{"id":1925,"date":"2024-03-14T11:01:51","date_gmt":"2024-03-14T11:01:51","guid":{"rendered":"https:\/\/www.merckconnect.com\/prevymis\/?page_id=1925"},"modified":"2026-03-30T10:41:18","modified_gmt":"2026-03-30T10:41:18","slug":"cmv-in-kidney-transplant-patients","status":"publish","type":"page","link":"https:\/\/www.merckconnect.com\/prevymis\/cmv-in-kidney-transplant-patients\/","title":{"rendered":"CMV in kidney transplant"},"content":{"rendered":"\n<p><\/p>\n\n\n<link rel='stylesheet' id='vivid360-spacer-css-css' href='https:\/\/www.merckconnect.com\/prevymis\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/spacer\/css\/style.min.css?ver=1765194012' media='all' \/>\n\n<div style=\"background-color:transparent;height:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-8\"><\/div>\n\n\n<link rel='stylesheet' id='vivid360-heading-css-css' href='https:\/\/www.merckconnect.com\/prevymis\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/heading\/css\/style.min.css?ver=1765194012' media='all' \/>\n\n<div class=\"vivid360-heading default-hcp-fontsize default-hcp-tablet-fontsize default-hcp-mobile-fontsize\" id=\"af1a37cde-4e5e-4afb-b595-5794a0b6a985\"><h1 class=\"content-width fontWeightRegular\" style=\"--desktopFontSize:var(--h1FontSizeDesktop);--tabletFontSize:var(--h1FontSizeDesktop);--mobileFontSize:var(--h1FontSizeMobile);--desktopLineHeightSize:var(--h1LineHeightDesktop);--tabletLineHeightSize:var(--h1LineHeightDesktop);--mobileLineHeightSize:\" id=\"top\"><strong>Background of CMV infection in kidney transplant<\/strong><\/h1><\/div>\n\n\n\n<div style=\"background-color:transparent;height:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-8\"><\/div>\n\n\n\n<div class=\"vivid360-heading default-hcp-fontsize default-hcp-tablet-fontsize default-hcp-mobile-fontsize\" id=\"a2a0e0743-25b9-4869-a279-191334c056e9\"><h2 class=\"content-width fontWeightRegular\" style=\"--desktopFontSize:var(--h2FontSizeDesktop);--tabletFontSize:var(--h2FontSizeDesktop);--mobileFontSize:var(--h2FontSizeMobile);--desktopLineHeightSize:var(--h2LineHeightDesktop);--tabletLineHeightSize:var(--h2LineHeightDesktop);--mobileLineHeightSize:\" id=\"\"><strong>D+\/R- CMV serostatus puts your kidney transplant recipients at highest risk<sup>1,2<\/sup><\/strong><\/h2><\/div>\n\n\n\n<div style=\"background-color:transparent;height:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-8\"><\/div>\n\n\n\n<p><strong>Cytomegalovirus is an important cause of morbidity and mortality after kidney transplant<sup>1,3<\/sup><\/strong><\/p>\n\n\n\n<p>Numerous complexities surround the management of patients post-kidney transplant, including managing the risk of CMV.<sup>1,4<\/sup><\/p>\n\n\n\n<div style=\"background-color:transparent;height:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-8\"><\/div>\n\n\n\n<div class=\"vivid360-heading\" id=\"acf739711-769c-4562-87c6-38337f13b86f\"><h3 class=\"content-width fontWeightRegular\" style=\"--desktopFontSize:var(--h3FontSizeDesktop);--tabletFontSize:var(--h3FontSizeDesktop);--mobileFontSize:var(--h3FontSizeMobile);--desktopLineHeightSize:var(--h3LineHeightDesktop);--tabletLineHeightSize:var(--h3LineHeightDesktop);--mobileLineHeightSize:\" id=\"\"><strong>Without a prevention strategy, CMV infection and disease can occur after transplant<sup>1,5<\/sup><\/strong><\/h3><\/div>\n\n\n\n<p>CMV has been associated