{"id":266,"date":"2023-09-06T17:32:27","date_gmt":"2023-09-06T17:32:27","guid":{"rendered":"https:\/\/www.merckconnect.com\/winrevair\/?page_id=266"},"modified":"2026-04-02T07:46:38","modified_gmt":"2026-04-02T07:46:38","slug":"dosage","status":"publish","type":"page","link":"https:\/\/www.merckconnect.com\/winrevair\/dosage\/","title":{"rendered":"Dosage and Administration"},"content":{"rendered":"\n\n
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For appropriate patients,<\/strong><\/h2><\/div>\n\n\n\n
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WINREVAIRTM<\/sup> (sotatercept-csrk) offers the convenience of at-home administration with 1 subcutaneous injection every 3 weeks<\/span><\/strong><\/h1><\/div>\n\n\n\n
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WINREVAIR is intended for use under the guidance of a healthcare professional (HCP). Patients and caregivers may administer WINREVAIR when deemed appropriate by their HCP with guidance, training, and follow-up on how to reconstitute, prepare, measure and inject WINREVAIR.<\/strong><\/li>\n<\/ul>\n<\/div>\n\n\n\n
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WINREVAIR dose is according to patient body weight. Consult the Prescribing Information for weight-based injection volumes per dose.<\/strong><\/li>\n<\/ul>\n<\/div>\n\n\n\n
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Scroll down to view additional dosage information and Injection Volume Calculator.<\/strong><\/h3><\/div>\n\n\n\n\n
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The recommended STARTING DOSE is 0.3 mg\/kg<\/span><\/mark><\/strong><\/h3>
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Obtain hemoglobin (Hgb) and platelet count prior to the first dose of WINREVAIR.<\/strong><\/li>\n<\/ul>\n<\/div>\n\n\n\n
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Do not initiate treatment if platelet count is <50,000\/mm3<\/sup> (<50×109<\/sup>\/L<\/strong>).<\/li>\n<\/ul>\n<\/div>\n<\/div><\/div><\/div><\/div>\n\n\n\n
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Injection volume for starting dose is calculated based on patient weight as follows:<\/p>\n<\/div>\n<\/div>\n\n\n\n
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Injection volume should be rounded to the nearest 0.1 mL.\u2028<\/p>\n\n\n\n
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For example: (70 kg x 0.3 mg\/kg) \u00f7 50 mg\/mL<\/span> = 0.42, rounds to 0.4 mL.<\/p>\n<\/div>\n<\/div>\n\n\n\n
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See the table below for selecting the appropriate kit based on calculated injection volume for starting dose.<\/p>\n\n\n\n
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Kit type based on injection volume for dose of 0.3 mg\/kg<\/strong><\/h3><\/div>\n\n\n\n
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Injection volume (mL)<\/span><\/th>
Kit Type<\/th><\/tr><\/thead>
0.2 to 0.9<\/td>
45 mg kit (containing 1 x 45 mg vial)<\/span><\/td><\/tr>
1 to 1.1<\/td>
60 mg kit (containing 1 x 60 mg vial)<\/span><\/td><\/tr><\/tbody><\/table>
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The recommended TARGET DOSE is 0.7 mg\/kg<\/span><\/mark><\/strong><\/h3>
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After verifying acceptable Hgb and platelet count, increase to the target dose of 0.7 mg\/kg.<\/strong><\/li>\n<\/ul>\n<\/div>\n\n\n\n
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Continue treatment at 0.7 mg\/kg<\/span> every 3 weeks unless dosage adjustments are required.<\/strong><\/li>\n<\/ul>\n<\/div>\n<\/div><\/div><\/div><\/div>\n\n\n\n
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Injection volume for target dose is calculated based on patient weight as follows:<\/p>\n<\/div>\n<\/div>\n\n\n\n
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Injection volume should be rounded to the nearest 0.1 mL.\u2028<\/p>\n\n\n\n
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For example: (70 kg x 0.7 mg\/kg) \u00f7 50 mg\/mL<\/span> = 0.98, rounds to 1 mL.<\/p>\n<\/div>\n<\/div>\n\n\n\n
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See the table below for selecting the appropriate kit based on calculated injection volume for target dose.<\/p>\n\n\n\n
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Kit type based on injection volume for dose of 0.7 mg\/kg<\/strong><\/h3><\/div>\n\n\n\n
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Injection volume (mL)<\/span><\/th>
Kit Type<\/th><\/tr><\/thead>
0.4 to 0.9<\/td>
45 mg kit (containing 1 x 45 mg vial)<\/span><\/td><\/tr>
1 to 1.2<\/td>
60 mg kit (containing 1 x 60 mg vial)<\/span><\/td><\/tr>
1.3 to 1.8<\/td>
90 mg kit (containing 2 x 45 mg vials)<\/span><\/td><\/tr>
1.9 to 2.4<\/td>
120 mg kit (containing 2 x 60 mg vials)<\/span><\/td><\/tr><\/tbody><\/table>
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Missed dose, overdose, and underdose<\/strong><\/h3><\/div>\n\n\n\n
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If a dose of WINREVAIR is missed, administer as soon as possible.<\/li>\n<\/ul>\n\n\n\n
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If the missed dose of WINREVAIR is not administered within 3 days of the scheduled date, adjust the schedule to maintain 3-week dosing intervals.<\/li>\n<\/ul>\n\n\n\n
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In case of an overdose, monitor for erythrocytosis.<\/li>\n<\/ul>\n<\/div>\n\n\n\n
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Dosage modifications due to Hgb increase or platelet count decrease<\/strong><\/h3><\/div>\n\n\n\n
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Check Hgb and platelet count before each dose for the first 5 doses, or longer if values are unstable. Thereafter, monitor Hgb and platelet count periodically.<\/mark><\/strong><\/h3>
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Delay treatment for at least 3 weeks if any of the following occur:<\/mark><\/strong><\/h3>
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Hgb increases >2.0 g\/dL from the previous dose and is above upper limit of normal (ULN)<\/li>\n\n<\/ul>\n\n<\/div>\n\n\n
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Hgb increases >4.0 g\/dL from baseline<\/li>\n\n<\/ul>\n\n<\/div>\n\n\n
Platelet count decreases to <50,000\/mm\u00b3 (<50.0 x 10\u2079\/L)<\/li>\n\n<\/ul>\n\n<\/div>\n\n\n
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Recheck Hgb and platelet count before reinitiating treatment. For treatment delays lasting >9 weeks, restart treatment at 0.3 mg\/kg<\/span> and escalate to 0.7 mg\/kg<\/span> after verifying acceptable Hgb and platelet count.<\/mark><\/strong><\/p>\n\n<\/div><\/div><\/div><\/div>\n\n\n\n
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Injection Volume Calculator<\/strong><\/h3>
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Calculates injection volume based on dose and patient weight<\/p>\n\n\n\n
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