{"id":1899,"date":"2024-05-02T13:17:59","date_gmt":"2024-05-02T13:17:59","guid":{"rendered":"https:\/\/www.merckconnect.com\/zerbaxa\/?page_id=1899"},"modified":"2026-03-24T09:25:24","modified_gmt":"2026-03-24T09:25:24","slug":"preparation-storage-handling","status":"publish","type":"page","link":"https:\/\/www.merckconnect.com\/zerbaxa\/preparation-storage-handling\/","title":{"rendered":"Preparation, storage &amp; handling for ZERBAXA"},"content":{"rendered":"<link rel='stylesheet' id='vivid360-heading-css-css' href='https:\/\/www.merckconnect.com\/zerbaxa\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/heading\/css\/style.min.css?ver=1766071753' media='all' \/>\n\n<div class=\"vivid360-heading default-hcp-tablet-fontsize\" id=\"a940f12a6-6307-47ee-93e9-eb9071d18d06\"><h1 class=\"content-width fontWeightRegular\" style=\"--desktopFontSize:36px;--tabletFontSize:var(--h1FontSizeDesktop);--mobileFontSize:24px;--desktopLineHeightSize:45px;--tabletLineHeightSize:var(--h1LineHeightDesktop);--mobileLineHeightSize:\" id=\"\"><strong>Preparation, storage, &amp; handling for ZERBAXA\u00ae (ceftolozane and tazobactam)<br><\/strong><\/h1><\/div>\n\n\n<link rel='stylesheet' id='vivid360-spacer-css-css' href='https:\/\/www.merckconnect.com\/zerbaxa\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/spacer\/css\/style.min.css?ver=1766071753' media='all' \/>\n\n<div style=\"background-color:transparent;--desktop-spacer:24px;--tablet-spacer:24px;--mobile-spacer:24px;height:24px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<div class=\"vivid360-heading default-hcp-fontsize default-hcp-tablet-fontsize default-hcp-mobile-fontsize\" id=\"a6cbc2348-f9eb-4918-9331-a2cd5667548c\"><h2 class=\"content-width fontWeightRegular\" style=\"--desktopFontSize:var(--h2FontSizeDesktop);--tabletFontSize:var(--h2FontSizeDesktop);--mobileFontSize:var(--h2FontSizeMobile);--desktopLineHeightSize:var(--h2LineHeightDesktop);--tabletLineHeightSize:var(--h2LineHeightDesktop);--mobileLineHeightSize:\" id=\"\"><strong>Preparation of solutions<\/strong><\/h2><\/div>\n\n\n\n<div style=\"background-color:transparent;height:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-8\"><\/div>\n\n\n\n<p>ZERBAXA does not contain a bacteriostatic preservative. Aseptic technique must be followed in preparing the infusion solution.&nbsp;<\/p>\n\n\n\n<div style=\"background-color:transparent;height:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-8\"><\/div>\n\n\n\n<div class=\"vivid360-heading default-hcp-fontsize default-hcp-tablet-fontsize default-hcp-mobile-fontsize\" id=\"a198c87f9-0230-4f46-9a6c-db818be59081\"><h2 class=\"content-width fontWeightRegular\" style=\"--desktopFontSize:var(--h2FontSizeDesktop);--tabletFontSize:var(--h2FontSizeDesktop);--mobileFontSize:var(--h2FontSizeMobile);--desktopLineHeightSize:var(--h2LineHeightDesktop);--tabletLineHeightSize:var(--h2LineHeightDesktop);--mobileLineHeightSize:\" id=\"\"><strong>Preparation of doses<\/strong><\/h2><\/div>\n\n\n\n<div style=\"background-color:transparent;height:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-8\"><\/div>\n\n\n\n<p>Constitute each vial of ZERBAXA with <span class=\"no-wrap-text\">10 mL<\/span> of sterile water for injection or 0.9% Sodium Chloride for Injection, USP and gently shake to dissolve. The final volume is approximately <span class=\"no-wrap-text\">11.4 mL<\/span> per vial.<\/p>\n\n\n\n<div style=\"background-color:transparent;height:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-8\"><\/div>\n\n\n\n<p><strong>Caution: The constituted solution is not for direct injection.