Adjuvant treatment for breast cancer
Administer according to 1 of the following doses and schedules for a total of 52 weeks of ONTRUZANT breast cancer therapy:
During and following paclitaxel, docetaxel, or docetaxel and carboplatin:

Initial ONTRUZANT dose of 4 mg/kg as an intravenous infusion over 90 minutes, then 2 mg/kg as an intravenous infusion over 30 minutes weekly during chemotherapy for the first 12 weeks (paclitaxel or docetaxel) or for 18 weeks (docetaxel and carboplatin).

One week following the last weekly dose of ONTRUZANT, administer ONTRUZANT 6 mg/kg as an intravenous infusion over 30 to 90 minutes every 3 weeks.
As a single agent within 3 weeks following completion of multi-modality, anthracycline based chemotherapy regimens:

Initial dose at 8 mg/kg as an intravenous infusion over 90 minutes.

Subsequent doses at 6 mg/kg as an intravenous infusion over 30 to 90 minutes every 3 weeks.

Extending adjuvant treatment beyond 1 year is not recommended.
Treatment for metastatic breast cancer

Administer ONTRUZANT, alone or in combination with paclitaxel, at an initial once-weekly dose of 4 mg/kg as a 90-minute intravenous infusion followed by subsequent once-weekly doses of 2 mg/kg as 30-minute intravenous infusions until disease progression.
How Supplied
420 mg Multiple-dose vial | Carton of 1 multiple-dose vial of ONTRUZANT and 1 vial (20 mL) of Bacteriostatic Water for Injection (BWFI), USP, containing 1.1% benzyl alcohol as a preservative | NDC 0006-5034-02 |
150 mg Single-dose vial | Carton of 1 single-dose vial as a white to pale yellow lyophilized sterile powder, under vacuum | NDC 0006-5033-02 |
For more information on ONTRUZANT, please contact us at 1-877-888-4231.
Important dosing considerations
- If the patient has missed a dose of ONTRUZANT by 1 week or less, then the usual maintenance dose (weekly schedule: 2 mg/kg; 3-weekly schedule: 6 mg/kg) should be administered as soon as possible. Do not wait until the next planned cycle. Subsequent ONTRUZANT maintenance doses should be administered 7 days or 21 days later according to the weekly or 3-weekly schedules, respectively.
- If the patient has missed a dose of ONTRUZANT by more than 1 week, a re-loading dose of ONTRUZANT should be administered over approximately 90 minutes (weekly schedule: 4 mg/kg; 3-weekly schedule: 8 mg/kg) as soon as possible. Subsequent ONTRUZANT maintenance doses (weekly schedule: 2 mg/kg; 3-weekly schedule: 6 mg/kg) should be administered 7 days or 21 days later according to the weekly or 3-weekly schedules, respectively.