with increased risk of other infectious complications such as:<sup>1,5<\/sup><\/p>\n\n\n<link rel='stylesheet' id='vivid360-list-css-css' href='https:\/\/www.merckconnect.com\/prevymis\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/list\/css\/style.min.css?ver=1765194012' media='all' \/>\n\n<div class=\"vivid-block-list content-width  default-list block-7d3b9655-09d2-4198-bdf8-522b9f44682f\" data-image=\"\" data-image-mobile=\"\" data-image-all=\"\" data-image-all-mobile=\"\" data-icon-color=\"#333\" data-text-color=\"#333\" data-client-id=\"block-7d3b9655-09d2-4198-bdf8-522b9f44682f\"><ul class=\"first-level\"><li>Bacteremia<\/li><li>Invasive fungal diseases<\/li><li>Epstein\u2010Barr virus\u2010mediated post\u2010transplant lymphoproliferative disorders<\/li><\/ul><\/div>\n\n\n\n<div style=\"background-color:transparent;height:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-8\"><\/div>\n\n\n\n<p>CMV infection is also associated with acute rejection and chronic allograft injury.<sup>1,5,6<\/sup><\/p>\n\n\n\n<div style=\"background-color:transparent;height:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-8\"><\/div>\n\n\n\n<div class=\"vivid360-heading default-hcp-fontsize default-hcp-tablet-fontsize default-hcp-mobile-fontsize\" id=\"aa275f936-7628-4990-a0c8-4802c0274f65\"><h2 class=\"content-width fontWeightRegular\" style=\"--desktopFontSize:var(--h2FontSizeDesktop);--tabletFontSize:var(--h2FontSizeDesktop);--mobileFontSize:var(--h2FontSizeMobile);--desktopLineHeightSize:var(--h2LineHeightDesktop);--tabletLineHeightSize:var(--h2LineHeightDesktop);--mobileLineHeightSize:\" id=\"\"><strong>D+\/R- kidney transplant recipients are at highest risk for CMV disease and the associated complications<sup>1<\/sup><br><\/strong><\/h2><\/div>\n\n\n\n<div style=\"background-color:transparent;height:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-8\"><\/div>\n\n\n\n<p><strong>In addition to serostatus, another risk factor for CMV infection and disease post-kidney transplant is drug-induced immunosuppression<sup>1,3,5,7<\/sup><\/strong><\/p>\n\n\n\n<div style=\"background-color:transparent;height:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-8\"><\/div>\n\n\n<link rel='stylesheet' id='vivid360-quote-css-css' href='https:\/\/www.merckconnect.com\/prevymis\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/quote\/css\/style.min.css?ver=1765194012' media='all' \/>\n\n<div id=\"\" class=\"wp-block-vivid360-quote has-text-align-left has-vertical-bar\"><blockquote><p class=\"quote-content\"><span class=\"vertical-bar\"><\/span><span class=\"h2 fontWeightRegular\"><strong>CMV infection post-kidney transplant is associated with increased morbidity, including acute rejection and chronic allograft injury<sup>1,3,5,6<\/sup><\/strong><\/span><\/p><\/blockquote><\/div>\n\n\n\n<div style=\"background-color:transparent;height:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-16\"><\/div>\n\n\n\n<div class=\"vivid360-heading\" id=\"abc9d10f6-fa6a-46e0-98c0-95ee3f426a4d\"><h4 class=\"content-width fontWeightRegular\" style=\"--desktopFontSize:var(--h4FontSizeDesktop);--tabletFontSize:var(--h4FontSizeDesktop);--mobileFontSize:var(--h4FontSizeMobile);--desktopLineHeightSize:var(--h4LineHeightDesktop);--tabletLineHeightSize:var(--h4LineHeightDesktop);--mobileLineHeightSize:\" id=\"\">References<\/h4><\/div>\n\n\n\n<div