<\/strong><\/p>\n\n\n\n<div style=\"background-color:transparent;height:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-8\"><\/div>\n\n\n\n<p>To prepare the required dose, withdraw the appropriate volume as shown below from the reconstituted vial(s). Add the withdrawn volume to an infusion bag containing 100 mL of 0.9% Sodium Chloride for Injection, USP or 5% Dextrose Injection, USP. For doses above 1.5 g, reconstitute a second vial in the same manner as the first one, withdraw an appropriate volume as shown below, and add to the same infusion bag. Discard unused portion.<\/p>\n\n\n\n<div style=\"background-color:transparent;height:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-8\"><\/div>\n\n\n\n<div class=\"wp-block-columns mb-0 is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:70%\">\n<figure class=\"wp-block-flexible-table-block-table mb-0\"><table class=\"has-fixed-layout\"><tbody><tr><td style=\"background-color:#bf5411;color:#FFF;width:40%;border-color:#435363 #fff #FFF #435363;border-width:1px 1px 0\"><strong>ZERBAXA (ceftolozane and tazobactam) dose<\/strong><\/td><td style=\"background-color:#bf5411;color:#FFF;width:60%;border-color:#435363 #435363 #FFF;border-width:1px 1px 0\"><strong>Volume to withdraw from reconstituted vial(s)<\/strong><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n<link rel='stylesheet' id='vivid360-table-css-css' href='https:\/\/www.merckconnect.com\/zerbaxa\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/table\/css\/style.min.css?ver=6.8.5' media='all' \/>\n<link rel='stylesheet' id='vivid360-table-sortable-css-css' href='https:\/\/www.merckconnect.com\/zerbaxa\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/table\/css\/sortable.min.css?ver=6.8.5' media='all' \/>\n\n<figure class=\"wp-block-vivid360-table content-width mt-0\"><table id=\"ac98e95be-f34a-45a1-8905-636f8eea1937-vivid360-table-id\" class=\"ac98e95be-f34a-45a1-8905-636f8eea1937 squished\" style=\"--tableBorder:1px solid #435363;--tableBorderRadius:0\" role=\"grid\"><tbody><tr style=\"background-color:#fff\"><td class=\"has-black-color has-regular-font-size\" style=\"color:undefined!important\" width=\"40%\">3 g (<span class=\"no-wrap-text\">2 g<\/span>&nbsp;and&nbsp;<span class=\"no-wrap-text\">1 g<\/span>)<\/td><td class=\"has-black-color has-regular-font-size\" style=\"color:undefined!important\" width=\"60%\">Two vials of <span class=\"no-wrap-text\">11.4 mL<\/span> each (entire contents from two vials)<br><\/td><\/tr><tr style=\"background-color:#FFF\"><td class=\"has-black-color has-regular-font-size\" style=\"color:undefined!important\" width=\"40%\">2.25 g (<span class=\"no-wrap-text\">1.5 g<\/span>&nbsp;and&nbsp;<span class=\"no-wrap-text\">0.75 g<\/span>)<\/td><td class=\"has-black-color has-regular-font-size\" style=\"color:undefined!important\" width=\"60%\">11.4 mL from one vial (entire contents) and&nbsp;<span class=\"no-wrap-text\">5.7 mL<\/span>&nbsp;from a second vial<\/td><\/tr><tr style=\"background-color:#fff\"><td class=\"has-black-color has-regular-font-size\" style=\"color:undefined!important\" width=\"40%\">1.5 g (<span class=\"no-wrap-text\">1 g<\/span> and&nbsp;<span class=\"no-wrap-text\">0.5 g<\/span>)<\/td><td class=\"has-black-color has-regular-font-size\" style=\"color:undefined!important\" width=\"60%\">11.4 mL (entire contents from one vial)<\/td><\/tr><tr style=\"background-color:#FFF\"><td class=\"has-black-color has-regular-font-size\" style=\"color:undefined!important\" width=\"40%\">750 mg (<span class=\"no-wrap-text\">500 mg<\/span>&nbsp;and&nbsp;<span class=\"no-wrap-text\">250 mg<\/span>)<\/td><td class=\"has-black-color has-regular-font-size\" style=\"color:undefined!important\" width=\"60%\">5.7 mL<\/td><\/tr><tr style=\"background-color:#fff\"><td class=\"has-black-color has-regular-font-size\" style=\"color:undefined!important\" width=\"40%\">450 mg (<span class=\"no-wrap-text\">300 mg<\/span>&nbsp;and&nbsp;<span class=\"no-wrap-text\">150 mg<\/span>)<\/td><td class=\"has-black-color has-regular-font-size\" style=\"color:undefined!important\" width=\"60%\">3.5 