{"id":592,"date":"2026-08-07T08:26:13","date_gmt":"2026-08-07T08:26:13","guid":{"rendered":"https:\/\/www.merckconnect.com\/idvynso\/?page_id=592"},"modified":"2026-08-20T08:47:40","modified_gmt":"2026-08-20T08:47:40","slug":"trial-052-ldl-c-and-non-hdl-c-data","status":"publish","type":"page","link":"https:\/\/www.merckconnect.com\/idvynso\/trial-052-ldl-c-and-non-hdl-c-data\/","title":{"rendered":"Trial 052 &#8211; LDL-C and non-HDL-C"},"content":{"rendered":"<link rel='stylesheet' id='vivid360-spacer-css-css' href='https:\/\/www.merckconnect.com\/idvynso\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/spacer\/css\/style.min.css?ver=1775653743' media='all' \/>\n\n<div style=\"background-color:transparent;--desktop-spacer:0px;--tablet-spacer:0px;--mobile-spacer:24px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n<link rel='stylesheet' id='vivid360-hero-css-css' href='https:\/\/www.merckconnect.com\/idvynso\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/hero\/css\/style.min.css?ver=1785934614' media='all' \/>\n\n<div id=\"\" class=\"wp-block-vivid360-hero\"><div class=\"vivid360-hero-container align-left align-middle ratio-70-30 horizontal desktop text-align-left is-overlay-style is-full-overlay is-opaque-overlay mobile-is-overlay-style mobile-is-full-overlay mobile-is-opaque-overlay mobile-uses-custom-styles\" style=\"border-width:0;border-style:solid;border-top-left-radius:0;border-top-right-radius:0;border-bottom-right-radius:0;border-bottom-left-radius:0;color:#092e49;--minHeight:218px;--mobileMinHeight:281px\"><div class=\"wide_screens hidden\" data-value=\"default\"><\/div><picture><source media=\"(max-width: 767px)\" srcset=\"https:\/\/www.merckconnect.com\/idvynso\/wp-content\/uploads\/sites\/338\/2026\/08\/Full-Overlay-mob-1.png?w=767\"\/><source media=\"(min-width: 768px) and (max-width:1024px)\" srcset=\"https:\/\/www.merckconnect.com\/idvynso\/wp-content\/uploads\/sites\/338\/2026\/08\/Full-Overlay-desk_d25180.png?w=1024\"\/><source media=\"(min-width: 1025px) and (max-width:1440px)\" srcset=\"https:\/\/www.merckconnect.com\/idvynso\/wp-content\/uploads\/sites\/338\/2026\/08\/Full-Overlay-desk_d25180.png?w=1440\"\/><img decoding=\"async\" width=\"1128\" height=\"218\" loading=\"lazy\" data-src=\"https:\/\/www.merckconnect.com\/idvynso\/wp-content\/uploads\/sites\/338\/2026\/08\/Full-Overlay-desk_d25180.png?w=1232\" src=\"https:\/\/www.merckconnect.com\/idvynso\/wp-content\/uploads\/sites\/338\/2026\/08\/Full-Overlay-desk_d25180.png?w=1232\" alt=\"\" class=\"hero-image\" style=\"--desktop-focal-x:50%;--desktop-focal-y:50%;--mobile-focal-x:50%;--mobile-focal-y:0%;--tablet-focal-x:50%;--tablet-focal-y:50%\"\/><\/picture><div class=\"hero-wrapper\"><div class=\"hero-content\"><h1 style=\"--headlineFontSize:36px;--headlineFontSizeTablet:36px;--headlineFontSizeMobile:20px;--headlineLineHeight:45px;--headlineLineHeightTablet:45px;--headlineLineHeightMobile:30px\" class=\"hero-title fontWeightBold\">Trial 052: LDL-C and non-HDL-C data for IDVYNSO<sup>TM<\/sup> (doravirine\/islatravir) and <em>Biktarvy<\/em>\u00ae through week 48<\/h1><p class=\"hero-description\"><\/p><div class=\"hero-btn-group\"><\/div><div class=\"hero-caption\"><\/div><\/div><\/div><\/div><div class=\"hero-caption-2desktop\"><\/div><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:16px;--tablet-spacer:16px;--mobile-spacer:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<p class=\"has-medium-font-size\"><strong>Limitations:<\/strong><\/p>\n\n\n<link rel='stylesheet' id='vivid360-list-css-css' href='https:\/\/www.merckconnect.com\/idvynso\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/list\/css\/style.min.css?ver=1775653743' media='all' \/>\n\n<div class=\"vivid-block-list content-width  default-list block-0cc476fc-6c08-467b-b569-09f3a74c1b4f\" data-image=\"\" data-image-mobile=\"\" data-image-all=\"\" data-image-all-mobile=\"\" data-icon-color=\"#333\" data-text-color=\"#333\" data-client-id=\"block-0cc476fc-6c08-467b-b569-09f3a74c1b4f\"><ul class=\"first-level\"><li>Participants on lipid-lowering therapy were excluded.