{"id":500,"date":"2026-08-06T11:35:07","date_gmt":"2026-08-06T11:35:07","guid":{"rendered":"https:\/\/www.merckconnect.com\/idvynso\/?page_id=500"},"modified":"2026-08-20T08:35:39","modified_gmt":"2026-08-20T08:35:39","slug":"dosing-administration","status":"publish","type":"page","link":"https:\/\/www.merckconnect.com\/idvynso\/dosing-administration\/","title":{"rendered":"Dosing &amp; administration"},"content":{"rendered":"<link rel='stylesheet' id='vivid360-spacer-css-css' href='https:\/\/www.merckconnect.com\/idvynso\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/spacer\/css\/style.min.css?ver=1764595895' media='all' \/>\n\n<div style=\"background-color:transparent;--desktop-spacer:0px;--tablet-spacer:0px;--mobile-spacer:24px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n<link rel='stylesheet' id='vivid360-hero-css-css' href='https:\/\/www.merckconnect.com\/idvynso\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/hero\/css\/style.min.css?ver=1785923742' media='all' \/>\n\n<div id=\"\" class=\"wp-block-vivid360-hero\"><div class=\"vivid360-hero-container align-left align-middle ratio-70-30 horizontal mobile text-align-left is-default-style mobile-uses-desktop-styles\" style=\"border-width:0;border-style:solid;border-top-left-radius:0;border-top-right-radius:0;border-bottom-right-radius:0;border-bottom-left-radius:0;color:#092e49;--minHeight:218px;--mobileMinHeight:281px;--videoOpacity:0.6\" data-desktop-autoplay=\"true\" data-mobile-autoplay=\"true\" data-desktop-playback-mode=\"loop\" data-mobile-playback-mode=\"loop\"><div class=\"wide_screens hidden\" data-value=\"default\"><\/div><picture><source media=\"(max-width: 767px)\" srcset=\"https:\/\/www.merckconnect.com\/idvynso\/wp-content\/uploads\/sites\/338\/2026\/08\/Full-Overlay-mob-1_f52b85.png?w=767\"\/><source media=\"(min-width: 768px) and (max-width: 1024px)\" srcset=\"https:\/\/www.merckconnect.com\/idvynso\/wp-content\/uploads\/sites\/338\/2026\/08\/Full-Overlay-mob-1_f52b85.png?w=1024\"\/><source media=\"(min-width: 1025px) and (max-width:1440px)\" srcset=\"https:\/\/www.merckconnect.com\/idvynso\/wp-content\/uploads\/sites\/338\/2026\/08\/Full-Overlay-dosing-desk.png?w=1440\"\/><img decoding=\"async\" width=\"1128\" height=\"218\" loading=\"lazy\" data-src=\"https:\/\/www.merckconnect.com\/idvynso\/wp-content\/uploads\/sites\/338\/2026\/08\/Full-Overlay-dosing-desk.png?w=1163\" src=\"https:\/\/www.merckconnect.com\/idvynso\/wp-content\/uploads\/sites\/338\/2026\/08\/Full-Overlay-dosing-desk.png?w=1163\" alt=\"\" class=\"hero-image\" style=\"--desktop-focal-x:50%;--desktop-focal-y:50%;--mobile-focal-x:50%;--mobile-focal-y:0%;--tablet-focal-x:50%;--tablet-focal-y:0%\"\/><\/picture><div class=\"hero-wrapper\"><div class=\"hero-content\"><h1 style=\"--headlineFontSize:36px;--headlineFontSizeTablet:36px;--headlineFontSizeMobile:20px;--headlineLineHeight:45px;--headlineLineHeightTablet:45px;--headlineLineHeightMobile:30px\" class=\"hero-title fontWeightBold\">IDVYNSO<sup>TM<\/sup> (doravirine\/islatravir) dosing &amp; administration<\/h1><p class=\"hero-description\"><\/p><div class=\"hero-btn-group\"><\/div><div class=\"hero-caption\"><\/div><\/div><\/div><\/div><div class=\"hero-caption-2mobile\"><\/div><div id=\"video-a11y-announcer\" aria-live=\"polite\" aria-atomic=\"true\" style=\"position:absolute; left:-9999px;\"><\/div><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:26px;--mobile-spacer:26px;--tablet-spacer:26px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-mobile vivid360-spacer-tablet\"><\/div>\n\n\n<link