{"id":547,"date":"2026-08-06T15:25:06","date_gmt":"2026-08-06T15:25:06","guid":{"rendered":"https:\/\/www.merckconnect.com\/idvynso\/?page_id=547"},"modified":"2026-08-20T08:49:24","modified_gmt":"2026-08-20T08:49:24","slug":"plwh-profile-1","status":"publish","type":"page","link":"https:\/\/www.merckconnect.com\/idvynso\/plwh-profile-1\/","title":{"rendered":"PLWH profile 1"},"content":{"rendered":"<link rel='stylesheet' id='vivid360-spacer-css-css' href='https:\/\/www.merckconnect.com\/idvynso\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/spacer\/css\/style.min.css?ver=1775653743' media='all' \/>\n\n<div style=\"background-color:transparent;height:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-8\"><\/div>\n\n\n<link rel='stylesheet' id='vivid360-hero-css-css' href='https:\/\/www.merckconnect.com\/idvynso\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/hero\/css\/style.min.css?ver=1785934614' media='all' \/>\n\n<div id=\"\" class=\"wp-block-vivid360-hero\"><div class=\"vivid360-hero-container align-left align-middle ratio-70-30 horizontal mobile text-align-left is-default-style mobile-uses-desktop-styles\" style=\"border-width:0;border-style:solid;border-top-left-radius:0;border-top-right-radius:0;border-bottom-right-radius:0;border-bottom-left-radius:0;color:#092e49;--minHeight:218px;--mobileMinHeight:281px\"><div class=\"wide_screens hidden\" data-value=\"default\"><\/div><picture><source media=\"(max-width: 767px)\" srcset=\"https:\/\/www.merckconnect.com\/idvynso\/wp-content\/uploads\/sites\/338\/2026\/08\/Full-Overlay-mob-1.png?w=767\"\/><source media=\"(min-width: 768px) and (max-width: 1024px)\" srcset=\"https:\/\/www.merckconnect.com\/idvynso\/wp-content\/uploads\/sites\/338\/2026\/08\/Full-Overlay-mob-1.png?w=1024\"\/><source media=\"(min-width: 1025px) and (max-width:1440px)\" srcset=\"https:\/\/www.merckconnect.com\/idvynso\/wp-content\/uploads\/sites\/338\/2026\/08\/Full-Overlay-desk_d25180.png?w=1440\"\/><img decoding=\"async\" width=\"1128\" height=\"218\" loading=\"lazy\" data-src=\"https:\/\/www.merckconnect.com\/idvynso\/wp-content\/uploads\/sites\/338\/2026\/08\/Full-Overlay-desk_d25180.png?w=1232\" src=\"https:\/\/www.merckconnect.com\/idvynso\/wp-content\/uploads\/sites\/338\/2026\/08\/Full-Overlay-desk_d25180.png?w=1232\" alt=\"\" class=\"hero-image\" style=\"--desktop-focal-x:50%;--desktop-focal-y:50%;--mobile-focal-x:50%;--mobile-focal-y:0%;--tablet-focal-x:50%;--tablet-focal-y:0%\"\/><\/picture><div class=\"hero-wrapper\"><div class=\"hero-content\"><h1 style=\"--headlineFontSize:36px;--headlineFontSizeTablet:36px;--headlineFontSizeMobile:20px;--headlineLineHeight:45px;--headlineLineHeightTablet:45px;--headlineLineHeightMobile:30px\" class=\"hero-title fontWeightBold\">Clinical scenario: potential switch from an oral INSTI-based regimen<\/h1><p class=\"hero-description\"><\/p><div class=\"hero-btn-group\"><\/div><div class=\"hero-caption\"><\/div><\/div><\/div><\/div><div class=\"hero-caption-2mobile\"><\/div><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:48px;--tablet-spacer:48px;--mobile-spacer:32px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n<link rel='stylesheet' id='vivid360-heading-css-css' href='https:\/\/www.merckconnect.com\/idvynso\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/heading\/css\/style.min.css?ver=1775653743' media='all' \/>\n\n<div class=\"vivid360-heading default-hcp-tablet-fontsize\" id=\"a4b0149bc-eece-487d-b58a-03d04cbb8124\"><h2 class=\"content-width fontWeightRegular mt-0 mb-0\" style=\"color:#092e49;--desktopFontSize:24px;--tabletFontSize:var(--h2FontSizeDesktop);--mobileFontSize:20px;--desktopLineHeightSize:36px;--tabletLineHeightSize:var(--h2LineHeightDesktop);--mobileLineHeightSize:\" id=\"\"><strong>HIV-1 