{"id":56,"date":"2026-04-08T09:23:56","date_gmt":"2026-04-08T09:23:56","guid":{"rendered":"https:\/\/www.merckconnect.com\/ohtuvayre\/?page_id=56"},"modified":"2026-08-21T20:31:40","modified_gmt":"2026-08-21T20:31:40","slug":"mechanism-of-action","status":"publish","type":"page","link":"https:\/\/www.merckconnect.com\/ohtuvayre\/mechanism-of-action\/","title":{"rendered":"Mechanism of action"},"content":{"rendered":"\n\n
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A novel mechanism of action in COPD1,2<\/sup><\/h1>

OHTUVAYRE\u00ae (ensifentrine) is a non-corticosteroid treatment that can be prescribed by itself or as an add-on to maintenance treatment.2<\/sup><\/p>

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PDE3 and PDE4 enzymes are present throughout the body, including various cells of the lungs.3<\/sup><\/h3><\/div>\n\n\n\n
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Smooth muscle cells<\/em><\/p>\n<\/div>\n\n\n\n

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Immune cells<\/em><\/p>\n<\/div>\n<\/div>\n\n\n\n

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PDE3 and PDE4<\/mark><\/h4>
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Impact secondary messengers involved with signaling in the lungs.3<\/sup><\/p><\/div><\/div>\n\n\n\n

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