{"id":2056,"date":"2025-04-03T09:23:47","date_gmt":"2025-04-03T09:23:47","guid":{"rendered":"https:\/\/www.merckconnect.com\/verquvo\/?page_id=2056"},"modified":"2026-03-30T10:18:05","modified_gmt":"2026-03-30T10:18:05","slug":"home","status":"publish","type":"page","link":"https:\/\/www.merckconnect.com\/verquvo\/","title":{"rendered":"Verquvo Home"},"content":{"rendered":"\n\n
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Actor Portrayal<\/div><\/div>
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VERQUVO Overview<\/strong><\/h1>

Add VERQUVO to provide a stabilizing force when your patient needs it most<\/p>

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Dosage & administration<\/h2>

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Clinical data<\/h2>

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Patients\u2019 hearts may never be the same after a HF hospitalization1,2<\/sup><\/h2><\/div>\n\n\n\n
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Patients with WHF face residual risks, whether they are hospitalized or receive outpatient IV diuretics<\/strong>3<\/strong><\/sup><\/h3><\/div>\n\n\n\n
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a<\/sup>Based on a retrospective, observational cohort analysis of the PINNACLE registry between January 2011 and December 2014 of 11,064 patients with newly diagnosed HFrEF. Of these patients, 1,851 developed WHF.4<\/sup><\/p>\n\n\n\n

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b<\/sup>WHF in this cohort was defined as patients who were free from hospitalization and IV diuretic use for \u226590 days from HFrEF diagnosis and subsequently required IV diuretics or HFH.4<\/sup><\/p>\n\n\n\n

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c<\/sup>In a retrospective, observational cohort analysis of the GWTG-HF. This analysis included 113,348 patients who were hospitalized for worsening chronic HFrEF \u226440% between 2014-2019 and discharged alive, of which 20,387 were aged \u226565 years and linked to Medicare claims.5<\/sup><\/p>\n\n\n\n

GWTG-HF, Get With The Guidelines-Heart Failure; HF, heart failure; HFH, heart failure hospitalization; HFrEF, heart failure with reduced ejection fraction; IV, intravenous; WHF, worsening heart failure.<\/p>\n\n\n\n

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References:<\/strong><\/h2><\/div>\n\n\n\n\n
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  1. Gheorghiade M, Marti CN, Sabbah HN, et al. Soluble guanylate cyclase: a potential therapeutic target for heart failure. Heart Fail Rev.<\/em> 2013;18:123-134.<\/li>\n\n\n\n
  2. Shah KS, Xu H, Matsouaka RA, et al. Heart failure with preserved, borderline, and reduced ejection fraction: 5-year outcomes. J Am Coll Cardiol.<\/em> 2017;70(20):2476-2486.<\/em><\/li>\n\n\n\n
  3. Greene SJ, Bauersachs J, Brugts JJ, et al. Worsening heart failure: nomenclature, epidemiology, and future directions: JACC Review Topic of the Week. J Am Coll Cardiol.<\/em> 2023;81(4):413-424.<\/li>\n\n\n\n
  4. Butler J, Yang M, Manzi MA, et al. Clinical course of patients with worsening heart failure with reduced ejection fraction. J Am Coll Cardiol. <\/em>2019;73(8):935-944.<\/li>\n\n\n\n
  5. Harrington J, Sun JL, Fonarow GC, et al. Clinical profile, health care costs, and outcomes of patients hospitalized for heart failure with severely reduced ejection fraction. J Am Heart Assoc. <\/em>2023;12:e028820. doi:10.1161\/JAHA.122.028820<\/li>\n<\/ol>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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