{"id":494,"date":"2026-08-07T16:11:06","date_gmt":"2026-08-07T16:11:06","guid":{"rendered":"https:\/\/www.merckconnect.com\/idvynso\/?page_id=494"},"modified":"2026-08-20T09:06:32","modified_gmt":"2026-08-20T09:06:32","slug":"mechanisms-of-action","status":"publish","type":"page","link":"https:\/\/www.merckconnect.com\/idvynso\/mechanisms-of-action\/","title":{"rendered":"Mechanisms of action"},"content":{"rendered":"\n\n
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IDVYNSOTM<\/sup> (doravirine\/islatravir) is a fixed-dose combination\u2028of 100 mg doravirine and 0.25 mg islatravir with multiple mechanisms of action<\/h1>

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IDVYNSO components and mechanisms of action<\/h2><\/div>\n\n\n\n
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IDVYNSO combines islatravir, a potent next-generation NRTI with multiple mechanisms of action, including translocation inhibition, with doravirine, an NNRTI with an established efficacy and safety profile.<\/p><\/div><\/div>\n\n\n\n

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IDVYNSO mechanisms of action and components<\/title>Diagram showing that IDVYNSO combines two HIV-1 reverse transcriptase inhibitors: doravirine and islatravir. The left side explains that doravirine is a pyridinone non-nucleoside reverse transcriptase inhibitor, or NNRTI, and that it blocks HIV-1 replication by non-competitive inhibition of reverse transcriptase. The right side explains that islatravir is a next-generation deoxyadenosine nucleoside reverse transcriptase inhibitor, or NRTI, that is phosphorylated inside cells to its active form, islatravir-triphosphate. The diagram shows islatravir-triphosphate inhibiting reverse transcriptase in two ways: translocation reverse transcription, where it blocks movement of the enzyme along the viral DNA strand, causing immediate chain termination, and by inducing structural changes in viral DNA that prevent further nucleotide incorporation, causing delayed chain termination.<\/desc><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/rect><\/mask><\/path><\/path><\/path><\/path><\/path><\/g><\/g><\/path><\/mask><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/g><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/g><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/g><\/g><\/path><\/path><\/rect><\/rect><\/g><\/mask><\/path><\/g><\/g><\/rect><\/rect><\/g><\/mask><\/path><\/g><\/g><\/rect><\/rect><\/g><\/mask><\/path><\/g><\/g><\/path><\/path><\/path><\/path><\/rect><\/rect><\/g><\/mask><\/path><\/g><\/g><\/rect><\/rect><\/g><\/mask><\/path><\/g><\/g><\/rect><\/rect><\/g><\/mask><\/path><\/g><\/g><\/path><\/path><\/path><\/path><\/path><\/path><\/rect><\/mask><\/path><\/g><\/g><\/rect><\/rect><\/g><\/mask><\/path><\/g><\/g><\/rect><\/rect><\/g><\/mask><\/path><\/g><\/g><\/rect><\/rect><\/g><\/mask><\/path><\/g><\/g><\/rect><\/rect><\/g><\/mask><\/path><\/g><\/rect><\/rect><\/g><\/mask><\/path><\/g><\/g><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/rect><\/mask><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/g><\/g><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/rect><\/mask><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/g><\/g><\/path><\/rect><\/mask><\/path><\/g><\/g><\/rect><\/rect><\/g><\/mask><\/path><\/g><\/g><\/path><\/rect><\/mask><\/path><\/g><\/g><\/rect><\/rect><\/g><\/mask><\/path><\/g><\/g><\/path><\/path><\/rect><\/mask><\/path><\/path><\/g><\/g><\/path><\/path><\/rect><\/mask><\/path><\/path><\/g><\/g><\/path><\/path><\/rect><\/mask><\/path><\/path><\/g><\/g><\/path><\/path><\/path><\/path><\/path><\/path><\/rect><\/path><\/path><\/mask><\/path><\/path><\/path><\/path><\/rect><\/rect><\/g><\/line><\/path><\/path><\/path><\/rect><\/mask><\/path><\/path><\/g><\/g><\/path><\/path><\/rect><\/mask><\/path><\/path><\/g><\/g><\/path><\/path><\/path><\/path><\/rect><\/mask><\/path><\/path><\/g><\/g><\/path><\/rect><\/mask><\/path><\/g><\/g><\/rect><\/rect><\/g><\/mask><\/path><\/g><\/g><\/rect><\/rect><\/g><\/mask><\/path><\/g><\/g><\/rect><\/rect><\/g><\/mask><\/path><\/g><\/g><\/rect><\/rect><\/g><\/mask><\/path><\/g><\/rect><\/rect><\/g><\/mask><\/path><\/g><\/g><\/path><\/rect><\/path><\/path><\/path><\/rect><\/path><\/rect><\/mask><\/path><\/g><\/g><\/rect><\/rect><\/g><\/mask><\/path><\/g><\/g><\/rect><\/rect><\/g><\/mask><\/path><\/g><\/g><\/rect><\/rect><\/g><\/mask><\/path><\/g><\/g><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/rect><\/mask><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/g><\/g><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/rect><\/mask><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/g><\/g><\/path><\/rect><\/mask><\/path><\/g><\/g><\/rect><\/rect><\/g><\/mask><\/path><\/g><\/g><\/path><\/rect><\/mask><\/path><\/g><\/g><\/rect><\/rect><\/g><\/mask><\/path><\/g><\/g><\/path><\/rect><\/path><\/path><\/rect><\/mask><\/path><\/path><\/g><\/g><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/rect><\/mask><\/path><\/path><\/g><\/g><\/path><\/path><\/rect><\/mask><\/path><\/path><\/g><\/g><\/path><\/path><\/rect><\/mask><\/path><\/path><\/g><\/g><\/path><\/rect><\/mask><\/path><\/g><\/g><\/rect><\/rect><\/g><\/mask><\/path><\/g><\/g><\/rect><\/rect><\/g><\/mask><\/path><\/g><\/g><\/rect><\/rect><\/g><\/mask><\/path><\/g><\/g><\/rect><\/rect><\/g><\/mask><\/path><\/g><\/rect><\/rect><\/g><\/mask><\/path><\/g><\/g><\/path><\/path><\/path><\/rect><\/mask><\/path><\/g><\/g><\/rect><\/rect><\/g><\/mask><\/path><\/g><\/g><\/rect><\/rect><\/g><\/mask><\/path><\/g><\/g><\/rect><\/rect><\/g><\/mask><\/path><\/g><\/g><\/path><\/rect><\/mask><\/path><\/g><\/g><\/rect><\/rect><\/g><\/mask><\/path><\/g><\/g><\/rect><\/rect><\/g><\/mask><\/path><\/g><\/g><\/rect><\/rect><\/g><\/mask><\/path><\/g><\/g><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\/rect><\/mask><\/path><\/path><\/path><\/path><\/path><\/path><\/path><\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IDVYNSO mechanisms of action and components<\/title>Diagram showing that IDVYNSO combines two HIV-1 reverse transcriptase inhibitors: doravirine and islatravir. The left side explains that doravirine is a pyridinone non-nucleoside reverse transcriptase inhibitor, or NNRTI, and that it blocks HIV-1 replication by non-competitive inhibition of reverse transcriptase. The right side explains that islatravir is a next-generation deoxyadenosine nucleoside reverse transcriptase inhibitor, or NRTI, that is phosphorylated inside cells to its active form, islatravir-triphosphate. The diagram shows islatravir-triphosphate inhibiting reverse transcriptase in two ways: translocation reverse transcription, where it blocks movement of the enzyme along the viral DNA strand, causing immediate chain termination, and by inducing structural changes in viral DNA that prevent further nucleotide incorporation, causing delayed chain 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Diagram showing that IDVYNSO combines two HIV-1 reverse transcriptase inhibitors: doravirine and islatravir. The left side explains that doravirine is a pyridinone non-nucleoside reverse transcriptase inhibitor, or NNRTI, and that it blocks HIV-1 replication by non-competitive inhibition of reverse transcriptase. The right side explains that islatravir is a next-generation deoxyadenosine nucleoside reverse transcriptase inhibitor, or NRTI, that is phosphorylated inside cells to its active form, islatravir-triphosphate. The diagram shows islatravir-triphosphate inhibiting reverse transcriptase in two ways: translocation reverse transcription, where it blocks movement of the enzyme along the viral DNA strand, causing immediate chain termination, and nucleotide incorporation reverse transcription, where it causes structural changes in viral DNA that prevent further nucleotide incorporation, causing delayed chain 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<\/div><\/div><\/div>\n\n\n
<\/div>\n\n\n\n

