{"id":2356,"date":"2025-10-06T10:43:52","date_gmt":"2025-10-06T10:43:52","guid":{"rendered":"https:\/\/www.merckconnect.com\/zerbaxa\/?page_id=2356"},"modified":"2026-04-09T12:22:22","modified_gmt":"2026-04-09T12:22:22","slug":"idsa-guidance","status":"publish","type":"page","link":"https:\/\/www.merckconnect.com\/zerbaxa\/idsa-guidance\/","title":{"rendered":"select IDSA guidance"},"content":{"rendered":"<link rel='stylesheet' id='vivid360-paragraph-css-css' href='https:\/\/www.merckconnect.com\/zerbaxa\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/custom-paragraph\/css\/style.min.css?ver=1765966675' media='all' \/>\n<p  class=\"vivid360-paragraph\" style=\"--desktopfontsize:16px;--desktoplineheight:24px;--tabletfontsize:16px;--tabletlineheight:24px;--mobilefontsize:16px;--mobilelineheight:24px;\" dir=\"ltr\">\n\n<\/p>\n\n<link rel='stylesheet' id='vivid360-spacer-css-css' href='https:\/\/www.merckconnect.com\/zerbaxa\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/spacer\/css\/style.min.css?ver=1765194012' media='all' \/>\n\n<div style=\"background-color:transparent;--desktop-spacer:24px;--mobile-spacer:24px;--tablet-spacer:24px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-mobile vivid360-spacer-tablet\"><\/div>\n\n\n<link rel='stylesheet' id='vivid360-heading-css-css' href='https:\/\/www.merckconnect.com\/zerbaxa\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/heading\/css\/style.min.css?ver=1765194012' media='all' \/>\n\n<div class=\"vivid360-heading default-hcp-tablet-fontsize\" id=\"ae42f17e4-a410-447e-bb06-af637a8359ba\"><h1 class=\"content-width fontWeightRegular\" style=\"color:#333333;--desktopFontSize:30px;--tabletFontSize:var(--h1FontSizeDesktop);--mobileFontSize:24px;--desktopLineHeightSize:45px;--tabletLineHeightSize:var(--h1LineHeightDesktop);--mobileLineHeightSize:\" id=\"\"><strong>2024 IDSA Guidance* includes:<\/strong><\/h1><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:2px;--mobile-spacer:8px;--tablet-spacer:2px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-mobile vivid360-spacer-tablet\"><\/div>\n\n\n<link rel='stylesheet' id='vivid360-list-parent-css-css' href='https:\/\/www.merckconnect.com\/zerbaxa\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/list-parent\/css\/style.css?ver=1765194012' media='all' \/>\n\n<div class=\"vivid-block-list2 content-width  \">\n<ul style=\"--listBulletColor:#333\" class=\"list-bullet-color has-medium-font-size\">\n<li class=\"has-medium-font-size\"><strong><span class=\"word-break\"><mark style=\"background-color:rgba(0, 0, 0, 0);color:#333333\" class=\"has-inline-color\">Ceftolozane-tazobactam for the treatment of certain infections caused by MDR <em>P. aeruginosa<\/em> in critically ill patients or patients with poor source control<sup>1,a<\/sup><\/mark><\/span><\/strong><\/li>\n\n\n\n<li class=\"has-medium-font-size\"><strong><span class=\"word-break\"><mark style=\"background-color:rgba(0, 0, 0, 0);color:#333333\" class=\"has-inline-color\">Ceftolozane-tazobactam for treatment of select polymicrobial infections such as those caused by both ESBL-E and <em><span class=\"no-wrap-text\">P. aeruginosa<\/span><\/em> with certain mechanisms of resistance.<sup>1,a<\/sup><\/mark><\/span><\/strong><\/li>\n<\/ul>\n<\/div>\n\n\n\n<div style=\"background-color:transparent;height:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-8\"><\/div>\n\n\n\n<div class=\"paragraph-wrapper wp-elements-b53d98809046974f8fecc5d834e93928\"><div class=\"_cfbf1762-27ab-467a-bbad-f86388fc3cc2 \" id=\"\"><p class=\"has-text-color has-link-color\" style=\"color:#333333;font-size:14px\">*2024 Infectious Diseases Society of America (IDSA) Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections.<sup>1<\/sup><\/p><\/div><\/div>\n\n\n\n<div class=\"paragraph-wrapper wp-elements-d396d14f5c17e0d7e9cb4b44fbdcdc3e\"><div class=\"_4a82d9fa-2277-4d57-9908-f32d84527699 \" id=\"\"><p class=\"has-text-color has-link-color\" style=\"color:#333333;font-size:14px\"><sup>a<\/sup>Dosing suggestions in IDSA guidance for several agents may differ from dosing in approved labels.