class=\"vivid-block-list content-width  block-da3bbe4f-442b-4e8c-bfa6-febf057de4d0\" data-image=\"\" data-image-mobile=\"\" data-image-all=\"\" data-image-all-mobile=\"\" data-icon-color=\"#333\" data-text-color=\"#333\" data-client-id=\"block-da3bbe4f-442b-4e8c-bfa6-febf057de4d0\"><ol class=\"first-level default-order\"><li>Razonable RR, Humar A. Cytomegalovirus in solid organ transplant recipients\u2014guidelines of the American Society of Transplantation Infectious Diseases Community of Practice. <em>Clin Transplant.<\/em> 2019;33(9):e13512. doi:10.1111\/ctr.13512<\/li><li>Valencia Deray KG, Hosek KE, Chilukuri D, et al. Epidemiology and long-term outcomes of cytomegalovirus DNAemia and disease in pediatric solid organ transplant recipients. <em>Am J Transplant<\/em>. 2022;(1 ):187-198. doi :10.1111 \/ajt.16822<\/li><li>Ashoor IF, Solomon S. Post-transplant recipient infectious challenges. In: Alpay S, Benitz AP, Sener EO, eds.<em> Challenges in Pediatric Kidney Transplantation.<\/em> Springer; 2020:145-176. doi:10.1007\/978-3-030-74783-1<\/li><li>National Kidney Foundation (NKF). <em>Managing Kidney Transplant Recipients.<\/em> National Kidney Foundation; 2011. June 9, 2025. <span><span class=\"word-break\">Https:\/\/www.kidney.org\/sites\/<span class=\"no-wrap-text\">default\/files\/02-50-4080_ABB_<\/span>ManagingTransRecipBk_Neph.pdf<\/span><\/span><\/li><li>Smith JM, Kizilbash SJ, Dharnidharka VR. Prevention and treatment of infectious complications in pediatric renal transplant recipients. In: Schaefer F, Greenbaum LA, eds. <em>Pediatric Kidney Disease.<\/em> Springer; 2023. doi:10.1007\/978-3-031-11665-0_69<\/li><li>Harambat J, Madden I. Initiation of kidney replacement therapy: strategic choices and preparation. In: Schaefer F, Greenbaum LA, eds. <em>Pediatric Kidney Disease.<\/em> Springer; 2023. doi:10.1007\/978-3-031-11665-0_64<\/li><li>T\u00f6nshoff B, Melk A, H\u00f6cker B. Immunosuppression in pediatric kidney transplantation. In: Schaefer F, Greenbaum LA, eds.<em> Pediatric Kidney Disease.<\/em> Springer; 2023. doi:10.1007\/978-3-031-11665-0_67<\/li><\/ol><\/div>\n\n\n\n<div style=\"background-color:transparent;height:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-16\"><\/div>\n\n\n\n<p><a href=\"#top\" aria-label=\"#\">Back to top<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cytomegalovirus is an important cause of morbidity and mortality after kidney transplant1,3 Numerous complexities surround the management of patients post-kidney transplant, including&#8230;<\/p>\n","protected":false},"author":699,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_trash_the_other_posts":false,"editor_notices":[],"footnotes":""},"ga4_page_audience":[],"ga4_page_birn_id":[],"ga4_page_branding":[270],"ga4_page_businessunit":[],"ga4_page_campaign":[],"ga4_page_content_purpose":[284],"ga4_page_customer_journey_stage":[336],"ga4_page_customer_specialty":[361],"ga4_page_experience":[],"ga4_page_indication":[],"ga4_page_material_intent":[576],"ga4_page_product":[599],"ga4_page_region":[910],"ga4_page_therapeuticarea":[],"user_role":[],"mhh-area-of-interest":[],"access":[],"user_status":[],"class_list":["post-1925","page","type-page","status-publish"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Background of CMV Infection in Kidney Transplant 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