{"id":7355,"date":"2026-04-01T16:12:02","date_gmt":"2026-04-01T16:12:02","guid":{"rendered":"https:\/\/www.merckconnect.com\/winrevair\/?page_id=7355"},"modified":"2026-04-02T14:11:16","modified_gmt":"2026-04-02T14:11:16","slug":"nct04576988-efficacy-primary-endpoint","status":"publish","type":"page","link":"https:\/\/www.merckconnect.com\/winrevair\/nct04576988-efficacy-primary-endpoint\/","title":{"rendered":"Primary endpoint data"},"content":{"rendered":"<link rel='stylesheet' id='vivid360-spacer-css-css' href='https:\/\/www.merckconnect.com\/winrevair\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/spacer\/css\/style.min.css?ver=1766071753' media='all' \/>\n\n<div style=\"background-color:transparent;height:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-16\"><\/div>\n\n\n\n<div class=\"wp-block-columns are-vertically-aligned-top mb-0 is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:70px\"><\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\"><link rel='stylesheet' id='vivid360-heading-css-css' href='https:\/\/www.merckconnect.com\/winrevair\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/heading\/css\/style.min.css?ver=1766071753' media='all' \/>\n\n<div class=\"vivid360-heading\" id=\"a1ecdb761-70bb-4947-83df-7aac9169d110\"><h2 class=\"has-secondary-2-color content-width fontWeightRegular\" style=\"--desktopFontSize:24px;--tabletFontSize:20px;--mobileFontSize:20px;--desktopLineHeightSize:36px;--tabletLineHeightSize:30px;--mobileLineHeightSize:\" id=\"\"><strong>Primary endpoint: 6-minute walk<\/strong> <strong>distance (6MWD)<\/strong><\/h2><\/div>\n\n\n\n<div style=\"background-color:transparent;height:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-8\"><\/div>\n\n\n\n<div class=\"wp-block-columns are-vertically-aligned-top is-not-stacked-on-mobile is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"column-wrapper _526309a5-ee28-4c01-b4b6-61290888a656\"><style>\n\t\t\t\t@media (min-width: 1024px) {\n\t\t\t\t\t.column-wrapper {\n\t\t\t\t\t\tdisplay: contents;\n\t\t\t\t\t}\n\t\t\t\t}\n\t\t\t\t@media (max-width: 1024px) {\n\t\t\t\t\t#block-526309a5-ee28-4c01-b4b6-61290888a656,\n\t\t\t\t\t._526309a5-ee28-4c01-b4b6-61290888a656 {\n\t\t\t\t\t\tdisplay: contents;\n\t\t\t\t\t\t\n\t\t\t\t\t}\n\t\t\t\t\t.wp-block-columns:not(.is-not-stacked-on-mobile)>.column-wrapper {\n\t\t\t\t\t\tflex-basis: 100% !important;\n\t\t\t\t\t}\n\t\t\t\t\t.column-wrapper .wp-block-column {\n\t\t\t\t\t\torder: inherit;\n\t\t\t\t\t}\n\t\t\t\t}\n\t\t\t\t@media (max-width: 767px) {\n\t\t\t\t\t#block-526309a5-ee28-4c01-b4b6-61290888a656,\n\t\t\t\t\t._526309a5-ee28-4c01-b4b6-61290888a656 {\n\t\t\t\t\t\tflex-basis: 25% !important;display: unset !important;\n\t\t\t\t\t\t\n\t\t\t\t\t}\n\t\t\t\t\t.column-wrapper .wp-block-column {\n\t\t\t\t\t\torder: inherit;\n\t\t\t\t\t}\n\t\t\t\t}\n\t\t\t\t<\/style><div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:8%\"><link rel='stylesheet' id='vivid360-image-css-css' href='https:\/\/www.merckconnect.com\/winrevair\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/image\/css\/style.min.css?ver=1766071753' media='all' \/>\n\n<div class=\"wp-block-vivid360-image img-container mb-0 ml-0 mt-0 mr-0\"><figure class=\"wp-block-vivid360-image is-style-default size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.merckconnect.com\/winrevair\/wp-content\/uploads\/sites\/112\/2026\/04\/STELLAR-icon-1_94702a.svg\" alt=\"\" class=\"wp-image-7356  style-noshadow   \" width=\"80\" height=\"80\" style=\"height:80px;width:80px\"\/><\/figure><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"column-wrapper _27c8b5f6-95a3-4649-b834-11cf40817012\"><style>\n\t\t\t\t@media (min-width: 1024px) {\n\t\t\t\t\t.column-wrapper {\n\t\t\t\t\t\tdisplay: contents;\n\t\t\t\t\t}\n\t\t\t\t}\n\t\t\t\t@media (max-width: 1024px) {\n\t\t\t\t\t#block-27c8b5f6-95a3-4649-b834-11cf40817012,\n\t\t\t\t\t._27c8b5f6-95a3-4649-b834-11cf40817012 {\n\t\t\t\t\t\tdisplay: contents;\n\t\t\t\t\t\t\n\t\t\t\t\t}\n\t\t\t\t\t.wp-block-columns:not(.is-not-stacked-on-mobile)>.column-wrapper {\n\t\t\t\t\t\tflex-basis: 100% !important;\n\t\t\t\t\t}\n\t\t\t\t\t.column-wrapper .wp-block-column {\n\t\t\t\t\t\torder: inherit;\n\t\t\t\t\t}\n\t\t\t\t}\n\t\t\t\t@media (max-width: 767px) {\n\t\t\t\t\t#block-27c8b5f6-95a3-4649-b834-11cf40817012,\n\t\t\t\t\t._27c8b5f6-95a3-4649-b834-11cf40817012 {\n\t\t\t\t\t\tflex-basis: 75% !important;display: unset !important;\n\t\t\t\t\t\t\n\t\t\t\t\t}\n\t\t\t\t\t.column-wrapper .wp-block-column {\n\t\t\t\t\t\torder: inherit;\n\t\t\t\t\t}\n\t\t\t\t}\n\t\t\t\t<\/style><div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:92%\">\n<div class=\"vivid360-heading\" id=\"a7ffb318e-562e-4840-8e56-2db59e1166b3\"><h4 class=\"has-primary-color content-width fontWeightRegular\" style=\"--desktopFontSize:18px;--tabletFontSize:16px;--mobileFontSize:16px;--desktopLineHeightSize:27px;--tabletLineHeightSize:24px;--mobileLineHeightSize:\" id=\"\"><strong>In