{"id":74,"date":"2023-03-24T12:48:03","date_gmt":"2023-03-24T12:48:03","guid":{"rendered":"https:\/\/www.merckconnect.com\/prevymis\/?page_id=74"},"modified":"2026-04-28T12:41:11","modified_gmt":"2026-04-28T12:41:11","slug":"astct-guidelines","status":"publish","type":"page","link":"https:\/\/www.merckconnect.com\/prevymis\/astct-guidelines\/","title":{"rendered":"Professional Resources: American Society for Transplantation and Cellular Therapy (ASTCT) Practice Guidelines"},"content":{"rendered":"<link rel='stylesheet' id='vivid360-spacer-css-css' href='https:\/\/www.merckconnect.com\/prevymis\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/spacer\/css\/style.min.css?ver=1765194012' media='all' \/>\n\n<div style=\"background-color:transparent;height:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-8 spacer-undefined\"><\/div>\n\n\n<link rel='stylesheet' id='vivid360-heading-css-css' href='https:\/\/www.merckconnect.com\/prevymis\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/heading\/css\/style.min.css?ver=1765194012' media='all' \/>\n\n<div class=\"vivid360-heading default-hcp-fontsize default-hcp-tablet-fontsize default-hcp-mobile-fontsize\" id=\"a04394b96-6442-4883-ac52-77bf4b0f3455\"><h1 class=\"content-width fontWeightRegular\" style=\"--desktopFontSize:var(--h1FontSizeDesktop);--tabletFontSize:var(--h1FontSizeDesktop);--mobileFontSize:var(--h1FontSizeMobile);--desktopLineHeightSize:var(--h1LineHeightDesktop);--tabletLineHeightSize:var(--h1LineHeightDesktop);--mobileLineHeightSize:\" id=\"top\"><strong>American Society for Transplantation and Cellular Therapy (ASTCT) practice guidelines<\/strong><\/h1><\/div>\n\n\n\n<div style=\"background-color:transparent;height:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-16\"><\/div>\n\n\n\n<div class=\"vivid360-heading default-hcp-fontsize default-hcp-tablet-fontsize default-hcp-mobile-fontsize\" id=\"a3d386ecd-7bc0-4d5e-b5e0-1b854bfb42a3\"><h2 class=\"content-width fontWeightRegular\" style=\"--desktopFontSize:var(--h2FontSizeDesktop);--tabletFontSize:var(--h2FontSizeDesktop);--mobileFontSize:var(--h2FontSizeMobile);--desktopLineHeightSize:var(--h2LineHeightDesktop);--tabletLineHeightSize:var(--h2LineHeightDesktop);--mobileLineHeightSize:\" id=\"\">The American Society for Transplantation and Cellular Therapy (ASTCT) practice guidelines recommend PREVYMIS\u00ae (letermovir) for CMV R+ allogeneic HSCT recipients<sup>1,2<\/sup><\/h2><\/div>\n\n\n\n<div style=\"background-color:transparent;height:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-16\"><\/div>\n\n\n\n<div class=\"paragraph-wrapper wp-elements-868cbcc2896fd7bad4030827379bc175\"><div class=\"_df2315ac-f38c-4842-8502-5cc2f4155f72 \" id=\"\"><p class=\"has-primary-color has-text-color has-link-color\" style=\"font-size:18px\"><strong>2021 ASTCT Guideline Excerpts<\/strong><\/p><\/div><\/div>\n\n\n\n<div style=\"background-color:transparent;height:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-8\"><\/div>\n\n\n\n<p><strong>PREVYMIS\u00ae (letermovir) primary prophylaxis is recommended for adult CMV R+ allogeneic HSCT recipients to begin no later than 28 days after HSCT and continuing through Day 100 (A-I)<sup>1<\/sup>:<\/strong><\/p>\n\n\n\n<div style=\"background-color:transparent;height:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-8\"><\/div>\n\n\n<link rel='stylesheet' id='vivid360-list-css-css' href='https:\/\/www.merckconnect.com\/prevymis\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/list\/css\/style.min.css?ver=1765194012' media='all' \/>\n\n<div class=\"vivid-block-list content-width  default-list