rel='stylesheet' id='vivid360-columns-css-css' href='https:\/\/www.merckconnect.com\/idvynso\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/columns\/css\/style.min.css?ver=1765551955' media='all' \/>\n\n<div class=\"wp-block-vivid360-columns vivid360-columns are-vertically-aligned-center not-stacked-on-tablet mb-0\" style=\"--desktopPadding:;--tabletPadding:;--mobilePadding:;--gutterWidth:24px;--mobGutterWidth:24px;border-style:;border-radius:0;border-width:0\"><link rel='stylesheet' id='vivid360-column-css-css' href='https:\/\/www.merckconnect.com\/idvynso\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/column\/css\/style.min.css?ver=1765551955' media='all' \/>\n\n<div class=\"wp-block-vivid360-column is-vertically-aligned-center vivid360-column\" style=\"--tabletColumnWidth:33.33%;--mobileColumnWidth:33.33%;--tabletColumnOrder:;--mobileColumnOrder:;--colDeskPadding:;--colTabPadding:;--colMobPadding:;flex-basis:33.33%;border-style:;border-radius:0;border-width:0\"><link rel='stylesheet' id='vivid360-image-css-css' href='https:\/\/www.merckconnect.com\/idvynso\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/image\/css\/style.min.css?ver=1783495742' media='all' \/>\n\n<div class=\"wp-block-vivid360-image img-container mt-0 mr-0 mb-0 ml-0\"><figure class=\"wp-block-vivid360-image is-style-default has-mobile-image size-large is-resized\"><img decoding=\"async\" src=\"https:\/\/www.merckconnect.com\/idvynso\/wp-content\/uploads\/sites\/338\/2026\/08\/bottle_image_919b58.svg\" alt=\"IDVYNSO\u2122 (doravirine\/islatravir) 100 mg\/0.25 mg Tablets\" class=\"wp-image-604  style-noshadow   \" height=\"177\" title=\"bottle_image\" style=\"height:177px;width:360px\" srcset=\"https:\/\/www.merckconnect.com\/idvynso\/wp-content\/uploads\/sites\/338\/\/2026\/08\/bottle_image_919b58.svg 360w, https:\/\/www.merckconnect.com\/idvynso\/wp-content\/uploads\/sites\/338\/\/2026\/08\/bottle_image_919b58.svg?resize=300,207 300w\" sizes=\"(max-width: 360px) 100vw, 360px\" \/><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.merckconnect.com\/idvynso\/wp-content\/uploads\/sites\/338\/2026\/08\/Images-4x.png\" alt=\"IDVYNSO\u2122 (doravirine\/islatravir) 100 mg\/0.25 mg Tablets\" class=\"wp-image-742  style-noshadow mobile-image  mobWidthAuto \" width=\"360\" height=\"230\" title=\"Images-4x\" style=\"height:230px;width:360px\"\/><\/figure><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:8px;--mobile-spacer:16px;--tablet-spacer:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-mobile vivid360-spacer-tablet\"><\/div>\n\n\n\n<p class=\"has-text-align-center has-dark-text-color has-text-color has-link-color has-small-font-size wp-elements-a4bd3ff67f016c301f501bc464c12dde\">Tablet not shown at actual size<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-vivid360-column is-vertically-aligned-center vivid360-column\" style=\"--tabletColumnWidth:66.66%;--mobileColumnWidth:66.66%;--tabletColumnOrder:;--mobileColumnOrder:;--colDeskPadding:;--colTabPadding:;--colMobPadding:;flex-basis:66.66%;border-style:;border-radius:0;border-width:0\"><link rel='stylesheet' id='vivid360-heading-css-css' href='https:\/\/www.merckconnect.com\/idvynso\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/heading\/css\/style.min.css?ver=1764595895' media='all' \/>\n\n<div class=\"vivid360-heading default-hcp-tablet-fontsize\" id=\"acdecb41f-b4e4-44ba-977a-4615d59e982a\"><h2 class=\"content-width fontWeightBold mt-0 mb-0\" style=\"color:#092e49;--desktopFontSize:24px;--tabletFontSize:var(--h2FontSizeDesktop);--mobileFontSize:20px;--desktopLineHeightSize:36px;--tabletLineHeightSize:var(--h2LineHeightDesktop);--mobileLineHeightSize:\" id=\"\">IDVYNSO dosing &amp; administration<\/h2><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:24px;--mobile-spacer:24px;--tablet-spacer:24px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-mobile vivid360-spacer-tablet\"><\/div>\n\n\n\n<p class=\"has-dark-text-color has-text-color has-link-color has-regular-font-size wp-elements-70d565eaa2c56119ceb53f76f9a2dada\">The recommended dosage of IDVYNSO is one tablet containing <span class=\"no-wrap-text\">100 mg<\/span> of doravirine and <span class=\"no-wrap-text\">0.25 mg<\/span>\u2028of islatravir orally <strong>once daily with or without food.