var(--h2LineHeightDesktop);--tabletLineHeightSize:var(--h2LineHeightDesktop);--mobileLineHeightSize:\" id=\"\"><strong>Abbreviations<\/strong><\/h2><\/div>\n\n\n\n<div class=\"vivid-block-list content-width  default-list block-25c5f67a-bd65-4750-a7ba-72cefb32d91a\" data-image=\"\" data-image-mobile=\"\" data-image-all=\"\" data-image-all-mobile=\"\" data-icon-color=\"#333\" data-text-color=\"#333\" data-client-id=\"block-25c5f67a-bd65-4750-a7ba-72cefb32d91a\"><ul class=\"first-level\"><li>NMB = neuromuscular blockade<\/li><li>NMBA = neuromuscular blocking agent<\/li><li>NMJ = neuromuscular junction<\/li><\/ul><\/div>\n\n\n\n<div style=\"background-color:transparent;height:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-16\"><\/div>\n\n\n\n<div class=\"vivid360-heading\" id=\"ab641d7d2-18ab-43d6-82b1-4ff60261e579\"><h3 class=\"content-width fontWeightRegular\" style=\"--desktopFontSize:18px;--tabletFontSize:var(--h3FontSizeDesktop);--mobileFontSize:var(--h3FontSizeMobile);--desktopLineHeightSize:27px;--tabletLineHeightSize:var(--h3LineHeightDesktop);--mobileLineHeightSize:\" id=\"\">References<\/h3><\/div>\n\n\n\n<div class=\"vivid-block-list content-width  block-3d3b64ff-ba6d-452b-a273-5446e3dc4a11\" data-image=\"\" data-image-mobile=\"\" data-image-all=\"\" data-image-all-mobile=\"\" data-icon-color=\"#333\" data-text-color=\"#333\" data-client-id=\"block-3d3b64ff-ba6d-452b-a273-5446e3dc4a11\"><ol class=\"first-level default-order\"><li>Renew JR, Fuchs-Buder T. Neuromuscular Monitoring. In: Gropper MA, ed. <em>Miller&#8217;s Anesthesia<\/em>. 10th ed. Elsevier; 2024:1209-1226.<\/li><li>Bom A, Hope F, Rutherford S, et al. Preclinical pharmacology of sugammadex.&nbsp;<em>J Crit Care<\/em>. 2009;24(1):29-35.<\/li><li>Gijsenbergh F, Ramael S, Houwing N, et al. First human exposure of Org 25969, a novel agent to reverse the action of rocuronium bromide.&nbsp;<em>Anesthesiology<\/em>. 2005;103(4):695-703.&nbsp;<\/li><li>Bom A, Bradley M, Cameron K, et al. A novel concept of reversing neuromuscular block: chemical encapsulation of rocuronium bromide by a cyclodextrin-based synthetic host.&nbsp;<em>Angew Chem Int Ed Engl.<\/em>&nbsp;2002;41(2):266-270.<\/li><\/ol><\/div>\n\n\n\n<div style=\"background-color:transparent;height:32px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-32\"><\/div>\n\n\n\n<p><a href=\"#top\" aria-label=\"#\">Back to top<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>After intravenous injection, BRIDION distributes through the plasma and binds to the neuromuscular blocking agents rocuronium or vecuronium to form a complex.3&nbsp;BRIDION&#8230;<\/p>\n","protected":false},"author":444,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_trash_the_other_posts":false,"editor_notices":[],"footnotes":""},"ga4_page_audience":[],"ga4_page_birn_id":[],"ga4_page_branding":[267],"ga4_page_businessunit":[],"ga4_page_campaign":[],"ga4_page_content_purpose":[295],"ga4_page_customer_journey_stage":[323],"ga4_page_customer_specialty":[334],"ga4_page_experience":[],"ga4_page_indication":[],"ga4_page_material_intent":[530],"ga4_page_product":[773],"ga4_page_region":[888],"ga4_page_therapeuticarea":[],"user_role":[],"mhh-area-of-interest":[],"access":[],"user_status":[],"class_list":["post-26","page","type-page","status-publish"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Mechanism of Action (MoA) for BRIDION\u00ae 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