{"id":538,"date":"2026-08-06T13:57:57","date_gmt":"2026-08-06T13:57:57","guid":{"rendered":"https:\/\/www.merckconnect.com\/idvynso\/?page_id=538"},"modified":"2026-08-20T09:18:24","modified_gmt":"2026-08-20T09:18:24","slug":"resistance-profile","status":"publish","type":"page","link":"https:\/\/www.merckconnect.com\/idvynso\/resistance-profile\/","title":{"rendered":"Trail 052 & Trail 051 Resistance profile"},"content":{"rendered":"\n\n
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Resistance data in participants who received IDVYNSOTM<\/sup> (doravirine\/islatravir) across Trials 052 and 051<\/h1>

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IDVYNSO resistance profile<\/h2><\/div>\n\n\n\n
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a<\/sup>Resistance-associated substitutions: T69T\/S, K70K\/R, K101K\/E, K103K\/N, and M184M\/V at baseline and K103N, M184V, H221Y, M230L, and L234I at Week 24.\u2028
b<\/sup>Resistance-associated substitutions: M41L, V106V\/I, Y181Y\/C, M184M\/V, and T215E.<\/p>\n\n\n\n

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Data in participants with resistance-associated substitutions at baseline<\/strong><\/h2><\/div>\n\n\n\n
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Participants in Trial 052 and Trial 051 were randomized 2:1 with 708 participants receiving IDVYNSO.<\/strong><\/p><\/div><\/div>\n\n\n\n

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Learn more about Trial 052<\/h2><\/div>\n\n\n\n
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Review the Safety & Tolerability profile ><\/a><\/strong><\/p>\n\n\n\n

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Explore Trial 051 data<\/strong><\/h2><\/div>\n\n\n\n
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Review clinical trial data here<\/strong> ><\/a><\/strong><\/p><\/div><\/div>\n\n\n\n

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Abbreviations<\/strong><\/h4><\/div>\n\n\n\n
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ARV, antiretroviral; BIC, bictegravir; FTC, emtricitabine; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; NNRTI, non-nucleoside reverse transcriptase inhibitor; PLWH, person(s) living with HIV; RNA, ribonucleic acid; TAF, tenofovir alafenamide.<\/p><\/div><\/div>\n\n\n\n

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aResistance-associated substitutions: T69T\/S, K70K\/R, K101K\/E, K103K\/N, and M184M\/V at baseline and K103N, M184V, H221Y, M230L, and L234I at Week 24.\u2028bResistance-associated substitutions: M41L,…<\/p>\n","protected":false},"author":4249,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_trash_the_other_posts":false,"editor_notices":[],"footnotes":""},"ga4_page_audience":[247],"ga4_page_birn_id":[],"ga4_page_branding":[264],"ga4_page_businessunit":[],"ga4_page_campaign":[],"ga4_page_content_purpose":[328],"ga4_page_customer_journey_stage":[341],"ga4_page_customer_specialty":[366],"ga4_page_experience":[],"ga4_page_indication":[471],"ga4_page_material_intent":[563],"ga4_page_product":[616],"ga4_page_region":[793],"ga4_page_therapeuticarea":[839],"user_role":[],"mhh-area-of-interest":[],"access":[],"user_status":[],"class_list":["post-538","page","type-page","status-publish"],"yoast_head":"\nResistance Profile for IDVYNSO\u2122 (doravirine\/islatravir)<\/title>\n<meta name=\"description\" content=\"Review the resistance profile for IDVYNSO\u2122 (doravirine\/islatravir) in Trial 052 and 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