mL<\/td><\/tr><tr style=\"background-color:#FFF\"><td class=\"has-black-color has-regular-font-size\" style=\"color:undefined!important\" width=\"40%\">375 mg (<span class=\"no-wrap-text\">250 mg<\/span>&nbsp;and&nbsp;<span class=\"no-wrap-text\">125 mg<\/span>)<\/td><td class=\"has-black-color has-regular-font-size\" style=\"color:undefined!important\" width=\"60%\">2.9 mL<\/td><\/tr><tr style=\"background-color:#fff\"><td class=\"has-black-color has-regular-font-size\" style=\"color:undefined!important\" width=\"40%\">150 mg (<span class=\"no-wrap-text\">100 mg<\/span>&nbsp;and&nbsp;<span class=\"no-wrap-text\">50 mg<\/span>)<\/td><td class=\"has-black-color has-regular-font-size\" style=\"color:undefined!important\" width=\"60%\">1.2 mL<\/td><\/tr><\/tbody><\/table><div class=\"\"><small class=\"table-caption\"><\/small><\/div><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:30%\"><\/div>\n<\/div>\n\n\n\n<div style=\"background-color:transparent;height:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-8\"><\/div>\n\n\n\n<p>Inspect drug products visually for particulate matter and discoloration prior to use. ZERBAXA infusions range from clear, colorless solutions to solutions that are clear and slightly yellow. Variations in color within this range do not affect the potency of the product.<\/p>\n\n\n\n<div style=\"background-color:transparent;height:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-8\"><\/div>\n\n\n\n<div class=\"vivid360-heading\" id=\"a6ed3aff0-471e-4793-9389-cc6ab087b52a\"><h3 class=\"content-width fontWeightRegular\" style=\"--desktopFontSize:var(--h3FontSizeDesktop);--tabletFontSize:var(--h3FontSizeDesktop);--mobileFontSize:var(--h3FontSizeMobile);--desktopLineHeightSize:var(--h3LineHeightDesktop);--tabletLineHeightSize:var(--h3LineHeightDesktop);--mobileLineHeightSize:\" id=\"\"><strong>Compatibility<\/strong><\/h3><\/div>\n\n\n\n<div style=\"background-color:transparent;height:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-8\"><\/div>\n\n\n\n<p>Compatibility of ZERBAXA with other drugs has not been established. ZERBAXA should not be mixed with other drugs or physically added to solutions containing other drugs.<\/p>\n\n\n\n<div style=\"background-color:transparent;height:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-8\"><\/div>\n\n\n\n<div class=\"vivid360-heading\" id=\"ab87ee2ee-5ae1-453c-98a2-1caccd38d550\"><h3 class=\"content-width fontWeightRegular\" style=\"--desktopFontSize:var(--h3FontSizeDesktop);--tabletFontSize:var(--h3FontSizeDesktop);--mobileFontSize:var(--h3FontSizeMobile);--desktopLineHeightSize:var(--h3LineHeightDesktop);--tabletLineHeightSize:var(--h3LineHeightDesktop);--mobileLineHeightSize:\" id=\"\"><strong>Storage of constituted solutions<\/strong><\/h3><\/div>\n\n\n\n<div style=\"background-color:transparent;height:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-8\"><\/div>\n\n\n\n<p>Upon constitution with sterile water for injection or 0.9% sodium chloride injection, reconstituted ZERBAXA solution may be held for 1 hour prior to transfer and dilution in a suitable infusion bag.<\/p>\n\n\n\n<div style=\"background-color:transparent;height:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-8\"><\/div>\n\n\n\n<p>Following dilution of the solution with 0.9% sodium chloride or 5% dextrose, ZERBAXA is stable for 24 hours when stored at room temperature or 7 days when stored under refrigeration at 2 to 8\u00b0C (36 to 46\u00b0F). Discard unused portion.<\/p>\n\n\n\n<div style=\"background-color:transparent;height:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-8\"><\/div>\n\n\n\n<p>Constituted ZERBAXA solution or diluted ZERBAXA infusion should not be frozen.