Dosing for DIFICID® (fidaxomicin)
Twice-daily oral dosing
Tablets
- Adult and pediatric patients weighing at least 12.5 kg and able to swallow tablets take 200 mg of DIFICID.
- The recommended dose of DIFICID is one 200-mg tablet orally twice daily for 10 days, with or without food.
- No dose adjustment is recommended for patients ≥65 years of age.
- No dose adjustment is recommended for patients with renal impairment.
- No dosage adjustments are recommended when co-administering fidaxomicin with substrates of P-gp or CYP enzymes.
- The impact of hepatic impairment on the pharmacokinetics of fidaxomicin has not been evaluated; however, because fidaxomicin and its active metabolite (OP-1118) do not appear to undergo significant hepatic metabolism, elimination of fidaxomicin and OP-1118 is not expected to be significantly affected by hepatic impairment.