STELLAR, a 24-week study of adults with PAH (WHO FC II or III) on background therapy:<\/strong><\/h4><\/div>\n\n\n\n<div class=\"vivid360-heading\" id=\"a48809c43-6999-4bd8-97e4-fe38f79c402e\"><h1 class=\"has-primary-color content-width fontWeightRegular\" style=\"--desktopFontSize:30px;--tabletFontSize:22px;--mobileFontSize:22px;--desktopLineHeightSize:45px;--tabletLineHeightSize:33px;--mobileLineHeightSize:\" id=\"\"><strong>WINREVAIR<sup>TM<\/sup> (sotatercept-csrk) delivered a significant step forward for patients<\/strong><\/h1><\/div>\n<\/div><\/div>\n<\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:8px;--tablet-spacer:20px;--mobile-spacer:20px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<div class=\"wp-block-columns mb-0 is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:29%\"><link rel='stylesheet' id='vivid360-image-module-css-css' href='https:\/\/www.merckconnect.com\/winrevair\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/image-module\/css\/style.min.css?ver=1766071753' media='all' \/>\n\n<div id=\"\" class=\"wp-block-vivid360-image-module ratio-50-50 content-above one-col full-page-width\"><div class=\"vivid360-block-image-module__content-wrapper content-align-left\" id=\"contentDiv\"><\/div><figure class=\"vivid360-block-image-module__image-container\"><picture><source media=\"(max-width: 767px)\" data-srcset=\"https:\/\/www.merckconnect.com\/winrevair\/wp-content\/uploads\/sites\/112\/2025\/07\/1-1_5dfbc7.png?w=767\"\/><source media=\"(min-width: 768px) and (max-width: 1440px)\" data-srcset=\"https:\/\/www.merckconnect.com\/winrevair\/wp-content\/uploads\/sites\/112\/2025\/07\/1-1.png?w=1440\"\/><img decoding=\"async\" width=\"792\" height=\"558\" data-src=\"https:\/\/www.merckconnect.com\/winrevair\/wp-content\/uploads\/sites\/112\/2025\/07\/1-1.png\" loading=\"lazy\" src=\"https:\/\/www.merckconnect.com\/winrevair\/wp-content\/uploads\/sites\/112\/2025\/07\/1-1.png\" alt=\"\"\/><\/picture><figcaption class=\"caption-align-left noCaptionText\" id=\"figcaption\"><p class=\"caption-title vivid360-block-image-module__caption\" style=\"--captionFontSize:14px;--captionFontSizeTablet:14px;--captionFontSizeMobile:14px\"><\/p><\/figcaption><\/figure><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:2px;--tablet-spacer:2px;--mobile-spacer:2px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<p class=\"has-small-font-size\">Actor Portrayal<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:71%\">\n<div class=\"paragraph-wrapper wp-elements-2e39d9027909fa446b1f03aeee0f1807\"><div class=\"_110ffb61-8b9f-4b42-aaa1-00253c29c8a9 \" id=\"\"><p class=\"has-secondary-2-color has-text-color has-link-color has-medium-font-size\">Patients taking WINREVAIR walked<\/p><\/div><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:0px;--tablet-spacer:4px;--mobile-spacer:4px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<div class=\"paragraph-wrapper\"><div class=\"_4ab775d4-8f90-4f12-8af8-91026b1a2ba2 \" id=\"\"><p style=\"font-size:30px\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-secondary-2-color\">41 meters more<\/mark><\/strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-secondary-2-color\">\u1d43<\/mark><strong> <\/strong><span class=\"no-wrap-text\"><span class=\"footnote-text\">(95% CI: 28: 54; <em>P<\/em>&lt;0.001)<\/span><\/span><\/p><\/div><\/div>\n\n\n\n<div class=\"paragraph-wrapper wp-elements-5b9375070c8d5a6d3c3b337690c88516\"><div class=\"_8f5eb033-ae5e-407f-8f07-128aeca70b46 mt-0\" id=\"\"><p class=\"has-secondary-2-color has-text-color has-link-color\" style=\"font-size:18px\">in 6 minutes at 24 weeks than patients on background therapy alone<\/p><\/div><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:8px;--tablet-spacer:4px;--mobile-spacer:4px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<div class=\"paragraph-wrapper wp-elements-7921732408217d2af0f1902a3816e361\"><div class=\"_5c24de8c-539d-43ab-ab55-4fb31e78e7e9 \" id=\"\"><p class=\"has-dark-text-color has-text-color has-link-color has-regular-font-size\">Placebo-adjusted median increase from baseline in 6MWD<\/p><\/div><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:16px;--tablet-spacer:8px;--mobile-spacer:0px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n<\/div>\n<\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:8px;--tablet-spacer:0px;--mobile-spacer:0px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<div class=\"vivid360-heading\" id=\"a04d36dc8-d744-435c-9871-5e27c458eb4b\"><h4 class=\"has-primary-color content-width fontWeightRegular mt-0\" style=\"--desktopFontSize:18px;--tabletFontSize:16px;--mobileFontSize:16px;--desktopLineHeightSize:27px;--tabletLineHeightSize:24px;--mobileLineHeightSize:\" id=\"\"><strong>In a 24-week clinical study of adults with PAH (WHO Group 1, FC II or III) on stable background therapy, patients (N=323) were randomized 1:1 to WINREVAIR (n=163) or placebo (n=160) administered by subcutaneous injection once every 3 weeks.