<\/p><\/div><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:24px;--mobile-spacer:32px;--tablet-spacer:24px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-mobile vivid360-spacer-tablet\"><\/div>\n\n\n\n<div class=\"vivid360-heading default-hcp-tablet-fontsize\" id=\"a5bce5e43-e6b7-42df-be18-8d06a9eaea8f\"><h2 class=\"has-primary-color content-width fontWeightRegular\" style=\"--desktopFontSize:24px;--tabletFontSize:var(--h2FontSizeDesktop);--mobileFontSize:20px;--desktopLineHeightSize:36px;--tabletLineHeightSize:var(--h2LineHeightDesktop);--mobileLineHeightSize:\" id=\"\"><strong>Dosing and administration<\/strong><\/h2><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:0px;--mobile-spacer:8px;--tablet-spacer:0px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-mobile vivid360-spacer-tablet\"><\/div>\n\n\n\n<div class=\"vivid360-heading\" id=\"a95279307-c83e-4f2a-b2b4-9a3f93caa4fb\"><h3 class=\"content-width fontWeightBold\" style=\"color:#333333;--desktopFontSize:20px;--tabletFontSize:var(--h3FontSizeDesktop);--mobileFontSize:18px;--desktopLineHeightSize:30px;--tabletLineHeightSize:var(--h3LineHeightDesktop);--mobileLineHeightSize:\" id=\"\"><strong>Approved dosage for adults patients with hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia <strong>(HABP\/VABP)<sup>b,c<\/sup><\/strong><\/strong><\/h3><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:0px;--mobile-spacer:8px;--tablet-spacer:0px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-mobile vivid360-spacer-tablet\"><\/div>\n\n\n\n<p class=\"has-text-color has-link-color wp-elements-b4afb6b8735d41d0460621d7cb7b9a85\" style=\"color:#000000\">The recommended dose of ZERBAXA in adult patients 18 years and older with HABP\/VABP and creatinine clearance (CrCI) greater than <span class=\"no-wrap-text\">50 mL\/min<\/span> is <span class=\"no-wrap-text\">3 grams (two 1.5 g vials)<\/span> over <span class=\"no-wrap-text\">1-hour<\/span> period every <span class=\"no-wrap-text\">8 hours<\/span> for 8 to 14 days. The duration of therapy should be guided by the severity and site of infection and the patient&#8217;s clinical and bacteriological progress.<\/p>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:16px;--mobile-spacer:24px;--tablet-spacer:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-mobile vivid360-spacer-tablet\"><\/div>\n\n\n\n<div class=\"vivid360-heading\" id=\"afc772235-827b-4e71-888a-c8b41ab99bd5\"><h3 class=\"content-width fontWeightRegular\" style=\"--desktopFontSize:var(--h3FontSizeDesktop);--tabletFontSize:var(--h3FontSizeDesktop);--mobileFontSize:var(--h3FontSizeMobile);--desktopLineHeightSize:var(--h3LineHeightDesktop);--tabletLineHeightSize:var(--h3LineHeightDesktop);--mobileLineHeightSize:\" id=\"\"><strong>Renal dosing adjustments for adult patients with HABP\/VABP per estimated CrCI (mL\/min)<sup>b,c<\/sup><\/strong><\/h3><\/div>\n\n\n\n<div class=\"vivid-block-list2 content-width  \">\n<ul style=\"color:#000000;--listBulletColor:#333\" class=\"list-bullet-color has-dark-text-color has-text-color has-link-color wp-elements-b53a0096b4ca1dcc3b13ffeb20ebac8b\">\n<li><strong>30 to 50 CrCI (mL\/min)<\/strong> <span class=\"no-wrap-text\">1.5 g (1 g and 0.5 g)<\/span> intravenously every 8 hours<\/li>\n\n\n\n<li><strong>15 to 29 CrCI (mL\/min)<\/strong> <span class=\"no-wrap-text\">750 mg<\/span> <span class=\"no-wrap-text\">(500 mg and 250 mg)<\/span> intravenously every <span class=\"no-wrap-text\">8 hours<\/span><\/li>\n\n\n\n<li>For patients with end-stage renal disease on hemodialysis: a single loading dose of 2.25 g <span class=\"no-wrap-text\">(1.5 g and 0.75 g)<\/span> followed by a 450-mg <span class=\"no-wrap-text\">(300 mg and 150 mg)<\/span> maintenance dose administered intravenously every 8 hours for the remainder of the treatment period (on hemodialysis days, administer the dose at the earliest possible time following completion of dialysis).<\/li>\n\n\n\n<li>The duration of therapy should be guided by the severity and site of infection and the patient&#8217;s clinical and bacteriological progress.<\/li>\n\n\n\n<li>For patients with changing renal function, monitor CrCl at least daily and adjust dosage of ZERBAXA accordingly.