viral load:<\/strong> Virologically suppressed first diagnosed with HIV <span class=\"no-wrap-text\">22 years ago<\/span><\/h2><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:40px;--tablet-spacer:40px;--mobile-spacer:40px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n<link rel='stylesheet' id='vivid360-columns-css-css' href='https:\/\/www.merckconnect.com\/idvynso\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/columns\/css\/style.min.css?ver=1775653743' media='all' \/>\n\n<div class=\"wp-block-vivid360-columns vivid360-columns are-vertically-aligned-top not-stacked-on-tablet mb-0\" style=\"--desktopPadding:;--tabletPadding:;--mobilePadding:;--gutterWidth:24px;--mobGutterWidth:24px;border-style:;border-radius:0;border-width:0\"><link rel='stylesheet' id='vivid360-column-css-css' href='https:\/\/www.merckconnect.com\/idvynso\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/column\/css\/style.min.css?ver=1775653743' media='all' \/>\n\n<div class=\"wp-block-vivid360-column is-vertically-aligned-top vivid360-column\" style=\"--tabletColumnWidth:264px;--mobileColumnWidth:264px;--tabletColumnOrder:;--mobileColumnOrder:;--colDeskPadding:;--colTabPadding:;--colMobPadding:;flex-basis:264px;border-style:;border-radius:0;border-width:0\"><link rel='stylesheet' id='vivid360-image-css-css' href='https:\/\/www.merckconnect.com\/idvynso\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/image\/css\/style.min.css?ver=1783718418' media='all' \/>\n\n<div class=\"wp-block-vivid360-image img-container mt-0 mb-0 mr-0 ml-0\"><figure class=\"wp-block-vivid360-image is-style-default has-mobile-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"792\" height=\"732\" src=\"https:\/\/www.merckconnect.com\/idvynso\/wp-content\/uploads\/sites\/338\/2026\/08\/image-3.png\" alt=\"\" class=\"wp-image-548  style-noshadow deskHeightAuto  \" title=\"image-3\" style=\"height:732px;width:792px\" srcset=\"https:\/\/www.merckconnect.com\/idvynso\/wp-content\/uploads\/sites\/338\/2026\/08\/image-3.png 792w, https:\/\/www.merckconnect.com\/idvynso\/wp-content\/uploads\/sites\/338\/2026\/08\/image-3.png?resize=300,277 300w, https:\/\/www.merckconnect.com\/idvynso\/wp-content\/uploads\/sites\/338\/2026\/08\/image-3.png?resize=768,710 768w\" sizes=\"auto, (max-width: 792px) 100vw, 792px\" \/><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.merckconnect.com\/idvynso\/wp-content\/uploads\/sites\/338\/2026\/08\/Images.png\" alt=\"\" class=\"wp-image-549  style-noshadow mobile-image mobHeightAuto  \" width=\"358\" height=\"324\" title=\"Images\" style=\"height:324px;width:358px\" srcset=\"https:\/\/www.merckconnect.com\/idvynso\/wp-content\/uploads\/sites\/338\/2026\/08\/Images.png 1074w, https:\/\/www.merckconnect.com\/idvynso\/wp-content\/uploads\/sites\/338\/2026\/08\/Images.png?resize=300,272 300w, https:\/\/www.merckconnect.com\/idvynso\/wp-content\/uploads\/sites\/338\/2026\/08\/Images.png?resize=768,695 768w, https:\/\/www.merckconnect.com\/idvynso\/wp-content\/uploads\/sites\/338\/2026\/08\/Images.png?resize=1024,927 1024w\" sizes=\"auto, (max-width: 358px) 100vw, 358px\" \/><\/figure><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-vivid360-column is-vertically-aligned-top vivid360-column\" style=\"--tabletColumnWidth:35.5%;--mobileColumnWidth:35.5%;--tabletColumnOrder:;--mobileColumnOrder:;--colDeskPadding:;--colTabPadding:;--colMobPadding:;flex-basis:35.5%;border-style:;border-radius:0;border-width:0\">\n<div class=\"vivid360-heading default-hcp-tablet-fontsize\" id=\"aebe36c3c-3cc3-46bf-bfbe-7067e0152d38\"><h2 class=\"has-primary-color content-width fontWeightBold mt-0 