<\/strong><\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:56px;--mobile-spacer:64px;--tablet-spacer:56px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-mobile vivid360-spacer-tablet\"><\/div>\n\n\n\n<div class=\"wp-block-vivid360-columns vivid360-columns not-stacked-on-tablet mb-0 items-justified-center\" style=\"--desktopPadding:;--tabletPadding:;--mobilePadding:;--gutterWidth:50px;--mobGutterWidth:16px;border-style:;border-radius:0;border-width:0\">\n<div class=\"wp-block-vivid360-column vivid360-column\" style=\"--tabletColumnWidth:230px;--mobileColumnWidth:230px;--tabletColumnOrder:;--mobileColumnOrder:;--colDeskPadding:;--colTabPadding:;--colMobPadding:;flex-basis:230px;border-style:;border-radius:0;border-width:0\">\n<div class=\"wp-block-vivid360-image img-container mt-0 mb-0 ml-0 mr-0 figurealigncenter img\"><figure class=\"wp-block-vivid360-image is-style-default has-mobile-image size-large\"><img decoding=\"async\" src=\"https:\/\/www.merckconnect.com\/idvynso\/wp-content\/uploads\/sites\/338\/2026\/08\/ONE-TABLET.svg\" alt=\"The Recommended Dosage of IDVYNSO\u2122 (doravirine\/islatravir) Is One Tablet\" class=\"wp-image-4174  style-noshadow   \" title=\"ONE TABLET\" style=\"height:295px;width:230px\"\/><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.merckconnect.com\/idvynso\/wp-content\/uploads\/sites\/338\/2026\/08\/ONE-TABLET-1.svg\" alt=\"The Recommended Dosage of IDVYNSO\u2122 (doravirine\/islatravir) Is One Tablet\" class=\"wp-image-4175  style-noshadow mobile-image mobHeightAuto mobWidthAuto \" width=\"360\" height=\"135\" title=\"ONE TABLET (1)\" style=\"height:135px;width:360px\"\/><\/figure><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-vivid360-column vivid360-column\" style=\"--tabletColumnWidth:230px;--mobileColumnWidth:230px;--tabletColumnOrder:;--mobileColumnOrder:;--colDeskPadding:;--colTabPadding:;--colMobPadding:;flex-basis:230px;border-style:;border-radius:0;border-width:0\">\n<div class=\"wp-block-vivid360-image img-container mt-0 mb-0 ml-0 mr-0\"><figure class=\"wp-block-vivid360-image is-style-default has-mobile-image size-large\"><img decoding=\"async\" src=\"https:\/\/www.merckconnect.com\/idvynso\/wp-content\/uploads\/sites\/338\/2026\/08\/ONCE-DAILY.svg\" alt=\"Once-Daily, Non-INSTI, Fixed-Dose Combination Regimen May Be Taken Any Time of Day at About the Same Time Every Day\" class=\"wp-image-4173  style-noshadow   \" title=\"ONCE DAILY\" style=\"height:295px;width:230px\"\/><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.merckconnect.com\/idvynso\/wp-content\/uploads\/sites\/338\/2026\/08\/ONCE-DAILY-1.svg\" alt=\"Once-Daily, Non-INSTI, Fixed-Dose Combination Regimen May Be Taken Any Time of Day at About the Same Time Every Day\" class=\"wp-image-4176  style-noshadow mobile-image mobHeightAuto mobWidthAuto \" width=\"360\" height=\"135\" title=\"ONCE DAILY (1)\" style=\"height:135px;width:360px\"\/><\/figure><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-vivid360-column