<sup>1<\/sup><\/strong><\/h4><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:8px;--tablet-spacer:24px;--mobile-spacer:24px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<div class=\"vivid360-heading\" id=\"aed50ae4c-059a-4ccf-8e84-f3f08cc4444c\"><h2 class=\"has-primary-color has-text-align-center content-width fontWeightRegular\" style=\"--desktopFontSize:24px;--tabletFontSize:20px;--mobileFontSize:20px;--desktopLineHeightSize:36px;--tabletLineHeightSize:30px;--mobileLineHeightSize:;--tabletAlign:center;--mobileAlign:center\" id=\"\"><strong>Change from baseline in 6MWD at week 24 in subgroups in STELLAR<\/strong><sup>a,b<\/sup><\/h2><\/div>\n\n\n\n<figure class=\"wp-block-flexible-table-block-table is-scroll-on-mobile\"><table class=\"has-fixed-layout\"><tbody><tr><td style=\"font-size:18px;width:220px;border-width:0;border-color:#bbbcc9\"><\/td><td style=\"font-size:18px;border-width:0;border-color:#bbbcc9;text-align:center;color:#ce1e5a;width:130px;vertical-align:bottom\"><strong>WINREVAIR<br><\/strong>(n=163)<\/td><td style=\"text-align:center;border-width:0;vertical-align:bottom;font-size:18px;width:100px;border-color:#bbbcc9\">Placebo<br>(n=160)<\/td><td colspan=\"2\" style=\"border-width:0;color:#3b3b3b;vertical-align:bottom;font-size:18px;text-align:center;width:220px;border-color:#bbbcc9;padding-right:0;padding-left:0\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#ce1e5a\" class=\"has-inline-color\">WINREVAIR<\/mark><\/strong> <strong>vs placebo<\/strong><br>Hodges-Lehmann location shift (95% CI)<\/td><td style=\"border-width:0;color:#3b3b3b;vertical-align:bottom;font-size:18px;border-color:#bbbcc9;text-align:center;width:300px\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#ce1e5a\" class=\"has-inline-color\">WINREVAIR<\/mark> vs placebo<br><\/strong>Hodges-Lehmann location<br>shift (asymptotic standard error) (95% CI)<\/td><\/tr><tr><td style=\"background-color:#ecf1e5;width:220px;border-color:#bbbcc9;padding-top:0;padding-bottom:0;line-height:0;font-size:16px;color:#3b3b3b;text-align:left;vertical-align:middle\"><strong>Overall<\/strong><\/td><td style=\"text-align:center;background-color:#f6e3df;width:130px;border-color:#bbbcc9;padding-top:0;padding-bottom:0;font-size:16px;color:#3b3b3b;vertical-align:middle;line-height:0\">163<\/td><td style=\"text-align:center;background-color:#eff0f0;width:80px;border-color:#bbbcc9;padding-top:0;padding-bottom:0;line-height:0;font-size:16px;color:#3b3b3b;vertical-align:middle\">160<\/td><td colspan=\"2\" style=\"font-size:18px;width:220px;border-color:#bbbcc9;text-align:center;line-height:0;padding:0\"><img decoding=\"async\" class=\"wp-image-1063\" style=\"width: 260px;\" src=\"https:\/\/www.merckconnect.com\/winrevair\/wp-content\/uploads\/sites\/112\/2026\/04\/row-1-new.svg\" alt=\"\"><\/td><td style=\"width:240px;border-color:#bbbcc9;text-align:center;padding-top:0;padding-bottom:0;color:#3b3b3b;font-size:16px;vertical-align:middle\">40.8 (6.79) (27.53, 54.14)<\/td><\/tr><tr><td style=\"background-color:#ecf1e5;width:220px;border-color:#bbbcc9;padding-top:0;padding-bottom:0;line-height:0.8;font-size:16px;color:#3b3b3b;text-align:left;vertical-align:middle\"><strong>PAH diagnostic group<\/strong><\/td><td style=\"text-align:center;background-color:#f6e3df;width:130px;border-color:#bbbcc9;padding-top:0;padding-bottom:0;font-size:16px;color:#3b3b3b;vertical-align:middle;line-height:0\"><\/td><td style=\"text-align:center;background-color:#eff0f0;width:80px;border-color:#bbbcc9;padding-top:0;padding-bottom:0;line-height:0.8;font-size:16px;color:#3b3b3b;vertical-align:middle\"><\/td><td colspan=\"2\" style=\"background-color:#ecf1e5;font-size:18px;width:220px;border-color:#bbbcc9;text-align:center;line-height:0;padding:0\"><img decoding=\"async\" class=\"wp-image-1058\" style=\"width: 260px;\" src=\"https:\/\/www.merckconnect.com\/winrevair\/wp-content\/uploads\/sites\/112\/2026\/04\/row-blank-new.svg\" alt=\"\"><\/td><td style=\"background-color:#ecf1e5;font-size:16px;width:220px;border-color:#bbbcc9;text-align:center;padding-top:0;padding-bottom:0;line-height:0.8;color:#3b3b3b;vertical-align:middle\"><\/td><\/tr><tr><td style=\"width:220px;padding-top:0;padding-bottom:0;line-height:0.4;border-color:#bbbcc9;font-size:16px;color:#3b3b3b;text-align:left;vertical-align:middle\">Idiopathic PAH<\/td><td style=\"text-align:center;background-color:#f6e3df;width:130px;padding-right:0;padding-left:0;border-color:#bbbcc9;font-size:16px;color:#3b3b3b;vertical-align:middle;line-height:0\">83<\/td><td style=\"text-align:center;background-color:#eff0f0;width:80px;padding-top:0;padding-bottom:0;line-height:0.4;border-color:#bbbcc9;font-size:16px;color:#3b3b3b;vertical-align:middle\">106<\/td><td