{"id":7129,"date":"2025-07-28T10:31:33","date_gmt":"2025-07-28T10:31:33","guid":{"rendered":"https:\/\/www.merckconnect.com\/winrevair\/?page_id=7129"},"modified":"2026-04-02T07:39:04","modified_gmt":"2026-04-02T07:39:04","slug":"pah-ctd-patient-profile","status":"publish","type":"page","link":"https:\/\/www.merckconnect.com\/winrevair\/pah-ctd-patient-profile\/","title":{"rendered":"Patient profile"},"content":{"rendered":"\n\n
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For patients like Jackie – consider adding WINREVAIRTM<\/sup> (sotatercept-csrk) to your appropriate patients’ PAH treatment regimen<\/h1><\/div>\n\n\n\n
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Hypothetical patient<\/strong><\/p><\/figcaption><\/figure><\/div>\n<\/div>\n\n\n\n

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Meet Jackie<\/strong><\/h2><\/div>\n\n\n\n

age 46, diagnosed with PAH-CTD 9 months ago.<\/strong> Jackie has ongoing symptoms with moderate physical exertion. She is currently prescribed an endothelin receptor antagonist (ERA) + phosphodiesterase 5 inhibitor (PDE5i), but she remains at WHO FC II with an intermediate risk profile.<\/p><\/div><\/div>\n\n\n\n

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<\/th>At diagnosis<\/span><\/th>3 months<\/span> ago<\/th>Current<\/th><\/tr><\/thead>
6MWD<\/strong><\/td>390 m<\/td>400 m<\/td>410 m<\/td><\/tr>
PVR<\/strong><\/td>10 Wood units<\/span><\/td>–<\/td>8.2 Wood units<\/span><\/td><\/tr>
ECHO<\/strong><\/td>–<\/td>Mild RV dilation
Moderate RV dysfunction
TAPSE 14 mm<\/span>
No pericardial effusion<\/td>		Mild RV dilation
Moderate RV dysfunction
TAPSE 14 mm<\/span>
Small pericardial effusion<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
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6MWD = 6-minute walk distance; ECHO = echocardiogram; PAH-CTD = pulmonary arterial hypertension associated with connective tissue disease; PVR = pulmonary vascular resistance; RV = right ventricular; TAPSE = tricuspid annular plane systolic excursion.<\/p><\/div><\/div>\n\n\n\n

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Report exposure during pregnancy or lactation to the Merck Sharp & Dohme<\/span> LLC Adverse Event reporting line at 1-877-888-4231<\/span><\/strong><\/h6><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n
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<\/p>\n","protected":false},"excerpt":{"rendered":"

6MWD = 6-minute walk distance; ECHO = echocardiogram; PAH-CTD = pulmonary arterial hypertension associated with connective tissue disease; PVR = pulmonary vascular…<\/p>\n","protected":false},"author":389,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_trash_the_other_posts":false,"editor_notices":[],"footnotes":""},"ga4_page_audience":[911],"ga4_page_birn_id":[],"ga4_page_branding":[271],"ga4_page_businessunit":[278],"ga4_page_campaign":[],"ga4_page_content_purpose":[310],"ga4_page_customer_journey_stage":[338],"ga4_page_customer_specialty":[396],"ga4_page_experience":[],"ga4_page_indication":[507],"ga4_page_material_intent":[526],"ga4_page_product":[941],"ga4_page_region":[814],"ga4_page_therapeuticarea":[856],"user_role":[],"mhh-area-of-interest":[],"access":[],"user_status":[],"class_list":["post-7129","page","type-page","status-publish"],"yoast_head":"\nPatient Profile: PAH-CTD With Ongoing 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