<\/p>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:24px;--tablet-spacer:24px;--mobile-spacer:24px;height:24px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>ZERBAXA does not contain a bacteriostatic preservative. Aseptic technique must be followed in preparing the infusion solution.&nbsp; Constitute each vial of ZERBAXA&#8230;<\/p>\n","protected":false},"author":389,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_trash_the_other_posts":false,"editor_notices":[],"footnotes":""},"ga4_page_audience":[],"ga4_page_birn_id":[],"ga4_page_branding":[267],"ga4_page_businessunit":[],"ga4_page_campaign":[],"ga4_page_content_purpose":[319],"ga4_page_customer_journey_stage":[333],"ga4_page_customer_specialty":[358],"ga4_page_experience":[],"ga4_page_indication":[],"ga4_page_material_intent":[522],"ga4_page_product":[706],"ga4_page_region":[749],"ga4_page_therapeuticarea":[],"user_role":[],"mhh-area-of-interest":[],"access":[],"user_status":[],"class_list":["post-1899","page","type-page","status-publish"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Storage and Handling Information for ZERBAXA\u00ae (ceftolozane and tazobactam)<\/title>\n<meta name=\"description\" content=\"Read about storage, preparation, and handling requirements for ZERBAXA\u00ae (ceftolozane and tazobactam) before administering to patients.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.merckconnect.com\/zerbaxa\/preparation-storage-handling\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Storage and Handling Information for ZERBAXA\u00ae (ceftolozane and tazobactam)\" \/>\n<meta property=\"og:description\" content=\"Read about storage, preparation, and handling requirements for ZERBAXA\u00ae (ceftolozane and tazobactam) before administering to patients.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.merckconnect.com\/zerbaxa\/preparation-storage-handling\/\" \/>\n<meta property=\"og:site_name\" content=\"zerbaxa\" \/>\n<meta property=\"article:modified_time\" content=\"2026-03-24T09:25:24+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Storage and Handling Information for ZERBAXA\u00ae (ceftolozane and tazobactam)","description":"Read about storage, preparation, and handling requirements for ZERBAXA\u00ae (ceftolozane and tazobactam) before administering to patients.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.merckconnect.com\/zerbaxa\/preparation-storage-handling\/","og_locale":"en_US","og_type":"article","og_title":"Storage and Handling Information for ZERBAXA\u00ae (ceftolozane and tazobactam)","og_description":"Read about storage, preparation, and handling requirements for ZERBAXA\u00ae (ceftolozane and tazobactam) before administering to patients.","og_url":"https:\/\/www.merckconnect.com\/zerbaxa\/preparation-storage-handling\/","og_site_name":"zerbaxa","article_modified_time":"2026-03-24T09:25:24+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.merckconnect.com\/zerbaxa\/preparation-storage-handling\/","url":"https:\/\/www.merckconnect.com\/zerbaxa\/preparation-storage-handling\/","name":"Storage and Handling Information for ZERBAXA\u00ae (ceftolozane and tazobactam)","isPartOf":{"@id":"https:\/\/www.merckconnect.com\/zerbaxa\/#website"},"datePublished":"2024-05-02T13:17:59+00:00","dateModified":"2026-03-24T09:25:24+00:00","description":"Read about storage, preparation, and handling requirements for ZERBAXA\u00ae (ceftolozane and tazobactam) before administering to patients.","breadcrumb":{"@id":"https:\/\/www.merckconnect.com\/zerbaxa\/preparation-storage-handling\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.merckconnect.com\/zerbaxa\/preparation-storage-handling\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.merckconnect.com\/zerbaxa\/preparation-storage-handling\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.merckconnect.com\/zerbaxa\/"},{"@type":"ListItem","position":2,"name":"Preparation, storage &amp; 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