<\/li><li>For those who initiated lipid-lowering therapy during the study, only measurements collected before the initiation of lipid-lowering therapy were included in the analysis.<\/li><li>This was an exploratory analysis with no hypothesis and no multiplicity control.<\/li><\/ul><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:16px;--tablet-spacer:16px;--mobile-spacer:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<p class=\"has-medium-font-size\"><strong>The clinical benefits of these findings have not been demonstrated.<\/strong><\/p>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:32px;--tablet-spacer:32px;--mobile-spacer:32px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<div class=\"wp-block-columns mb-0 is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:10%\"><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:80%\"><link rel='stylesheet' id='vivid360-heading-css-css' href='https:\/\/www.merckconnect.com\/idvynso\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/heading\/css\/style.min.css?ver=1775653743' media='all' \/>\n\n<div class=\"vivid360-heading\" id=\"a5bc3abb2-e93e-4056-8545-266cd57ded41\"><h3 class=\"has-text-align-center content-width fontWeightRegular\" style=\"--desktopFontSize:20px;--tabletFontSize:20px;--mobileFontSize:20px;--desktopLineHeightSize:30px;--tabletLineHeightSize:30px;--mobileLineHeightSize:;--tabletAlign:center;--mobileAlign:center\" id=\"\"><strong>Mean Change From Baseline in Fasting LDL-C and Non-HDL-C Through Week 48 in Trial 052 \u2028in Participants Who Were Not on Lipid-Lowering Agents<sup>1<\/sup><\/strong><\/h3><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:10%\"><\/div>\n<\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:16px;--tablet-spacer:16px;--mobile-spacer:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<figure class=\"wp-block-flexible-table-block-table is-content-justification-left is-scroll-on-pc is-scroll-on-mobile\"><table class=\"has-fixed-layout\"><thead><tr><th style=\"background-color:#e4e4e4;width:390px;border-style:solid;border-width:1px;border-color:#c4c4c4\"><\/th><th style=\"background-color:#c01cd9;width:70px;color:#FFF;text-align:center;border-style:solid;border-width:1px;border-color:#c4c4c4\">n<\/th><th style=\"background-color:#c01cd9;width:191px;color:#FFF;text-align:center;border-style:solid;border-width:1px;border-color:#c4c4c4\">IDVYNSO<sup>a<\/sup><\/th><th style=\"background-color:#555;width:69px;color:#FFF;text-align:center;border-style:solid;border-width:1px;border-color:#c4c4c4\">n<\/th><th style=\"background-color:#555;color:#FFF;text-align:center;width:191px;border-style:solid;border-width:1px;border-color:#c4c4c4\">BIC\/FTC\/TAF<sup>a<\/sup><\/th><th style=\"background-color:#092e49;color:#FFF;text-align:center;width:191px;border-style:solid;border-width:1px;border-color:#c4c4c4\"><strong>Difference (95% CI)<sup>b<\/sup><\/strong><\/th><\/tr><\/thead><tbody><tr><td colspan=\"6\" style=\"font-size:16px;background-color:#f4f4f4;width:390px;border-style:solid;border-width:1px;border-color:#c4c4c4\">Fasting LDL-C<\/td><\/tr><tr><td style=\"font-size:16px;width:390px;border-width:1px;border-color:#c4c4c4\">Baseline, mg\/dL<\/td><td style=\"width:70px;font-size:16px;text-align:center;border-width:1px;border-color:#c4c4c4\"><strong>252<\/strong><\/td><td style=\"width:191px;font-size:16px;text-align:center;border-width:1px;border-color:#c4c4c4\">107.83<\/td><td style=\"font-size:16px;width:69px;text-align:center;border-width:1px;border-color:#c4c4c4\"><strong>117<\/strong><\/td><td style=\"width:191px;font-size:16px;text-align:center;border-width:1px;border-color:#c4c4c4\">109.43<\/td><td style=\"width:191px;font-size:16px;text-align:center;border-width:1px;border-color:#c4c4c4\">&#8211;<\/td><\/tr><tr><td style=\"font-size:16px;width:390px;border-color:#c4c4c4;border-width:1px\">Week 48 change from baseline (95% CI)<\/td><td style=\"width:70px;font-size:16px;text-align:center;border-color:#c4c4c4;border-width:1px\"><strong>222<\/strong><\/td><td style=\"width:191px;font-size:16px;text-align:center;border-color:#c4c4c4;border-width:1px\">0.99 (-1.96, 3.95)<\/td><td