vivid360-column\" style=\"--tabletColumnWidth:230px;--mobileColumnWidth:230px;--tabletColumnOrder:;--mobileColumnOrder:;--colDeskPadding:;--colTabPadding:;--colMobPadding:;flex-basis:230px;border-style:;border-radius:0;border-width:0\">\n<div class=\"wp-block-vivid360-image img-container mt-0 mb-0 ml-0 mr-0\"><figure class=\"wp-block-vivid360-image is-style-default has-mobile-image size-large\"><img decoding=\"async\" src=\"https:\/\/www.merckconnect.com\/idvynso\/wp-content\/uploads\/sites\/338\/2026\/08\/FOOD-RESTRICTIONS.svg\" alt=\"IDVYNSO\u2122 (doravirine\/islatravir) Can be Taken With or Without Food\" class=\"wp-image-4172  style-noshadow   \" title=\"FOOD RESTRICTIONS\" style=\"height:295px;width:230px\"\/><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.merckconnect.com\/idvynso\/wp-content\/uploads\/sites\/338\/2026\/08\/FOOD-RESTRICTIONS-1.svg\" alt=\"IDVYNSO\u2122 (doravirine\/islatravir) Can be Taken With or Without Food\" class=\"wp-image-4177  style-noshadow mobile-image mobHeightAuto mobWidthAuto \" width=\"360\" height=\"135\" title=\"FOOD RESTRICTIONS (1)\" style=\"height:135px;width:360px\"\/><\/figure><\/div>\n<\/div>\n<\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:46px;--mobile-spacer:46px;--tablet-spacer:46px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-mobile vivid360-spacer-tablet\"><\/div>\n\n\n\n<p class=\"has-dark-text-color has-text-color has-link-color has-regular-font-size wp-elements-5e36498bb1fe962e2c9779c3b9a1e772\">Each IDVYNSO tablet is pink, oval-shaped and film-coated, and is debossed with 772 on one side and plain on the other side. Each bottle contains 30 tablets.<\/p>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:24px;--mobile-spacer:24px;--tablet-spacer:24px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-mobile vivid360-spacer-tablet\"><\/div>\n\n\n\n<p class=\"has-primary-color has-text-color has-link-color has-regular-font-size wp-elements-7dd1bfae890d52c7f6b6f59ba7756168\"><strong><a href=\"https:\/\/www.merckconnect.com\/idvynso\/discontinuation-rate\/\" aria-label=\"#\">View IDVYNSO safety &amp; tolerability <span class=\"no-wrap-text\">information &gt;<\/span><\/a><\/strong><\/p>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:40px;--mobile-spacer:40px;--tablet-spacer:40px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-mobile vivid360-spacer-tablet\"><\/div>\n\n\n\n<p class=\"has-text-color has-link-color has-small-font-size wp-elements-d5f5bd6955404ed50025c9515c302ffc\" style=\"color:#0d251e\"><sup>a<\/sup>If IDVYNSO is co-administered with rifabutin, take one tablet of IDVYNSO once daily as recommended, followed by one tablet of doravirine (PIFELTRO\u00ae)\u2028<span class=\"no-wrap-text\">100 mg<\/span> approximately 12 hours after the dose of IDVYNSO for the duration of rifabutin co-administration.<\/p>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:32px;--mobile-spacer:32px;--tablet-spacer:32px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-mobile vivid360-spacer-tablet\"><\/div>\n\n\n<link rel='stylesheet' id='vivid360-separator-css-css' href='https:\/\/www.merckconnect.com\/idvynso\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/separator\/css\/style.min.css?ver=1764595895' media='all' \/>\n\n<hr class=\"wp-block-vivid360-separator has-text-color has-background has-primary-background-color has-primary-color content-width\" style=\"height:0\"\/>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:16px;--mobile-spacer:16px;--tablet-spacer:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-mobile vivid360-spacer-tablet\"><\/div>\n\n\n\n<div class=\"vivid360-heading default-hcp-tablet-fontsize\" id=\"ad5580e77-7712-4194-8401-03e9ae175bef\"><h2 class=\"has-dark-text-color content-width fontWeightBold mt-0 mb-0\" style=\"--desktopFontSize:24px;--tabletFontSize:var(--h2FontSizeDesktop);--mobileFontSize:20px;--desktopLineHeightSize:36px;--tabletLineHeightSize:var(--h2LineHeightDesktop);--mobileLineHeightSize:\" id=\"\">Want to learn about the IDVYNSO clinical trials?