colspan=\"2\" style=\"font-size:18px;line-height:0.4;width:220px;border-color:#bbbcc9;text-align:center;padding:0\"><img decoding=\"async\" class=\"wp-image-972\" style=\"width: 260px;\" src=\"https:\/\/www.merckconnect.com\/winrevair\/wp-content\/uploads\/sites\/112\/2026\/04\/row-3.svg\" alt=\"\"><\/td><td style=\"font-size:16px;width:220px;padding-top:0;padding-bottom:0;line-height:0.4;border-color:#bbbcc9;text-align:center;color:#3b3b3b;vertical-align:middle\">51.3 (9.74) (32.17, 70.35)<\/td><\/tr><tr><td style=\"width:220px;padding-top:0;padding-bottom:0;line-height:0.4;border-color:#bbbcc9;font-size:16px;color:#3b3b3b;text-align:left;vertical-align:middle\">Heritable PAH<\/td><td style=\"text-align:center;background-color:#f6e3df;width:130px;padding-right:0;padding-left:0;border-color:#bbbcc9;font-size:16px;color:#3b3b3b;vertical-align:middle;line-height:0\">35<\/td><td style=\"text-align:center;background-color:#eff0f0;width:80px;padding-top:0;padding-bottom:0;line-height:0.4;border-color:#bbbcc9;font-size:16px;color:#3b3b3b;vertical-align:middle\">24<\/td><td colspan=\"2\" style=\"font-size:18px;line-height:0.4;width:220px;border-color:#bbbcc9;text-align:center;padding:0\"><img decoding=\"async\" class=\"wp-image-1022\" style=\"width: 260px;\" src=\"https:\/\/www.merckconnect.com\/winrevair\/wp-content\/uploads\/sites\/112\/2026\/04\/row-4.svg\" alt=\"\"><\/td><td style=\"font-size:16px;width:220px;padding-top:0;padding-bottom:0;line-height:0.4;border-color:#bbbcc9;text-align:center;color:#3b3b3b;vertical-align:middle\">25.6 (13.76) (-1.34, 52.61)<\/td><\/tr><tr><td style=\"width:220px;padding-top:0;padding-bottom:0;border-color:#bbbcc9;line-height:0.4;font-size:16px;color:#3b3b3b;text-align:left;vertical-align:middle\">Drug\/toxin-induced PAH<\/td><td style=\"text-align:center;background-color:#f6e3df;width:130px;padding-right:0;padding-left:0;border-color:#bbbcc9;font-size:16px;color:#3b3b3b;vertical-align:middle;line-height:0\">7<\/td><td style=\"text-align:center;background-color:#eff0f0;width:80px;padding-top:0;padding-bottom:0;border-color:#bbbcc9;line-height:0.4;font-size:16px;color:#3b3b3b;vertical-align:middle\">4<\/td><td colspan=\"2\" style=\"font-size:18px;width:220px;border-color:#bbbcc9;text-align:center;line-height:0.4;padding:0\"><img decoding=\"async\" class=\"wp-image-1023\" style=\"width: 260px;\" src=\"https:\/\/www.merckconnect.com\/winrevair\/wp-content\/uploads\/sites\/112\/2026\/04\/row-5.svg\" alt=\"\"><\/td><td style=\"font-size:16px;width:220px;padding-top:0;padding-bottom:0;border-color:#bbbcc9;text-align:center;line-height:0.4;color:#3b3b3b;vertical-align:middle\">18.4 (16.78) (-14.51, 51.25)<\/td><\/tr><tr><td style=\"width:220px;padding-top:0;padding-bottom:0;border-color:#bbbcc9;line-height:0.4;font-size:16px;color:#3b3b3b;text-align:left;vertical-align:middle\">CTD<\/td><td style=\"text-align:center;background-color:#f6e3df;width:130px;padding-right:0;padding-left:0;border-color:#bbbcc9;font-size:16px;color:#3b3b3b;vertical-align:middle;line-height:0\">29<\/td><td style=\"text-align:center;background-color:#eff0f0;width:80px;padding-top:0;padding-bottom:0;border-color:#bbbcc9;line-height:0.4;font-size:16px;color:#3b3b3b;vertical-align:middle\">19<\/td><td colspan=\"2\" style=\"font-size:18px;width:220px;border-color:#bbbcc9;text-align:center;line-height:0.4;padding:0\"><img decoding=\"async\" class=\"wp-image-1024\" style=\"width: 260px;\" src=\"https:\/\/www.merckconnect.com\/winrevair\/wp-content\/uploads\/sites\/112\/2026\/04\/row-6.svg\" alt=\"\"><\/td><td style=\"font-size:16px;width:220px;padding-top:0;padding-bottom:0;border-color:#bbbcc9;text-align:center;line-height:0.4;color:#3b3b3b;vertical-align:middle\">8.7 (17.96) (-26.55, 43.86)<\/td><\/tr><tr><td style=\"width:220px;padding-top:0;padding-bottom:0;border-color:#bbbcc9;line-height:0.4;font-size:16px;color:#3b3b3b;text-align:left;vertical-align:middle\">CHD with s\/p shunt repair<\/td><td style=\"text-align:center;background-color:#f6e3df;width:130px;padding-right:0;padding-left:0;border-color:#bbbcc9;font-size:16px;color:#3b3b3b;vertical-align:middle;line-height:0\">9<\/td><td style=\"text-align:center;background-color:#eff0f0;width:80px;padding-top:0;padding-bottom:0;border-color:#bbbcc9;line-height:0.4;font-size:16px;color:#3b3b3b;vertical-align:middle\">7<\/td><td colspan=\"2\" style=\"font-size:18px;width:220px;text-align:center;border-color:#bbbcc9;line-height:0.4;padding:0\"><img decoding=\"async\" class=\"wp-image-1025\" style=\"width: 260px;\" src=\"https:\/\/www.merckconnect.com\/winrevair\/wp-content\/uploads\/sites\/112\/2026\/04\/row-7.svg\" alt=\"\"><\/td><td style=\"font-size:16px;width:220px;padding-top:0;padding-bottom:0;border-color:#bbbcc9;text-align:center;line-height:0.4;color:#3b3b3b;vertical-align:middle\">92.4 (58.60) (-22.49, 207.26)<\/td><\/tr><tr><td