mb-0\" style=\"--desktopFontSize:24px;--tabletFontSize:var(--h2FontSizeDesktop);--mobileFontSize:20px;--desktopLineHeightSize:36px;--tabletLineHeightSize:var(--h2LineHeightDesktop);--mobileLineHeightSize:\" id=\"\">Medical History:<\/h2><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:24px;--tablet-spacer:24px;--mobile-spacer:24px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n<link rel='stylesheet' id='vivid360-list-parent-css-css' href='https:\/\/www.merckconnect.com\/idvynso\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/list-parent\/css\/style.css?ver=1775653743' media='all' \/>\n\n<div class=\"vivid-block-list2 content-width  \">\n<ul style=\"--listBulletColor:#333\" class=\"list-bullet-color mt-0 mb-0 has-dark-text-color has-text-color has-link-color has-regular-font-size wp-elements-5424b20c09723f9c9592eb56f8406276\">\n<li class=\"mt-0 mb-0\">Age 50<\/li>\n\n\n\n<li class=\"mt-0 mb-0\">Virologically suppressed on an INSTI-based \u2028regimen <span class=\"no-wrap-text\">(24 mos.)<\/span><\/li>\n\n\n\n<li class=\"mt-0 mb-0\">No history of treatment failure<\/li>\n\n\n\n<li class=\"mt-0 mb-0\">Overweight (BMI \u2013 <span class=\"no-wrap-text\">28 kg\/m<sup>2<\/sup><\/span>)\u200b<\/li>\n\n\n\n<li class=\"mt-0 mb-0\">Type 2 diabetes<\/li>\n\n\n\n<li class=\"mt-0 mb-0\">Diagnosed with dyslipidemia<\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-vivid360-column is-vertically-aligned-top vivid360-column\" style=\"--tabletColumnWidth:34.5%;--mobileColumnWidth:34.5%;--tabletColumnOrder:;--mobileColumnOrder:;--colDeskPadding:;--colTabPadding:;--colMobPadding:;flex-basis:34.5%;border-style:;border-radius:0;border-width:0\">\n<div class=\"vivid360-heading default-hcp-tablet-fontsize\" id=\"abc27789f-a4e0-453c-ba03-ef7e22f3397f\"><h2 class=\"has-primary-color content-width fontWeightBold mt-0 mb-0\" style=\"--desktopFontSize:24px;--tabletFontSize:var(--h2FontSizeDesktop);--mobileFontSize:20px;--desktopLineHeightSize:36px;--tabletLineHeightSize:var(--h2LineHeightDesktop);--mobileLineHeightSize:\" id=\"\">Non-ART Medications:<\/h2><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:24px;--tablet-spacer:24px;--mobile-spacer:24px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<div class=\"vivid-block-list2 content-width  \">\n<ul style=\"--listBulletColor:#333\" class=\"list-bullet-color mt-0 mb-0 has-dark-text-color has-text-color has-link-color has-regular-font-size wp-elements-aac7c9616c0ea6e8b08ab41d98aadcc2\">\n<li class=\"mt-0 mb-0\">Statin<\/li>\n\n\n\n<li class=\"mt-0 mb-0\">Metformin<\/li>\n<\/ul>\n<\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:16px;--tablet-spacer:16px;--mobile-spacer:16px;height:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<div class=\"vivid360-heading default-hcp-tablet-fontsize\" id=\"ae1a50e2c-42af-4f0b-8094-31ec7559667c\"><h2 class=\"has-primary-color content-width fontWeightBold mt-0 mb-0\" style=\"--desktopFontSize:24px;--tabletFontSize:var(--h2FontSizeDesktop);--mobileFontSize:20px;--desktopLineHeightSize:36px;--tabletLineHeightSize:var(--h2LineHeightDesktop);--mobileLineHeightSize:\" id=\"\">Concerns:<\/h2><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:24px;--tablet-spacer:24px;--mobile-spacer:24px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<div class=\"vivid-block-list2 content-width  \">\n<ul style=\"--listBulletColor:#333\" class=\"list-bullet-color mt-0 mb-0 has-dark-text-color has-text-color has-link-color has-regular-font-size wp-elements-bfc2affffa1b8a1cfcde1cb788a20cd7\">\n<li class=\"mt-0 mb-0\">Concerned about gaining any additional weight\u200b<\/li>\n\n\n\n<li class=\"mt-0 mb-0\">Disturbed sleep began after starting an INSTI-\u2028based regimen<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:32px;--tablet-spacer:32px;--mobile-spacer:32px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n<link