<\/li>\n<\/ul>\n<\/div>\n\n\n\n<div class=\"paragraph-wrapper wp-elements-8f1e1092a3113f4c76763702b6601483\"><div class=\"_49d0276c-17de-43d6-bade-735a108f690a \" id=\"\"><p class=\"has-text-color has-link-color\" style=\"color:#000000;font-size:14px\"><sup>b<\/sup>Creatinine clearance (CrCI) estimated using Cockcroft-Gault formula. <\/p><\/div><\/div>\n\n\n\n<div class=\"paragraph-wrapper wp-elements-a2ade0d844970c33fc918cbcad3eae1d\"><div class=\"_f845baf0-4481-43a3-88d4-5c8475300232 \" id=\"\"><p class=\"has-text-color has-link-color\" style=\"color:#000000;font-size:14px\"><sup>c<\/sup>All doses of ZERBAXA are administered over 1 hour.<\/p><\/div><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:24px;--mobile-spacer:24px;--tablet-spacer:24px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-mobile vivid360-spacer-tablet\"><\/div>\n\n\n<link rel='stylesheet' id='vivid360-card-css-css' href='https:\/\/www.merckconnect.com\/zerbaxa\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/card\/css\/style.min.css?ver=1777396162' media='all' \/>\n\n<div id=\"\" class=\"wp-block-vivid360-card a495da969-6126-47a9-bcf9-9c794bb4913a vivid360-block-card has-text-align-left hasBoxShadow card-basic full-page-width\" style=\"border-width:0px;border-style:;border-radius:0;color:#111 !important;border-color:#333333\"><div class=\"card-content\"><div class=\"card-content-wrap\"><h3 class=\"card-header fontWeightBold\"><mark style=\"background-color:rgba(0, 0, 0, 0);color:#333333\" class=\"has-inline-color\">For information on dosing and administration for cIAI and cUTI:<\/mark><\/h3><div class=\"card-desc has-regular-font-size\">\n<p class=\"has-primary-color has-text-color has-link-color wp-elements-bc29eede74bb25ac0cc3fd0546be9adf\"><a aria-label=\"#\" href=\"https:\/\/www.merckconnect.com\/zerbaxa\/dosing-administration\/#Dosing-4\">Dosage for adult patients with cIAI and cUTI<\/a><\/p>\n<\/div><\/div><\/div><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:24px;--mobile-spacer:24px;--tablet-spacer:24px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-mobile vivid360-spacer-tablet\"><\/div>\n\n\n\n<div class=\"vivid360-heading default-hcp-fontsize default-hcp-tablet-fontsize default-hcp-mobile-fontsize\" id=\"aa6cde8a7-f0bc-4d4c-986c-1242cd8fc6ae\"><h2 class=\"content-width fontWeightRegular\" style=\"--desktopFontSize:var(--h2FontSizeDesktop);--tabletFontSize:var(--h2FontSizeDesktop);--mobileFontSize:var(--h2FontSizeMobile);--desktopLineHeightSize:var(--h2LineHeightDesktop);--tabletLineHeightSize:var(--h2LineHeightDesktop);--mobileLineHeightSize:\" id=\"\"><strong>Reference<\/strong><\/h2><\/div>\n\n\n\n<div class=\"vivid-block-list2 content-width  \">\n<ol style=\"--listBulletColor:#333\" class=\"list-bullet-color has-small-font-size\">\n<li>Tamma PD, Heil EL, Justo JA, Mathers AJ, Satlin MJ, Bonomo RA. <em>Clin Infect Dis<\/em>. Published online August 7, 2024. doi:10.1093\/cid\/ciae403<\/li>\n<\/ol>\n<\/div>\n\n\n\n<div style=\"background-color:transparent;height:32px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-32\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>*2024 Infectious Diseases Society of America (IDSA) Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections.1 aDosing suggestions in IDSA guidance for several&#8230;<\/p>\n","protected":false},"author":5494,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_trash_the_other_posts":false,"editor_notices":[],"footnotes":""},"ga4_page_audience":[],"ga4_page_birn_id":[],"ga4_page_branding":[],"ga4_page_businessunit":[],"ga4_page_campaign":[],"ga4_page_content_purpose":[],"ga4_page_customer_journey_stage":[],"ga4_page_customer_specialty":[],"ga4_page_experience":[],"ga4_page_indication":[],"ga4_page_material_intent":[],"ga4_page_product":[],"ga4_page_region":[],"ga4_page_therapeuticarea":[],"user_role":[],"mhh-area-of-interest":[],"access":[],"user_status":[],"class_list":["post-2356","page","type-page","status-publish"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>IDSA Guidance for ZERBAXA\u00ae (ceftolozane and tazobactam)<\/title>\n<meta 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