block-b61ee9f7-8301-475c-81ea-bb9ab9b260bd\" data-image=\"\" data-image-mobile=\"\" data-image-all=\"\" data-image-all-mobile=\"\" data-icon-color=\"#333\" data-text-color=\"#333\" data-client-id=\"block-b61ee9f7-8301-475c-81ea-bb9ab9b260bd\"><ul class=\"first-level\"><li>PREVYMIS has received an A-I recommendation<sup>a<\/sup> for adult patients<\/li><\/ul><\/div>\n\n\n\n<div style=\"background-color:transparent;height:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-8\"><\/div>\n\n\n\n<div class=\"paragraph-wrapper wp-elements-b06a4237ede75b434abc42dde22f5603\"><div class=\"_02a125b0-2249-4596-85d1-d5c2b26e62f8 \" id=\"\"><p class=\"has-primary-color has-text-color has-link-color\" style=\"font-size:18px\"><strong>2025 ASTCT Guideline Excerpts<\/strong><\/p><\/div><\/div>\n\n\n\n<div style=\"background-color:transparent;height:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-8\"><\/div>\n\n\n\n<p><strong>Extending PREVYMIS\u00ae (letermovir) primary prophylaxis through Day 200 is recommended for high-risk HSCT recipients (B-I)<sup>2<\/sup>:<\/strong><\/p>\n\n\n\n<div style=\"background-color:transparent;height:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-8\"><\/div>\n\n\n\n<div class=\"vivid-block-list content-width  default-list block-6e1d189b-ca6b-403a-b5ab-26e4c8c81431\" data-image=\"\" data-image-mobile=\"\" data-image-all=\"\" data-image-all-mobile=\"\" data-icon-color=\"#333\" data-text-color=\"#333\" data-client-id=\"block-6e1d189b-ca6b-403a-b5ab-26e4c8c81431\"><ul class=\"first-level\"><li>PREVYMIS has received a B-I recommendation<sup>a<\/sup> through 200 days for high-risk HSCT recipients<\/li><\/ul><\/div>\n\n\n\n<div style=\"background-color:transparent;height:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-8\"><\/div>\n\n\n\n<p>Acyclovir-based prophylaxis for herpes simplex virus and herpes zoster virus is also recommended while on letermovir due to lack of activity of PREVYMIS against these 2 viruses (B-I).<sup>2<\/sup><\/p>\n\n\n\n<div style=\"background-color:transparent;height:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-16\"><\/div>\n\n\n\n<p>The safety and effectiveness of PREVYMIS have not been established for HSCT recipients less than 6 months of age or weighing less than 6 kg.<\/p>\n\n\n\n<div style=\"background-color:transparent;height:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-16 spacer-undefined\"><\/div>\n\n\n\n<p><strong>PREVYMIS\u00ae (letermovir) primary prophylaxis recommended for pediatric CMV R+ allogeneic HSCT recipients (A-II)<sup>2<\/sup>:<\/strong><\/p>\n\n\n\n<div style=\"background-color:transparent;height:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-8\"><\/div>\n\n\n\n<div class=\"vivid-block-list content-width  default-list block-78d46d35-72a6-48a8-8d67-b83d9c5f792a\" data-image=\"\" data-image-mobile=\"\" data-image-all=\"\" data-image-all-mobile=\"\" data-icon-color=\"#333\" data-text-color=\"#333\" data-client-id=\"block-78d46d35-72a6-48a8-8d67-b83d9c5f792a\"><ul class=\"first-level\"><li>PREVYMIS has received an A-II recommendation<sup>a<\/sup> for pediatric patients<\/li><\/ul><\/div>\n\n\n\n<div style=\"background-color:transparent;height:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-8\"><\/div>\n\n\n\n<p>Acyclovir-based prophylaxis for herpes simplex virus and herpes zoster virus is also recommended while on letermovir due to lack of activity of PREVYMIS against these 2 viruses (B-I).