style=\"width:220px;background-color:#ecf1e5;border-color:#bbbcc9;padding-top:0;padding-bottom:0;line-height:1;font-size:16px;color:#3b3b3b;text-align:left;vertical-align:middle\"><strong>Background therapy<\/strong><br><strong>at baseline<\/strong><\/td><td style=\"text-align:center;background-color:#f6e3df;font-size:16px;width:130px;border-color:#bbbcc9;padding-top:0;padding-bottom:0;color:#3b3b3b;vertical-align:middle;line-height:0\"><\/td><td style=\"text-align:center;background-color:#eff0f0;font-size:16px;width:80px;border-color:#bbbcc9;padding-top:0;padding-bottom:0;line-height:1;color:#3b3b3b;vertical-align:middle\"><\/td><td colspan=\"2\" style=\"background-color:#ecf1e5;font-size:16px;width:220px;border-color:#bbbcc9;text-align:center;line-height:0;padding:0\"><img decoding=\"async\" class=\"wp-image-1073\" style=\"width: 260px;\" src=\"https:\/\/www.merckconnect.com\/winrevair\/wp-content\/uploads\/sites\/112\/2026\/04\/row-blank-tall-v2.svg\" alt=\"\"><\/td><td style=\"background-color:#ecf1e5;font-size:16px;width:220px;border-color:#bbbcc9;text-align:center;padding-top:0;padding-bottom:0;line-height:1;color:#3b3b3b;vertical-align:middle\"><\/td><\/tr><tr><td style=\"width:220px;line-height:0.4;border-color:#bbbcc9;font-size:16px;color:#3b3b3b;text-align:left;vertical-align:middle\">Monotherapy<\/td><td style=\"text-align:center;background-color:#f6e3df;width:130px;border-color:#bbbcc9;font-size:16px;color:#3b3b3b;vertical-align:middle;line-height:0\">9<\/td><td style=\"text-align:center;background-color:#eff0f0;width:80px;line-height:0.4;border-color:#bbbcc9;font-size:16px;color:#3b3b3b;vertical-align:middle\">4<\/td><td colspan=\"2\" style=\"line-height:0.4;width:220px;border-color:#bbbcc9;text-align:center;padding:0\"><img decoding=\"async\" class=\"wp-image-1034\" style=\"width: 260px;\" src=\"https:\/\/www.merckconnect.com\/winrevair\/wp-content\/uploads\/sites\/112\/2026\/04\/row-9.svg\" alt=\"\"><\/td><td style=\"line-height:0.4;border-color:#bbbcc9;text-align:center;color:#3b3b3b;font-size:16px;vertical-align:middle;width:300px\">6.3 (534.33) (-564.54, 1530.01)<\/td><\/tr><tr><td style=\"width:220px;line-height:0.4;border-color:#bbbcc9;font-size:16px;color:#3b3b3b;text-align:left;vertical-align:middle\">Double<\/td><td style=\"text-align:center;background-color:#f6e3df;width:130px;border-color:#bbbcc9;font-size:16px;color:#3b3b3b;vertical-align:middle;line-height:0\">56<\/td><td style=\"text-align:center;background-color:#eff0f0;width:80px;line-height:0.4;border-color:#bbbcc9;font-size:16px;color:#3b3b3b;vertical-align:middle\">56<\/td><td colspan=\"2\" style=\"line-height:0.4;width:220px;border-color:#bbbcc9;text-align:center;padding:0\"><img decoding=\"async\" class=\"wp-image-1035\" style=\"width: 260px;\" src=\"https:\/\/www.merckconnect.com\/winrevair\/wp-content\/uploads\/sites\/112\/2026\/04\/row-10.svg\" alt=\"\"><\/td><td style=\"width:220px;line-height:0.4;border-color:#bbbcc9;text-align:center;color:#3b3b3b;font-size:16px;vertical-align:middle\">43.2 (11.32) (21.03, 65.42)<\/td><\/tr><tr><td style=\"width:220px;line-height:0.4;border-color:#bbbcc9;font-size:16px;color:#3b3b3b;text-align:left;vertical-align:middle\">Triple<\/td><td style=\"text-align:center;background-color:#f6e3df;width:130px;border-color:#bbbcc9;font-size:16px;color:#3b3b3b;vertical-align:middle;line-height:0\">98<\/td><td style=\"text-align:center;background-color:#eff0f0;width:80px;line-height:0.4;border-color:#bbbcc9;font-size:16px;color:#3b3b3b;vertical-align:middle\">100<\/td><td colspan=\"2\" style=\"line-height:0.4;width:220px;border-color:#bbbcc9;text-align:center;padding:0\"><img decoding=\"async\" class=\"wp-image-1036\" style=\"width: 260px;\" src=\"https:\/\/www.merckconnect.com\/winrevair\/wp-content\/uploads\/sites\/112\/2026\/04\/row-11.svg\" alt=\"\"><\/td><td style=\"width:220px;line-height:0.4;border-color:#bbbcc9;text-align:center;color:#3b3b3b;font-size:16px;vertical-align:middle\">43.5 (8.65) (26.51, 60.44)<\/td><\/tr><tr><td style=\"width:50%;background-color:#ecf1e5;line-height:1;border-color:#bbbcc9;padding-top:0;padding-bottom:0;font-size:16px;color:#3b3b3b;text-align:left;vertical-align:middle\"><strong>Prostacyclin infusion<br>therapy at baseline<\/strong><\/td><td style=\"background-color:#f6e3df;border-color:#bbbcc9;width:130px;padding-top:0;padding-bottom:0;font-size:16px;color:#3b3b3b;vertical-align:middle;line-height:0\"><\/td><td style=\"background-color:#eff0f0;line-height:1;border-color:#bbbcc9;width:80px;padding-top:0;padding-bottom:0;font-size:16px;color:#3b3b3b;vertical-align:middle;text-align:center\"><\/td><td colspan=\"2\" style=\"width:220px;background-color:#ecf1e5;line-height:0;border-color:#bbbcc9;text-align:center;padding:0\"><img decoding=\"async\" class=\"wp-image-1032\" style=\"width: 260px;\" src=\"https:\/\/www.merckconnect.com\/winrevair\/wp-content\/uploads\/sites\/112\/2026\/04\/row-blank-tall.svg\" alt=\"\"><\/td><td