Dosing
Dosing and administration
Dosage of RECARBRIO 1.25 g (imipenem 500 mg, cilastatin 500 mg, and relebactam 250 mg) for adult patients with creatinine clearance of 90 mL/min or greater
Infection | Dose (g) | Frequency | Infusion Time | Duration of Treatment |
---|---|---|---|---|
Hospital-acquired Bacterial Pneumonia and Ventilator-associated Bacterial Pneumonia (HABP/VABP) | 1.25 | Every 6 hours | 30 minutes | 4 to 14 days |
Complicated Urinary Tract Infections (cUTI), Including Pyelonephritis | 1.25 | Every 6 hours | 30 minutes | 4 to 14 days |
Complicated Intra-abdominal Infections (cIAI) | 1.25 | Every 6 hours | 30 minutes | 4 to 14 days |
The recommended duration of treatment is 4 days to 14 days. The severity and location of infection, as well as clinical response, should guide the duration of therapy.
Patients with renal impairment
Patients who have a creatinine clearance (CLcr) less than 90 mL/min require dosage reduction of RECARBRIO, as shown below. For patients with fluctuating renal function, CLcr should be monitored.
Dosage of RECARBRIO for adult patients with renal impairment
Estimated CLcr (mL/min)a | Recommended Dosage of RECARBRIO (imipenem, cilastatin, and relebactam) (mg)b | Dosing Interval |
---|---|---|
60 to 89 | 1 g (imipenem 400 mg, cilastatin 400 mg, and relebactam 200 mg) | Every 6 hours |
30 to 59 | 0.75 g (imipenem 300 mg, cilastatin 300 mg, and relebactam 150 mg) | Every 6 hours |
15 to 29 | 0.5 g (imipenem 200 mg, cilastatin 200 mg, and relebactam 100 mg) | Every 6 hours |
End-Stage Renal Disease (ESRD) on Hemodialysisc | 0.5 g (imipenem 200 mg, cilastatin 200 mg, and relebactam 100 mg) | Every 6 hours |
aCLcr calculated using the Cockcroft-Gault formula. bAdminister intravenously over 30 minutes. cAdministration should be timed to follow hemodialysis. RECARBRIO is provided as a single vial in a fixed-dose combination; the dose for each component will be adjusted equally during preparation. |
Patients with CLcr less than 15 mL/min should not receive RECARBRIO unless hemodialysis is instituted within 48 hours. There is inadequate information to recommend usage of RECARBRIO for patients undergoing peritoneal dialysis.
Download the Infusion and Billing Guide for RECARBRIO