Dosing for PREVYMIS® (letermovir) in kidney transplant patients
For prophylaxis against CMV disease in appropriate adult D+/R- kidney transplant recipients, start PREVYMIS as early as Day 0
Start PREVYMIS early (between Day 0 and Day 7 post-kidney transplant) and continue PREVYMIS through Day 200 post-transplant
- The recommended dosage of PREVYMIS is 480 mg administered orally or intravenously once daily
- If co-administered with cyclosporine, the recommended dose of PREVYMIS is 240 mg once daily
PREVYMIS has once-daily dosing:
No dosage adjustment is required in patients with renal impairment (CLcr > 10 mL/min)
- In patients with CLcr <50 mL/min receiving PREVYMIS injection, accumulation of the intravenous vehicle, hydroxypropyl betadex, may occur. Closely monitor serum creatinine levels in these patients
Administer orally or via IV
- May be used interchangeably at the discretion of the physician
- No dosage adjustment is needed when switching formulations
Can be taken with or without food
Oral or IV dosing
Once-daily dosing
Dosage forms
480 mg tablet
480 mg/24 mL vial
240 mg tablet
240 mg/12 mL vial
Tablets and vials not actual size.
- Please see full Prescribing Information for proper preparation and administration of PREVYMIS IV infusion.