Dosing for ZERBAXA® (ceftolozane and tazobactam)
Learn about:
- Dosage for adult patients with HABP/VABP
- Phase 1 PK/PD study
- Dosage for adult patients with cIAI and cUTI
- Dosage for pediatric patients with cIAI and cUTI
- Dosing, administration, and billing guide
Dosing and administration
Dosage for adult patients with hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia (HABP/VABP)a,b
The recommended dose of ZERBAXA in adult patients 18 years and older with HABP/VABP and creatinine clearance (CrCl) greater than 50 mL/min is 3 grams (two 1.5 g vials) over 1-hour period every 8 hours for 8 to 14 days.


Renal dosing adjustments for adult patients with HABP/VABP per estimated CrCl (mL/min)a,b
- 30 to 50 1.5 g (1 g and 0.5 g) intravenously every 8 hours
- 15 to 29 750 mg (500 mg and 250 mg) intravenously every 8 hours
- For patients with end-stage renal disease on hemodialysis: a single loading dose of 2.25 g (1.5 g and 0.75 g) followed by a 450-mg (300 mg and 150 mg) maintenance dose administered intravenously every 8 hours for the remainder of the treatment period (on hemodialysis days, administer the dose at the earliest possible time following completion of dialysis).
aCreatinine clearance (CrCl) estimated using Cockcroft-Gault formula.
bAll doses of ZERBAXA are administered over 1 hour.