Outpatient utilization of RECARBRIO™ (imipenem, cilastatin, and relebactam)
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Utilization of RECARBRIO in inpatient and outpatient treatment settings1
Infusion time is an important consideration when selecting an antimicrobial for outpatient use2
Dosing: RECARBRIO is infused over a 30-minute infusion time
Dosing regimen
Administer RECARBRIO 1.25 grams (imipenem 500 mg, cilastatin 500 mg, relebactam 250 mg) by intravenous (IV) infusion over 30 minutes every 6 hours in patients 18 years of age and older with creatinine clearance (CLcr) 90 mL/min or greater. Patients with CLcr less than 15 mL/min should not receive RECARBRIO unless hemodialysis is instituted within 48 hours.
Dosage of RECARBRIO for adult patients with renal impairment
RECARBRIO is provided as a single vial in a fixed-dose combination; the dose for each component will be adjusted equally during preparation.
Storage of constituted solution
RECARBRIO, as supplied in single-dose glass vials upon constitution with the appropriate diluent and following further dilution in the infusion bag, maintains satisfactory potency for at least 2 hours at room temperature (up to 30°C) or for at least 24 hours under refrigeration at 2°C to 8°C (36°F to 46°F). Do not freeze solutions of RECARBRIO.
cIAI, complicated intra-abdominal infection; CLcr, creatinine clearance; cUTI, complicated urinary tract infection; ESRD, end-stage renal disease; HABP, hospital-acquired bacterial pneumonia; VABP, ventilator-associated bacterial pneumonia.
References:
1. Data available on request from Merck Professional Services-DAP, WP1-27, PO Box 4, West Point, PA 19486-0004. Please specify information package US-TIX-00646.
2. Norris AH, Shrestha NK, Allison GM, et al. 2018 Infectious Diseases Society of America clinical practice guideline for the management of outpatient parenteral antimicrobial therapy. Clin Infect Dis. 2019;68(1):e1-e35. doi:10.1093/cid/ciy745
Outpatient leave-behind
Download the outpatient leave-behind for guidance on outpatient utilization and dosing information for RECARBRIO.