a<\/sup>The IC50 of doravirine for RNA-dependent DNA polymerization of recombinant WT HIV-1 RT in a biochemical assay was 12.2\u00b12.0 nM (n=3). Doravirine does not inhibit the human cellular DNA polymerases \u03b1, \u03b2, and mitochondrial DNA polymerase \u03b3.

b<\/sup>Islatravir-triphosphate inhibited HIV-1 RT in a biochemical assay with an IC50 value of 346\u00b159 nM (n=17). Islatravir-triphosphate does not inhibit human cellular DNA polymerase \u03b2 and mitochondrial DNA polymerase \u03b3. Islatravir-triphosphate shows weak inhibition of human DNA polymerase \u03b1 in a biochemical assay (IC50 value = 29.6 \u03bcM).<\/p>\n\n\n\n

<\/div>\n\n\n\n

Learn more about IDVYNSO<\/strong><\/h2><\/div>\n\n\n\n
<\/div>\n\n\n\n

View clinical data ><\/a><\/strong><\/p><\/div><\/div>\n\n\n\n

<\/div>\n\n\n\n

Abbreviations<\/strong><\/h4><\/div>\n\n\n\n
<\/div>\n\n\n\n

ISL-TP, islatravir-triphosphate; NNRTI, non-nucleoside reverse transcriptase inhibitor; NRTI, nucleoside reverse transcriptase inhibitor; RT, reverse transcriptase.<\/p>\n\n\n\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

IDVYNSO combines islatravir, a potent next-generation NRTI with multiple mechanisms of action, including translocation inhibition, with doravirine, an NNRTI with an established…<\/p>\n","protected":false},"author":4249,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_trash_the_other_posts":false,"editor_notices":[],"footnotes":""},"ga4_page_audience":[247],"ga4_page_birn_id":[],"ga4_page_branding":[264],"ga4_page_businessunit":[],"ga4_page_campaign":[],"ga4_page_content_purpose":[300],"ga4_page_customer_journey_stage":[341],"ga4_page_customer_specialty":[366],"ga4_page_experience":[],"ga4_page_indication":[471],"ga4_page_material_intent":[563],"ga4_page_product":[616],"ga4_page_region":[793],"ga4_page_therapeuticarea":[839],"user_role":[],"mhh-area-of-interest":[],"access":[],"user_status":[],"class_list":["post-494","page","type-page","status-publish"],"yoast_head":"\nMechanisms of Action for 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