style=\"width:220px;background-color:#ecf1e5;line-height:1;border-color:#bbbcc9;text-align:center;padding-top:0;padding-bottom:0;color:#3b3b3b;font-size:16px;vertical-align:middle\"><\/td><\/tr><tr><td style=\"line-height:.50;border-color:#bbbcc9;font-size:16px;color:#3b3b3b;text-align:left;vertical-align:middle\">Yes<\/td><td style=\"background-color:#f6e3df;text-align:center;border-color:#bbbcc9;width:130px;font-size:16px;color:#3b3b3b;vertical-align:middle;line-height:0\">65<\/td><td style=\"background-color:#eff0f0;line-height:.50;text-align:center;border-color:#bbbcc9;width:80px;font-size:16px;color:#3b3b3b;vertical-align:middle\">64<\/td><td colspan=\"2\" style=\"line-height:0;border-color:#bbbcc9;width:220px;text-align:center;padding:0\"><img decoding=\"async\" class=\"wp-image-1037\" style=\"width: 260px;\" src=\"https:\/\/www.merckconnect.com\/winrevair\/wp-content\/uploads\/sites\/112\/2026\/04\/row-13.svg\" alt=\"\"><\/td><td style=\"line-height:.50;border-color:#bbbcc9;text-align:center;width:220px;color:#3b3b3b;font-size:16px;vertical-align:middle\">43.1 (10.45) (22.61, 63.59)<\/td><\/tr><tr><td style=\"line-height:.50;border-color:#bbbcc9;font-size:16px;color:#3b3b3b;text-align:left;vertical-align:middle\">No<\/td><td style=\"background-color:#f6e3df;text-align:center;border-color:#bbbcc9;width:130px;font-size:16px;color:#3b3b3b;vertical-align:middle;line-height:0\">98<\/td><td style=\"background-color:#eff0f0;line-height:.50;text-align:center;border-color:#bbbcc9;width:80px;font-size:16px;color:#3b3b3b;vertical-align:middle\">96<\/td><td colspan=\"2\" style=\"line-height:0;border-color:#bbbcc9;width:220px;text-align:center;padding:0\"><img decoding=\"async\" class=\"wp-image-1038\" style=\"width: 260px;\" src=\"https:\/\/www.merckconnect.com\/winrevair\/wp-content\/uploads\/sites\/112\/2026\/04\/row-14.svg\" alt=\"\"><\/td><td style=\"line-height:.50;border-color:#bbbcc9;text-align:center;width:220px;color:#3b3b3b;font-size:16px;vertical-align:middle\">38.6 (8.88) (21.20, 56.00)<\/td><\/tr><tr><td style=\"background-color:#ecf1e5;border-color:#bbbcc9;padding-top:0;padding-bottom:0;line-height:.8;font-size:16px;color:#3b3b3b;text-align:left;vertical-align:middle\"><strong>WHO FC<\/strong><\/td><td style=\"background-color:#f6e3df;text-align:center;border-color:#bbbcc9;width:130px;padding-top:0;padding-bottom:0;font-size:16px;color:#3b3b3b;vertical-align:middle;line-height:0\"><\/td><td style=\"background-color:#eff0f0;text-align:center;border-color:#bbbcc9;width:80px;padding-top:0;padding-bottom:0;line-height:.8;font-size:16px;color:#3b3b3b;vertical-align:middle\"><\/td><td colspan=\"2\" style=\"background-color:#ecf1e5;border-color:#bbbcc9;width:220px;text-align:center;line-height:0;padding:0\"><img decoding=\"async\" class=\"wp-image-1058\" style=\"width: 260px;\" src=\"https:\/\/www.merckconnect.com\/winrevair\/wp-content\/uploads\/sites\/112\/2026\/04\/row-blank-new.svg\" alt=\"\"><\/td><td style=\"background-color:#ecf1e5;border-color:#bbbcc9;text-align:center;width:220px;padding-top:0;padding-bottom:0;line-height:.8;color:#3b3b3b;font-size:16px;vertical-align:middle\"><\/td><\/tr><tr><td style=\"line-height:0.4;border-color:#bbbcc9;font-size:16px;color:#3b3b3b;text-align:left;vertical-align:middle\">II<\/td><td style=\"background-color:#f6e3df;text-align:center;border-color:#bbbcc9;width:130px;font-size:16px;color:#3b3b3b;vertical-align:middle;line-height:0\">79<\/td><td style=\"background-color:#eff0f0;line-height:0.4;text-align:center;border-color:#bbbcc9;width:80px;font-size:16px;color:#3b3b3b;vertical-align:middle\">78<\/td><td colspan=\"2\" style=\"line-height:0.4;border-color:#bbbcc9;width:220px;text-align:center;padding:0\"><img decoding=\"async\" class=\"wp-image-1039\" style=\"width: 260px;\" src=\"https:\/\/www.merckconnect.com\/winrevair\/wp-content\/uploads\/sites\/112\/2026\/04\/row-16.svg\" alt=\"\"><\/td><td style=\"line-height:0.4;border-color:#bbbcc9;text-align:center;width:220px;color:#3b3b3b;font-size:16px;vertical-align:middle\">21.7 (7.68) (6.63, 36.72)<\/td><\/tr><tr><td style=\"line-height:0.4;border-color:#bbbcc9;font-size:16px;color:#3b3b3b;text-align:left;vertical-align:middle\">III<\/td><td style=\"background-color:#f6e3df;text-align:center;border-color:#bbbcc9;width:130px;color:#3b3b3b;font-size:16px;line-height:0\">84<\/td><td style=\"background-color:#eff0f0;line-height:0.4;text-align:center;border-color:#bbbcc9;width:80px;font-size:16px;color:#3b3b3b;vertical-align:middle\">82<\/td><td colspan=\"2\" style=\"line-height:0.4;border-color:#bbbcc9;width:220px;text-align:center;padding:0\"><img decoding=\"async\" class=\"wp-image-1040\" style=\"width: 260px;\" src=\"https:\/\/www.merckconnect.com\/winrevair\/wp-content\/uploads\/sites\/112\/2026\/04\/row-17.svg\" alt=\"\"><\/td><td style=\"line-height:0.4;border-color:#bbbcc9;text-align:center;width:220px;color:#3b3b3b;font-size:16px;vertical-align:middle\">61.7 (10.64) (40.90, 82.59)<\/td><\/tr><tr><td style=\"background-color:#ecf1e5;border-color:#bbbcc9;line-height:0.8;width:220px;padding-top:0;padding-bottom:0;font-size:16px;color:#3b3b3b;text-align:left;vertical-align:middle\"><strong>Baseline PVR<\/strong><\/td><td style=\"background-color:#f6e3df;text-align:center;border-color:#bbbcc9;width:130px;padding-top:0;padding-bottom:0;font-size:16px;color:#3b3b3b;line-height:0\"><\/td><td style=\"background-color:#eff0f0;text-align:center;border-color:#bbbcc9;width:80px;line-height:0.8;padding-top:0;padding-bottom:0;font-size:16px;color:#3b3b3b;vertical-align:middle\"><\/td><td colspan=\"2\" style=\"background-color:#ecf1e5;border-color:#bbbcc9;width:220px;text-align:center;line-height:0;padding:0\"><img decoding=\"async\" class=\"wp-image-1058\" style=\"width: 260px;\" src=\"https:\/\/www.merckconnect.com\/winrevair\/wp-content\/uploads\/sites\/112\/2026\/04\/row-blank-new.svg\" alt=\"\"><\/td><td style=\"background-color:#ecf1e5;border-color:#bbbcc9;text-align:center;width:220px;line-height:0.8;padding-top:0;padding-bottom:0;color:#3b3b3b;font-size:16px;vertical-align:middle\"><\/td><\/tr><tr><td style=\"line-height:0.4;border-color:#bbbcc9;font-size:16px;color:#3b3b3b;text-align:left;vertical-align:middle\">\u2264 800 (dynes*sec\/cm<sup>5<\/sup>)<\/td><td style=\"background-color:#f6e3df;text-align:center;border-color:#bbbcc9;width:130px;font-size:16px;color:#3b3b3b;line-height:0\">108<\/td><td style=\"background-color:#eff0f0;line-height:0.4;text-align:center;border-color:#bbbcc9;width:80px;font-size:16px;color:#3b3b3b;vertical-align:middle\">108<\/td><td colspan=\"2\" style=\"line-height:0.4;border-color:#bbbcc9;width:220px;text-align:center;padding:0\"><img decoding=\"async\" class=\"wp-image-1041\" style=\"width: 260px;\" src=\"https:\/\/www.merckconnect.com\/winrevair\/wp-content\/uploads\/sites\/112\/2026\/04\/row-19.svg\" alt=\"\"><\/td><td style=\"line-height:0.4;border-color:#bbbcc9;text-align:center;width:220px;color:#3b3b3b;font-size:16px;vertical-align:middle\">30.8 (7.77) (15.54, 45.98)<\/td><\/tr><tr><td style=\"line-height:0.4;border-color:#bbbcc9;font-size:16px;color:#3b3b3b;text-align:left;vertical-align:middle\">&gt; 800 (dynes*sec\/cm<sup>5<\/sup>)<\/td><td style=\"background-color:#f6e3df;text-align:center;border-color:#bbbcc9;width:130px;font-size:16px;color:#3b3b3b;line-height:0\">55<\/td><td style=\"background-color:#eff0f0;line-height:0.4;text-align:center;border-color:#bbbcc9;width:80px;font-size:16px;color:#3b3b3b;vertical-align:middle\">52<\/td><td colspan=\"2\" style=\"line-height:0.4;border-color:#bbbcc9;width:220px;text-align:center;padding:0\"><img decoding=\"async\" class=\"wp-image-1042\" style=\"width: 260px;\" src=\"https:\/\/www.merckconnect.com\/winrevair\/wp-content\/uploads\/sites\/112\/2026\/04\/row-20.svg\" alt=\"\"><\/td><td style=\"line-height:0.4;border-color:#bbbcc9;text-align:center;width:220px;color:#3b3b3b;font-size:16px;vertical-align:middle\">61.6 (13.48) (35.23, 88.06)<\/td><\/tr><tr><td style=\"border-width:0;width:220px\"><\/td><td style=\"border-width:0;width:80px;padding-right:0;padding-left:0\"><\/td><td style=\"border-width:0;width:80px\"><\/td><td colspan=\"2\" style=\"border-width:0;width:220px;text-align:center;padding-right:0;padding-left:0\"><img decoding=\"async\" class=\"wp-image-657\" style=\"width: 298px;\" src=\"https:\/\/vip-msd.com\/jda-v1-12\/wp-content\/uploads\/sites\/215\/2025\/08\/winrevair-table-range-bottom.png\" alt=\"\"><\/td><td style=\"border-width:0;width:220px;text-align:center\"><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:24px;--tablet-spacer:0px;--mobile-spacer:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n<link rel='stylesheet' id='vivid360-card-css-css' href='https:\/\/www.merckconnect.com\/winrevair\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/card\/css\/style.min.css?ver=1773241827' media='all' \/>\n\n<div id=\"\" class=\"wp-block-vivid360-card aecfebdf1-0ed0-4c5d-9c31-efd48893f8bb vivid360-block-card has-text-align-left card-horizontal has-secondary-2-border-color has-error-light-bgr-background-color content-width\" style=\"border-width:0px;border-style:;border-radius:0;color:#111 !important\"><div class=\"card-media\"><figure class=\"ratio-1-1 ratio-1-1-mobile\"><picture><source media=\"(max-width: 767px)\" data-srcset=\"https:\/\/www.merckconnect.com\/winrevair\/wp-content\/uploads\/sites\/112\/2025\/07\/890_8.png?w=767\"\/><source media=\"(min-width: 768px) and (max-width: 1440px)\" data-srcset=\"https:\/\/www.merckconnect.com\/winrevair\/wp-content\/uploads\/sites\/112\/2025\/07\/890_updated.png?w=1440\"\/><img decoding=\"async\" data-src=\"https:\/\/www.merckconnect.com\/winrevair\/wp-content\/uploads\/sites\/112\/2025\/07\/890_updated.png\" src=\"https:\/\/www.merckconnect.com\/winrevair\/wp-content\/uploads\/sites\/112\/2025\/07\/890_updated.png\" alt=\"\"\/><\/picture><\/figure><\/div><div