<sup>2<\/sup><\/p>\n\n\n\n<div style=\"background-color:transparent;height:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-16\"><\/div>\n\n\n\n<p><\/p>\n\n\n\n<p class=\"has-small-font-size\"><sup>a<\/sup>Strength of the recommendation<sup>1,3<\/sup>:<br>A \u2013 highest strength of recommendation: should always be offered; B \u2013 should generally be offered. <\/p>\n\n\n\n<p class=\"has-small-font-size\">Quality of evidence supporting the recommendation<sup>3<\/sup>: \u2028<\/p>\n\n\n\n<p class=\"has-small-font-size\">I \u2013 evidence from at least one properly randomized, controlled trial; II \u2013 evidence for at least one well-designed clinical trial without randomization, from cohort or case-controlled analytic studies (preferable from more than one center) or from multiple time-series, or dramatic results from uncontrolled experiments.<\/p>\n\n\n\n<div style=\"background-color:transparent;height:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-16\"><\/div>\n\n\n\n<div class=\"vivid360-heading\" id=\"a57dd5038-c0b3-4bf8-939a-8da6bd5b55fd\"><h3 class=\"content-width fontWeightRegular\" style=\"--desktopFontSize:18px;--tabletFontSize:var(--h3FontSizeDesktop);--mobileFontSize:18px;--desktopLineHeightSize:27px;--tabletLineHeightSize:var(--h3LineHeightDesktop);--mobileLineHeightSize:\" id=\"\">References<\/h3><\/div>\n\n\n\n<div class=\"vivid-block-list content-width  block-1f0090f5-b15a-4527-a493-f0595e2d671f\" data-image=\"\" data-image-mobile=\"\" data-image-all=\"\" data-image-all-mobile=\"\" data-icon-color=\"#333\" data-text-color=\"#333\" data-client-id=\"block-1f0090f5-b15a-4527-a493-f0595e2d671f\"><ol class=\"first-level default-order\"><li>Hakki M, Aitken SL, Danziger-Isakov L, et al. American Society for Transplantation and Cellular Therapy series: #3\u2014prevention of cytomegalovirus infection and disease after hematopoietic cell transplantation. <em>Transplant Cell<\/em> <em>Ther<\/em>. 2021;27(9):707-719. https:\/\/doi.org\/10.1016\/j.jtct.2021.05.001<\/li><li>Khawaja F, Zamora D, Yong MK, et al. American Society for Transplantation and Cellular Therapy Series #11: updated cytomegalovirus guidelines in hematopoietic cell transplant and cellular therapy recipients. <em>Transplant Cell<\/em> <em>Ther<\/em>. Published 2025. doi:10.1016\/j.jtct.2025.06.025<\/li><li>Carpenter PA, Papanicolaou G, Chemaly RF, Boeckh M, Savani BN. American Society for Transplantation and Cellular Therapy infectious disease guidelines: preface to the series. <em>Transplant Cell Ther<\/em>. 2021;27(2):103-104. doi:10.1016\/j.jtct.2020.10.004<\/li><\/ol><\/div>\n\n\n\n<div style=\"background-color:transparent;height:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-16\"><\/div>\n\n\n\n<p><a href=\"#top\" aria-label=\"#\">Back to top<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>2021 ASTCT Guideline Excerpts PREVYMIS\u00ae (letermovir) primary prophylaxis is recommended for adult CMV R+ allogeneic HSCT recipients to begin no later than&#8230;<\/p>\n","protected":false},"author":699,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_trash_the_other_posts":false,"editor_notices":[],"footnotes":""},"ga4_page_audience":[],"ga4_page_birn_id":[],"ga4_page_branding":[270],"ga4_page_businessunit":[],"ga4_page_campaign":[],"ga4_page_content_purpose":[300],"ga4_page_customer_journey_stage":[336],"ga4_page_customer_specialty":[361],"ga4_page_experience":[],"ga4_page_indication":[],"ga4_page_material_intent":[576],"ga4_page_product":[599],"ga4_page_region":[910],"ga4_page_therapeuticarea":[],"user_role":[],"mhh-area-of-interest":[],"access":[],"user_status":[],"class_list":["post-74","page","type-page","status-publish"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ASTCT Practice Guidelines for Prevention of Cytomegalovirus (CMV) 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