style=\"font-size:16px;width:69px;text-align:center;border-color:#c4c4c4;border-width:1px\"><strong>102<\/strong><\/td><td style=\"width:191px;font-size:16px;text-align:center;border-color:#c4c4c4;border-width:1px\">2.55 (-1.65, 6.75)<\/td><td style=\"width:191px;font-size:16px;text-align:center;border-color:#c4c4c4;border-width:1px\">-1.53 (-6.51, 3.44)<\/td><\/tr><tr><td colspan=\"6\" style=\"font-size:16px;background-color:#f4f4f4;width:390px;border-width:1px;border-color:#c4c4c4\">Fasting Non-HDL-C<\/td><\/tr><tr><td style=\"font-size:16px;width:390px;border-color:#c4c4c4;border-width:1px\">Baseline, mg\/dL<\/td><td style=\"width:70px;font-size:16px;text-align:center;border-color:#c4c4c4;border-width:1px\"><strong>252<\/strong><\/td><td style=\"width:191px;font-size:16px;text-align:center;border-color:#c4c4c4;border-width:1px\">130.20<\/td><td style=\"font-size:16px;width:69px;text-align:center;border-color:#c4c4c4;border-width:1px\"><strong>117<\/strong><\/td><td style=\"width:191px;font-size:16px;text-align:center;border-color:#c4c4c4;border-width:1px\">133.03<\/td><td style=\"width:191px;font-size:16px;text-align:center;border-color:#c4c4c4;border-width:1px\">&#8211;<\/td><\/tr><tr><td style=\"font-size:16px;width:390px;border-color:#c4c4c4;border-width:1px\">Week 48 change from baseline (95% CI)<\/td><td style=\"width:70px;font-size:16px;text-align:center;border-color:#c4c4c4;border-width:1px\"><strong>222<\/strong><\/td><td style=\"width:191px;font-size:16px;text-align:center;border-color:#c4c4c4;border-width:1px\">0.20 (-2.90, 3.29)<\/td><td style=\"font-size:16px;width:69px;text-align:center;border-color:#c4c4c4;border-width:1px\"><strong>103<\/strong><\/td><td style=\"width:191px;font-size:16px;text-align:center;border-color:#c4c4c4;border-width:1px\">1.08 (-3.21, 5.37)<\/td><td style=\"width:191px;font-size:16px;text-align:center;border-color:#c4c4c4;border-width:1px\">-1.23 (-6.43, 3.97)<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"has-small-font-size\"><sup>a<\/sup>Within-group 95% confidence intervals were based on the t-distribution.<\/p>\n\n\n\n<p class=\"has-small-font-size\"><sup>b<\/sup>The 95% confidence intervals for the treatment difference were calculated from ANCOVA models with terms for baseline measurement and treatment.<\/p>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:16px;--tablet-spacer:16px;--mobile-spacer:18px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n<link rel='stylesheet' id='vivid360-separator-css-css' href='https:\/\/www.merckconnect.com\/idvynso\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/separator\/css\/style.min.css?ver=1775653743' media='all' \/>\n\n<hr class=\"wp-block-vivid360-separator has-text-color has-background has-primary-background-color has-primary-color desktopwidth mobileWidth\" style=\"height:0;--desktopwidth:66%;--mobileWidth:100%\"\/>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:16px;--tablet-spacer:16px;--mobile-spacer:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<div class=\"vivid360-heading default-hcp-tablet-fontsize\" id=\"aa6ca331e-ecaa-45fa-b700-0a2904902369\"><h2 class=\"has-dark-text-color content-width fontWeightBold mt-0 mb-0\" style=\"--desktopFontSize:24px;--tabletFontSize:var(--h2FontSizeDesktop);--mobileFontSize:20px;--desktopLineHeightSize:36px;--tabletLineHeightSize:var(--h2LineHeightDesktop);--mobileLineHeightSize:\" id=\"\">Continue exploring Trial 052<\/h2><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:24px;--tablet-spacer:24px;--mobile-spacer:24px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<p class=\"has-regular-font-size\"><a href=\"https:\/\/www.merckconnect.com\/idvynso\/trial-052-study-design\/\" aria-label=\"#\"><strong>Review clinical trial data here &gt;<\/strong><\/a><\/p>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:24px;--tablet-spacer:24px;--mobile-spacer:24px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<div class=\"vivid360-heading default-hcp-tablet-fontsize\" id=\"a2b94c48c-719c-4cae-9b0e-a3c1e9ca840b\"><h2 class=\"has-dark-text-color content-width fontWeightBold mt-0 mb-0\" style=\"--desktopFontSize:24px;--tabletFontSize:var(--h2FontSizeDesktop);--mobileFontSize:20px;--desktopLineHeightSize:36px;--tabletLineHeightSize:var(--h2LineHeightDesktop);--mobileLineHeightSize:\" id=\"\">Considering a change in antiretroviral (ARV) regimen for the individuals you are treating?