Dosing for PREVYMIS® (letermovir) in CMV R+ allogeneic HSCT patients
Once-daily dosing with PREVYMIS as early as the day of transplant
- Start PREVYMIS as early as day 0 and no later than day 28 post-transplant.
- PREVYMIS can be initiated before or after engraftment.
- Following the completion of prophylaxis with PREVYMIS, monitoring for CMV reactivation in HSCT recipients is recommended.
Oral or IV dosing
The recommended dosage of PREVYMIS is 480 mg administered orally or intravenously once daily.
- If coadministered with cyclosporine, the recommended dose of PREVYMIS is 240 mg once daily.
- Please see full Prescribing Information for proper preparation and administration of PREVYMIS IV infusion.
Once-daily dosing
Dosage forms
![The Recommended Dosage of PREVYMIS® is 480 mg Administered Orally or Intravenously Once Daily](https://www.merckconnect.com/prevymis/wp-content/uploads/sites/88/2024/03/prevymis-dosing-tablet-480-1.png)
480 mg tablet
![PREVYMIS® (letermovir) 480 mg IV Infusion Vial](https://www.merckconnect.com/prevymis/wp-content/uploads/sites/88/2024/03/prevymis-dosing-vial-480-1-1.png)
480 mg/24 mL vial
![If Co-administered With Cyclosporine, the Recommended Dose of PREVYMIS is 240 mg Once Daily](https://www.merckconnect.com/prevymis/wp-content/uploads/sites/88/2024/03/prevymis-dosing-tablet-240-1.png)
240 mg tablet
![PREVYMIS® (letermovir) 240 mg IV Infusion Vial](https://www.merckconnect.com/prevymis/wp-content/uploads/sites/88/2024/03/prevymis-dosing-vial-240_mob-2.png)
240 mg/12 mL vial
Tablets and vials not actual size.