<\/h2><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:24px;--mobile-spacer:24px;--tablet-spacer:24px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-mobile vivid360-spacer-tablet\"><\/div>\n\n\n\n<p class=\"has-primary-color has-text-color has-link-color has-regular-font-size wp-elements-18cfd3bd305ebb9f8291c294236bdd18\"><strong><a href=\"https:\/\/www.merckconnect.com\/idvynso\/trial-052-study-design\/\" type=\"link\" id=\"https:\/\/www.merckconnect.com\/idvynso\/trial-052-efficacy-data\" aria-label=\"#\">Review Trial 052 data &gt;<\/a><\/strong><\/p>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:32px;--mobile-spacer:32px;--tablet-spacer:32px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-mobile vivid360-spacer-tablet\"><\/div>\n\n\n\n<p class=\"has-primary-color has-text-color has-link-color has-regular-font-size wp-elements-6c6cda58c9a0dd8221ee6db16e408e9a\"><strong><a href=\"https:\/\/www.merckconnect.com\/idvynso\/trial-051-study-design\/\" aria-label=\"#\">Review Trial 051 data &gt;<\/a><\/strong><\/p>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:48px;--mobile-spacer:48px;--tablet-spacer:48px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-mobile vivid360-spacer-tablet\"><\/div>\n\n\n\n<div class=\"vivid360-heading\" id=\"a4cd2c006-0a63-4ae8-b4cd-0ad21fcd19c4\"><h4 class=\"has-dark-text-color content-width fontWeightRegular mt-0 mb-0\" style=\"--desktopFontSize:18px;--tabletFontSize:var(--h4FontSizeDesktop);--mobileFontSize:16px;--desktopLineHeightSize:27px;--tabletLineHeightSize:var(--h4LineHeightDesktop);--mobileLineHeightSize:\" id=\"\"><strong>Abbreviations<\/strong><\/h4><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:16px;--mobile-spacer:16px;--tablet-spacer:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-mobile vivid360-spacer-tablet\"><\/div>\n\n\n\n<p class=\"has-dark-text-color has-text-color has-link-color has-regular-font-size wp-elements-b4061e69f7935825190c6863e71874d0\">INSTI, integrase strand transfer inhibitor.<\/p>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:24px;--mobile-spacer:16px;--tablet-spacer:24px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-mobile vivid360-spacer-tablet\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Each IDVYNSO tablet is pink, oval-shaped and film-coated, and is debossed with 772 on one side and plain on the other side&#8230;.<\/p>\n","protected":false},"author":4249,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_trash_the_other_posts":false,"editor_notices":[],"footnotes":""},"ga4_page_audience":[247],"ga4_page_birn_id":[],"ga4_page_branding":[264],"ga4_page_businessunit":[],"ga4_page_campaign":[],"ga4_page_content_purpose":[286],"ga4_page_customer_journey_stage":[341],"ga4_page_customer_specialty":[366],"ga4_page_experience":[],"ga4_page_indication":[471],"ga4_page_material_intent":[563],"ga4_page_product":[616],"ga4_page_region":[793],"ga4_page_therapeuticarea":[839],"user_role":[],"mhh-area-of-interest":[],"access":[],"user_status":[],"class_list":["post-500","page","type-page","status-publish"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Dosing and Administration for IDVYNSO\u2122 (doravirine\/islatravir)<\/title>\n<meta name=\"description\" content=\"Review the dosing and administration information for IDVYNSO\u2122 (doravirine\/islatravir). 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