rel='stylesheet' id='vivid360-separator-css-css' href='https:\/\/www.merckconnect.com\/idvynso\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/separator\/css\/style.min.css?ver=1775653743' media='all' \/>\n\n<hr class=\"wp-block-vivid360-separator has-text-color has-background has-primary-background-color has-primary-color desktopwidth mobileWidth\" style=\"height:0;--desktopwidth:66%;--mobileWidth:100%\"\/>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:16px;--tablet-spacer:16px;--mobile-spacer:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<div class=\"vivid360-heading default-hcp-tablet-fontsize\" id=\"a2f426240-3482-4772-b091-e64fb07e5c03\"><h2 class=\"has-dark-text-color content-width fontWeightBold mt-0 mb-0\" style=\"--desktopFontSize:24px;--tabletFontSize:var(--h2FontSizeDesktop);--mobileFontSize:20px;--desktopLineHeightSize:36px;--tabletLineHeightSize:var(--h2LineHeightDesktop);--mobileLineHeightSize:\" id=\"\">Want to learn about the Phase 3 studies supporting approval of IDVYNSO?<\/h2><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:24px;--tablet-spacer:24px;--mobile-spacer:24px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<p class=\"has-regular-font-size\"><strong><a href=\"https:\/\/www.merckconnect.com\/idvynso\/trial-052-study-design\/\" aria-label=\"#\">Review Trial 052 data &gt;<\/a><\/strong><\/p>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:24px;--tablet-spacer:24px;--mobile-spacer:24px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<p class=\"has-regular-font-size\"><strong><a href=\"https:\/\/www.merckconnect.com\/idvynso\/trial-051-study-design\/\" aria-label=\"#\">Review Trial 051 data &gt;<\/a><\/strong><\/p>\n\n\n\n<p><\/p>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:40px;--tablet-spacer:40px;--mobile-spacer:40px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<div class=\"vivid360-heading\" id=\"ae65ca3cc-328b-451a-9bc3-9dcb87f34c60\"><h4 class=\"has-dark-text-color content-width fontWeightBold mt-0 mb-0\" style=\"--desktopFontSize:18px;--tabletFontSize:18px;--mobileFontSize:16px;--desktopLineHeightSize:27px;--tabletLineHeightSize:27px;--mobileLineHeightSize:\" id=\"\">Abbreviations<\/h4><\/div>\n\n\n\n<div style=\"background-color:transparent;height:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-16\"><\/div>\n\n\n\n<p class=\"has-dark-text-color has-text-color has-link-color has-regular-font-size wp-elements-76ac30901b220fbe05ee12e8400e5e96\">ART, antiretroviral therapy; ARV, antiretroviral; BMI, body mass index; INSTI, integrase strand transfer inhibitor; PLWH, person(s) living with HIV.<\/p>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:24px;--tablet-spacer:24px;--mobile-spacer:24px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Review Trial 052 data &gt; Review Trial 051 data &gt; ART, antiretroviral therapy; ARV, antiretroviral; BMI, body mass index; INSTI, integrase strand&#8230;<\/p>\n","protected":false},"author":4249,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_trash_the_other_posts":false,"editor_notices":[],"footnotes":""},"ga4_page_audience":[247],"ga4_page_birn_id":[],"ga4_page_branding":[264],"ga4_page_businessunit":[],"ga4_page_campaign":[],"ga4_page_content_purpose":[309],"ga4_page_customer_journey_stage":[341],"ga4_page_customer_specialty":[366],"ga4_page_experience":[],"ga4_page_indication":[471],"ga4_page_material_intent":[563],"ga4_page_product":[616],"ga4_page_region":[793],"ga4_page_therapeuticarea":[839],"user_role":[],"mhh-area-of-interest":[],"access":[],"user_status":[],"class_list":["post-547","page","type-page","status-publish"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - 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