class=\"card-content\"><div class=\"card-content-wrap\"><div class=\"card-desc has-regular-font-size\">\n\n<div class=\"paragraph-wrapper\"><div class=\"_c91e6bbb-6a53-4b8d-bbe7-b56496ef20db \" id=\"\"><p class=\"has-medium-font-size\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-secondary-2-color\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-secondary-2-color\">Positive improvement trends were observed in prespecified subgroups, including double and triple therapy, and WHO FC II and III\u2028<\/mark><\/strong><\/mark><\/strong><\/p><\/div><\/div>\n\n\n<div class=\"paragraph-wrapper\"><div class=\"_5d8eb405-7e5f-4caa-815d-24049dcd27df \" id=\"\"><p class=\"has-medium-font-size\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-secondary-2-color\">These subgroup data were consistent with the primary endpoint<\/mark><\/strong><\/p><\/div><\/div>\n\n<\/div><\/div><\/div><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:24px;--mobile-spacer:8px;--tablet-spacer:24px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-mobile vivid360-spacer-tablet\"><\/div>\n\n\n\n<p class=\"has-small-font-size\"><sup>\u1d43<\/sup>Hodges-Lehmann location shift from placebo estimate (median of all paired differences).\u2028<\/p>\n\n\n\n<p class=\"has-small-font-size\"><sup>\u1d47<\/sup>Change from baseline in 6MWD at week 24 for subjects who died was imputed to -2000 meters to receive the worst rank. Change from baseline in 6MWD at week 24 for subjects who had missing data due to a non-fatal clinical worsening event was imputed to -1,000 meters to receive the next-worst rank.\u2028<\/p>\n\n\n\n<p class=\"has-small-font-size\">CHD = congenital heart disease; CI = confidence interval; CTD = connective tissue diseases; PVR = pulmonary vascular resistance; s\/p = systemic-to-pulmonary.<\/p>\n\n\n\n<div style=\"background-color:transparent;height:32px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-32\"><\/div>\n\n\n\n<p class=\"has-dark-text-color has-text-color has-link-color has-small-font-size wp-elements-7ed6f4c2035ab3208b83fb6954bd43fa\"><div class=\"paragraph-wrapper\"><div class=\"_2df920ae-82ee-48d4-9f04-a24398ddf29a \" id=\"\"><p class=\"has-dark-text-color has-text-color has-link-color has-small-font-size\"><strong>Reference:<\/strong><br><strong>1.<\/strong> Hoeper MM, Badesch DB, Ghofrani HA, et al; STELLAR Trial Investigators. Phase 3 trial of sotatercept for treatment of pulmonary arterial hypertension. <em>N Engl J Med.<\/em> 2023;388(16):1478-1490.<\/p><\/div><\/div><\/p>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:32px;--mobile-spacer:16px;--tablet-spacer:32px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-mobile vivid360-spacer-tablet\"><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:2px;--tablet-spacer:8px;--mobile-spacer:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<div class=\"wp-block-columns mb-0 is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"vivid360-heading\" id=\"afac24d43-3abd-43a6-ae3f-486a89356643\"><h6 class=\"has-primary-color has-text-align-left has-error-light-bgr-background-color content-width fontWeightRegular padding-top-bottom10 mt-0 mb-0 padding-left-right15\" style=\"--desktopFontSize:16;--tabletFontSize:16;--mobileFontSize:16;--desktopLineHeightSize:24px;--tabletLineHeightSize:24px;--mobileLineHeightSize:;--tabletAlign:left;--mobileAlign:left\" id=\"\"><strong>Report exposure during pregnancy or lactation to the <span class=\"no-wrap-text\">Merck Sharp &amp; Dohme<\/span> LLC Adverse Event reporting line at <span class=\"no-wrap-text\">1-877-888-4231<\/span><\/strong><\/h6><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:70px\"><\/div>\n<\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:32px;--tablet-spacer:0px;--mobile-spacer:0px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Actor Portrayal Patients taking WINREVAIR walked 41 meters more\u1d43 (95% CI: 28: 54; P&lt;0.001) in 6 minutes at 24 weeks than patients&#8230;<\/p>\n","protected":false},"author":4249,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_trash_the_other_posts":false,"editor_notices":[],"footnotes":""},"ga4_page_audience":[],"ga4_page_birn_id":[],"ga4_page_branding":[],"ga4_page_businessunit":[],"ga4_page_campaign":[],"ga4_page_content_purpose":[],"ga4_page_customer_journey_stage":[],"ga4_page_customer_specialty":[],"ga4_page_experience":[],"ga4_page_indication":[],"ga4_page_material_intent":[],"ga4_page_product":[],"ga4_page_region":[],"ga4_page_therapeuticarea":[],"user_role":[],"mhh-area-of-interest":[],"access":[],"user_status":[],"class_list":["post-7355","page","type-page","status-publish"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Primary Endpoint Data From a Phase III Clinical Trial for WINREVAIR\u2122 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