{"id":58,"date":"2026-04-08T09:24:33","date_gmt":"2026-04-08T09:24:33","guid":{"rendered":"https:\/\/www.merckconnect.com\/ohtuvayre\/?page_id=58"},"modified":"2026-08-21T19:00:15","modified_gmt":"2026-08-21T19:00:15","slug":"dosage-and-administration","status":"publish","type":"page","link":"https:\/\/www.merckconnect.com\/ohtuvayre\/dosage-and-administration\/","title":{"rendered":"Dosage and administration"},"content":{"rendered":"\n\n
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Dosage and administration for OHTUVAYRE\u00ae<\/sup> (ensifentrine)<\/h1>

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A COPD treatment using a standard jet nebulizer1<\/sup><\/h3><\/div>\n\n\n\n
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The recommended dosage of OHTUVAYRE is 3 mg (one unit-dose ampule) twice daily, once in the morning and once in the evening, administered by oral inhalation using a standard jet nebulizer with a mouthpiece. Each treatment session takes 5-7 minutes per dose.<\/p><\/div><\/div>\n<\/div><\/div><\/div><\/div>\n\n\n\n

COPD, chronic obstructive pulmonary disease.<\/p>\n\n\n\n

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\"OHTUVAYRE\u00ae\"OHTUVAYRE\u00ae
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Ready to learn more<\/mark> about OHTUVAYRE?<\/h2>

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Clinical data & efficacy<\/span><\/a><\/div>\n<\/div>
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References<\/h3><\/div>\n\n\n\n
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  1. Anzueto A, Barjaktarevic IZ, Siler TM, et al. Ensifentrine, a novel phosphodiesterase 3 and 4 inhibitor for the treatment of chronic obstructive pulmonary disease: randomized, double-blind, placebo-controlled, multicenter phase III trials (the ENHANCE trials). Am J Respir Crit Care Med<\/em>. 2023;208(4):406-416. doi:10.1164\/rccm.202306-0944OC<\/li>\n<\/ol>\n<\/div>\n\n\n\n
    <\/div>\n","protected":false},"excerpt":{"rendered":"

    COPD, chronic obstructive pulmonary disease.<\/p>\n","protected":false},"author":605,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_trash_the_other_posts":false,"editor_notices":[],"footnotes":""},"ga4_page_audience":[8],"ga4_page_birn_id":[],"ga4_page_branding":[25],"ga4_page_businessunit":[30],"ga4_page_campaign":[],"ga4_page_content_purpose":[47],"ga4_page_customer_journey_stage":[102],"ga4_page_customer_specialty":[163],"ga4_page_experience":[],"ga4_page_indication":[324],"ga4_page_material_intent":[364],"ga4_page_product":[],"ga4_page_region":[747],"ga4_page_therapeuticarea":[814],"user_role":[],"mhh-area-of-interest":[],"access":[],"user_status":[],"class_list":["post-58","page","type-page","status-publish"],"yoast_head":"\nRecommended Dosage for OHTUVAYRE\u00ae (ensifentrine)<\/title>\n<meta name=\"description\" content=\"Review the dosing and administration information for 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