<\/h2><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:24px;--tablet-spacer:24px;--mobile-spacer:24px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<p class=\"has-regular-font-size\"><strong><a href=\"https:\/\/www.merckconnect.com\/idvynso\/plwh-profile-1\/\" aria-label=\"#\">Walk through a PLWH clinical scenario &gt;<\/a><\/strong><\/p>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:40px;--tablet-spacer:40px;--mobile-spacer:40px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<div class=\"vivid360-heading\" id=\"a056b092c-732c-417b-9552-8351ea024c42\"><h4 class=\"has-dark-text-color content-width fontWeightBold\" style=\"--desktopFontSize:18px;--tabletFontSize:18px;--mobileFontSize:16px;--desktopLineHeightSize:27px;--tabletLineHeightSize:27px;--mobileLineHeightSize:\" id=\"\"><strong>Abbreviations<\/strong><\/h4><\/div>\n\n\n\n<div style=\"background-color:transparent;height:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-16\"><\/div>\n\n\n\n<p class=\"has-dark-text-color has-text-color has-link-color has-regular-font-size wp-elements-a7239a70a67f48e3a4629a9dd6fb5634\">ANCOVA, analysis of covariance; BIC, bictegravir; FTC, emtricitabine; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; TAF, tenofovir alafenamide.<\/p>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:16px;--tablet-spacer:16px;--mobile-spacer:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<div class=\"vivid360-heading\" id=\"a5ee6f21f-78a2-4a1a-b2f8-9ec7278c63c8\"><h4 class=\"has-dark-text-color content-width fontWeightRegular\" style=\"--desktopFontSize:18px;--tabletFontSize:18px;--mobileFontSize:16px;--desktopLineHeightSize:27px;--tabletLineHeightSize:27px;--mobileLineHeightSize:\" id=\"\"><strong>Reference<\/strong><\/h4><\/div>\n\n\n\n<div style=\"background-color:transparent;height:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-8\"><\/div>\n\n\n<link rel='stylesheet' id='vivid360-list-parent-css-css' href='https:\/\/www.merckconnect.com\/idvynso\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/list-parent\/css\/style.css?ver=1775653743' media='all' \/>\n\n<div class=\"vivid-block-list2 content-width isBold \">\n<ol style=\"--listBulletColor:#333\" class=\"list-bullet-color has-dark-text-color has-text-color has-link-color wp-elements-dee40d00de347914683b4e56dedebc70\">\n<li class=\"has-regular-font-size\">Colson AE, Mills AM, Ramgopal MN, et al. Switch to fixed-dose doravirine (100 mg) and islatravir (0.25 mg) once daily in virologically suppressed adults with HIV-1 on bictegravir, emtricitabine, and tenofovir alafenamide: 48-week results of a phase 3, multicentre, randomised, controlled, double-blind, non-inferiority trial. <em>Lancet<\/em>. 2026;407(10528)(suppl):611-621.<\/li>\n<\/ol>\n<\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:16px;--tablet-spacer:16px;--mobile-spacer:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Limitations: The clinical benefits of these findings have not been demonstrated. aWithin-group 95% confidence intervals were based on the t-distribution. bThe 95%&#8230;<\/p>\n","protected":false},"author":4249,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_trash_the_other_posts":false,"editor_notices":[],"footnotes":""},"ga4_page_audience":[247],"ga4_page_birn_id":[],"ga4_page_branding":[264],"ga4_page_businessunit":[],"ga4_page_campaign":[],"ga4_page_content_purpose":[292],"ga4_page_customer_journey_stage":[341],"ga4_page_customer_specialty":[366],"ga4_page_experience":[],"ga4_page_indication":[471],"ga4_page_material_intent":[563],"ga4_page_product":[616],"ga4_page_region":[793],"ga4_page_therapeuticarea":[839],"user_role":[],"mhh-area-of-interest":[],"access":[],"user_status":[],"class_list":["post-592","page","type-page","status-publish"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Trial 052 LDL-C and Non-HDL-C Data for IDVYNSO\u2122 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